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| 1 | Mitophagy links oxidative stress conditions and neurodegenerative diseases显示文摘Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases. | Ulfuara Shefa Na Young Jeong In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung Youngbuhm Huh | 2019 | Neural Regeneration Research2019，14，5： | 21 |
| 2 | 中(西)澳地质填图对比及对中国地质填图的启示显示文摘为了解发达国家最新填图工作方法,吸取其精华并进一步完善国内填图方法、提高填图质量,中国地质调查局西安地质调查中心与西澳大利亚地调局开展了为期4年的地质填图技术方法交流合作。基于西澳大利亚州(以下简称西澳)伊尔岗克拉通和中国西部北山造山带3年的实地填图工作,系统地对比了中国与西澳地质填图的异同。双方在工作思路、工作程序等方面基本一致,但是在成果表达、数据集成、人员组织、质量管理等方面存在系统差异。对所有实体按照岩性进行划分和填图是西澳长期以来地质填图的基本思想,也是中国地质填图现在及将来努力的方向。系统逻辑的数据集成与共享也是值得借鉴的一个重要方面。地质调查、科研相结合与高素质人员进军地调队伍是提高填图质量的前提和基础,着眼于大区域的工作部署和稳定的区域地质调查队伍是加快填图速度的重要保障。 | 李建星 Chen Shefa 毛晓长 邱士东 孟勇 郭琳 | 2015 | 地质通报2015，34，12： | 8 |
| 3 | Comparative study of microarray and experimental data on Schwann cells in peripheral nerve degeneration and regeneration: big data analysis显示文摘A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses. According to microarray data, several genes exhibit increased expression(fold change) but they are weakly expressed in experimental studies(based on morphology, protein and mRNA levels). In contrast, some genes are weakly expressed in microarray data and highly expressed in experimental studies;such genes may represent future target genes in Schwann cell studies. These studies allow us to learn about additional genes that could be used to achieve targeted results from experimental studies. In the current big data study by retrieving more than 5000 scientific articles from PubMed or NCBI, Google Scholar, and Google, 1016(up-and downregulated) genes were determined to be related to Schwann cells. However,no experiment was performed in the laboratory; rather, the present study is part of a big data analysis. Our study will contribute to our understanding of Schwann cell biology by aiding in the identification of genes.Based on a comparative analysis of all microarray data, we conclude that the microarray could be a good tool for predicting the expression and intensity of different genes of interest in actual experiments. | Ulfuara Shefa Junyang Jung | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 4 | Active falting and movement associated with large earthquakes in the Min Shan and Longmen Mountains, northeastern Tibetan Plateau显示文摘 | Shefa Chen Wilson C J L | 1994 | Journal of Geophysical Research1994，99，24： | 1 |
| 5 | Active faulting and block movement associated with large earthquakes in the Minshan and Longmenshan mountains,northeastern Tibetan Plateau显示文摘 | Chen Shefa | | 0，，12： | 1 |
| 6 | Tectonic transition from the Songpan-Garze Fold Belt to the Sichuan Basin, South-Western China显示文摘 | Chen Shefa Wilson C J L Worley B A | 1995 | Basin Research1995，，7： | 1 |
| 7 | Emplacement of the Longmen Shan Thrust - Nappe Belt along the eastern margin of the Tibetan Plateau 显示文摘 | Chen Shefa Wilson C J L | 1996 | Journal of Structural Geology1996，18，4： | 1 |
| 8 | Emplacement of the Longmen Shan thrust-nappe belt along the eastern margin of the Tibetan Plateau显示文摘 | Chen Shefa Wilson C J L | 1996 | Journal of Structure Geology1996，18，4： | 1 |
| 9 | Structure and deformational character of strike-slip fault zones显示文摘 | Qidong Deng Daning Wu Peizhen Zhang Shefa Chen | 1986 | Pure and Applied Geophysics PAGEOPH (-)1986，，1： | 1 |
| 10 | Emplacement of the Longmenshan thrust-nappe belt along the eastern margin of the Tibetan Plateau显示文摘 | Chen Shefa Wilson C J L | 1996 | Journal of Structure Geology1996，18，4： | 1 |
