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| 1 | Unusual presentations of eosinophilic gastroenteritis:Case series and review of literature显示文摘Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy. | Rafiq A Sheikh Thomas P Prindiville R Erick Pecha Boris H Ruebner | 2009 | World Journal of Gastroenterology2009，15，17： | 43 |
| 2 | 合并糖代谢异常的冠心病患者血浆脂联素水平变化及其临床意义显示文摘目的:检测脂联素(adiponectin,ADPN)在合并糖代谢异常的冠心病患者血浆中浓度的变化,探讨其临床意义。方法:收集2009年8月至2010年4月在湘雅医院心内科经冠状动脉造影(coronary angiography,CAG)检查证实为冠心病的患者87名,根据糖代谢情况分为单纯冠心病组(coronary heart disease group,CHD组,n=31)、冠心病合并糖耐量异常组(CHD combine with impaired glucose tolerance group,CHD+IGT组,n=28)和冠心病合并糖尿病组(CHDcombine with diabetes mellitus group,CHD+DM组,n=28),另选健康体检者31例为正常对照组(normal control group,NC组)。采用酶联免疫吸附法检测血浆ADPN水平;为所有受试对象测身高、体质量、腰围、血压;测空腹血糖、胰岛素、血脂、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、游离脂肪酸(free fatty acid,FFA)和肝、肾功能等,计算体质量指数(body mass index,BMI)和胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-IR)。结果:1)CHD组、CHD+IGT组、CHD+DM组患者血浆ADPN水平均低于NC组(P<0.05);2)与CHD组相比,CHD+DM组ADPN水平最低,CHD+IGT组次之,各组间差异有统计学意义(P<0.05);3)ADPN与HDL-C呈正相关(r=0.483,P<0.01),与hs-CRP和冠脉Gensini积分呈负相关(r=–0.489,P<0.05;r=–0.252,P<0.05)。结论:冠心病患者血浆ADPN浓度降低;合并糖代谢异常的冠心病患者血浆ADPN浓度更低,且随着糖代谢异常程度加重降低更显著;冠心病与糖代谢异常是影响血浆ADPN浓度改变的两个重要因素,血浆ADPN水平显著降低反映了上述两种疾病状态的叠加作用。ADPN联合HDL-C,hs-CRP,Gensini积分等血清学指标可为判断合并糖代谢异常的冠心病患者的疾病严重程度提供一定参考。 | 夏珂 郭兰燕 赵震宇 Ali Sheikh Md Sayed 李非 杨天伦 | 2012 | 中南大学学报(医学版)2012，37，2： | 17 |
| 3 | 肝硬化和不可控制的静脉曲张出血患者死亡率的决定因素显示文摘【据Journal of Hepatology 2021年1月报道】肝硬化和不可控制的静脉曲张出血患者死亡率的决定因素(作者Kumar R等)不可控制的食管胃底静脉曲张出血(OGVB)和慢加急性肝衰竭(ACLF)均为肝硬化的重要预后因素。 | KUMAR R KERBERT AJC SHEIKH MF 王妍 金清龙 | 2021 | 临床肝胆病杂志2021，37，2： | 17 |
| 4 | Ampullary carcinoma:Effect of preoperative biliary drainage on surgical outcome显示文摘AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma. METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital. Diagnosis of ampullary carcinoma was confirmed histologically. Thirty-five patients underwent preoperative biliary drainage (PBD group), and 47 were not drained (non-PBD group). The mode of biliary drainage was endoscopic retrograde cholangiopancreatography (n = 33) or percutaneous biliary drainage (n = 2). The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate. Mortality was assessed at 30 d (hospital mortality) and also longterm. The statistical endpoint of this study was patient survival after surgery. RESULTS: The groups were well matched for demographic criteria, clinical presentation and operative characteristics, except for lower hemoglobin in the non-PBD group (10.9 ± 1.6 vs 11.8 ± 1.6 in the PBD group).Of the parameters assessing postoperative morbidity, incidence of wound infection was signif icantly less in the PBD than the non-PBD group [1 (2.9%) vs 12 (25.5%)]. However, the rest of the parameters did not differ signif icantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)]. There was no early mortality in either group. Median survival was 44 mo (95% CI: 34.2-53.8) in the PBD group and 41 mo (95% CI: 27.7-54.3; P = 0.86) in the non-PBD group. CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection. Overall mortality was not influenced by preoperative drainage. | Sheikh Anwar Abdullah Tarun Gupta Khairul Azhar Jaafar Yaw Fui Alexander Chung London Lucien Peng Jin Ooi Steven Joseph Mesenas | 2009 | World Journal of Gastroenterology2009，15，23： | 16 |