| 11 | ENTROPY CHARACTERISTICS OF MAGNETIC REFRIGERANTS显示文摘Mathematical models for predicting magnetic entropy,lattice entropy and electron entropy of magnetic refrigerants are carried out from the molecular field appoximation,the Debye model and the electron energy level theory respectively of quantum mechanics.Using theabove models the temperature and magnetic field dependences of the calculated magnetic entropy,lattice entropy,electron entropy and the total entropy of gadolinium,which is a typical magnetic refrigerant near room temperature,are obtained.The Influences of kinds of entropy on the performance of magnetic refrigeration are discussed,and some general rules for selecting magnetic refrlyerants are drawn to hely the develoyment of highly economic magnetic refrigerators. | You Lixin Guo Xianming Xu Shefa (Denartment of Aircraft Engineering.NUAA,29 Yudao Street.Nanjing 210016.P.R.China) | 1994 | Transactions of Nanjing University of Aeronautics and Astronautics1994，11，2： | 0 |
| 12 | Trace Element Mobility in Subducted Marble and Associated Eclogite:Constraints from UHP Rocks in the Shuanghe Area,Central-East China显示文摘In order to decipher element mobility in UHP meta-sedimentary rocks in the continental subduction zone,major and trace element compositions are investigated for a continuous profile from a representative UHP region in the Dabie Mountains.Among the lithologic contact zone,contents of K,Ca,LREE,and LILE exhibit varying degrees of downward trends in both marble and eclogite toward the contact zone,indicating that marble and their associated eclogite can release a large amount of K,Ca,and a small number of LILEs and LREEs.Titanite is the main Ti phase in both marble and eclogite.Titanite rims around rutile can occasionally be seen in eclogite.Contents of Ti and HFSE exhibit a well-coupled relation among marble and eclogite,indicating that substantial Ti and HFSEs were migrated from eclogite to marble,in accord with the capacity of a melt medium.Rutiles and titanites in marble exhibit a relatively limited variation in Nb/Ta ratios(12.9-16.2),similar to those of titanites in eclogite(14.2-16.7),which demonstrates that rutiles and titanites in marble were sourced from eclogite because of short-distance migrations of Ti and HFSEs.According to the P-T path and the temperature and pressure conditions of the peak metamorphism reported by previous studies,the eclogite associated with marble may not form supercritical fluids in the subduction zone because of the addition of carbonate minerals. | Xingao Hou Zhiqiang Yu Shefa Chen Lei Liu Yilin Xiao | 2024 | Journal of Earth Science2024，35，1： | 0 |
| 13 | Big Data Bot with a Special Reference to Bioinformatics显示文摘There are quintillions of data on deoxyribonucleic acid(DNA)and protein in publicly accessible data banks,and that number is expanding at an exponential rate.Many scientific fields,such as bioinformatics and drug discovery,rely on such data;nevertheless,gathering and extracting data from these resources is a tough undertaking.This data should go through several processes,including mining,data processing,analysis,and classification.This study proposes software that extracts data from big data repositories automatically and with the particular ability to repeat data extraction phases as many times as needed without human intervention.This software simulates the extraction of data from web-based(point-and-click)resources or graphical user interfaces that cannot be accessed using command-line tools.The software was evaluated by creating a novel database of 34 parameters for 1360 physicochemical properties of antimicrobial peptides(AMP)sequences(46240 hits)from various MARVIN software panels,which can be later utilized to develop novel AMPs.Furthermore,for machine learning research,the program was validated by extracting 10,000 protein tertiary structures from the Protein Data Bank.As a result,data collection from the web will become faster and less expensive,with no need for manual data extraction.The software is critical as a first step to preparing large datasets for subsequent stages of analysis,such as those using machine and deep-learning applications. | Ahmad M.Al-Omari Shefa M.Tawalbeh Yazan H.Akkam Mohammad Al-Tawalbeh Shima’a Younis Abdullah A.Mustafa Jonathan Arnold | 2023 | Computers, Materials & Continua2023，，5： | 0 |
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