| 5 | ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13显示文摘这研究的目的是在房间增长和肺腺癌的 autophagy 调查 apelin 的角色。在肺腺癌的 APJ 的在表示上被 immunohistochemistry 检测,当在肺癌症病人的血浆 apelin 水平被连接酶的 immunosorbent 试金测量时。我们的调查结果表明 apelin-13 显著地增加了 ERK1/2 的 phosphorylation, cyclin D1 的表示,联系微导管的蛋白质 1 轻链 3A/B (LC3A/B ) ,和 beclin1,并且证实 apelin-13 支持了 A549 房间增长并且经由 ERK1/2 发信号导致了 A549 房间 autophagy。而且,人的肺腺癌房间线 A549 的表面和光滑、光滑的 apelin-13 原因房间表面上有毛孔是在原子力量下面观察了显微镜学。这些结果建议 ERK1/2 发信号小径调停 apelin-13-induced 肺腺癌房间增长和 autophagy。在我们的试验性的条件下面,与 3-methyladenine 联系的 autophagy 不涉及房间增长。 | Li Yang Tao Su Deguan Lv FengXie Wei Liu Jiangang Cao Irshad Ali Sheikh Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 15 |
| 6 | Multi-modality imaging review of congenital abnormalities of kidney and upper urinary tract显示文摘Congenital abnormalities of the kidney and urinary tract(CAKUT) include a wide range of abnormalities ranging from asymptomatic ectopic kidneys to life threatening renal agenesis(bilateral). Many of them are detected in the antenatal or immediate postnatal with a significant proportion identified in the adult population with varying degree of severity. CAKUT can be classified on embryological basis in to abnormalities in the renal parenchymal development, aberrant embryonic migration and abnormalities of the collecting system. Renal parenchymal abnormalities include multi cystic dysplastic kidneys, renal hypoplasia, number(agenesis or supernumerary), shape and cystic renal diseases. Aberrant embryonic migration encompasses abnormal location and fusion anomalies. Collecting system abnormalities include duplex kidneys and Pelvi ureteric junction obstruction. Ultrasonography(US) is typically the first imaging performed as it is easily available, noninvasive and radiation free used both antenatally and postnatally. Computed tomography(CT) and magnetic resonance imaging(MRI) are useful to confirm the ultrasound detected abnormality, detection of complex malformations, demonstration of collecting system and vascular anatomy and more importantly for early detection of complications like renal calculi, infection and malignancies. As CAKUT are one of the leading causes of end stage renal disease, it is important for the radiologists to be familiar with the varying imaging appearances of CAKUT on US, CT and MRI, thereby helping in prompt diagnosis and optimal management. | Subramaniyan Ramanathan Devendra Kumar Maneesh Khanna Mahmoud Al Heidous Adnan Sheikh Vivek Virmani Yegu Palaniappan | 2016 | World Journal of Radiology2016，8，2： | 13 |
| 7 | Early repolarization syndrome: A cause of sudden cardiac death显示文摘Early repolarization syndrome(ERS), demonstrated as J-point elevation on an electrocardiograph, was formerly thought to be a benign entity, but the recent studies have demonstrated that it can be linked to a considerable risk of life- threatening arrhythmias and sudden cardiac death(SCD). Early repolarization characteristics associated with SCD include high-amplitude J-point elevation, horizontal and/or downslopping ST segments, and inferior and/or lateral leads location. The prevalence of ERS varies between 3% and 24%, depending on age, sex and J-point elevation(0.05 m V vs 0.1 m V) being the main determinants.ERS patients are sporadic and they are at a higher risk of having recurrent cardiac events. Implantable cardioverter-defibrillator implantation and isoproterenol are the suggested therapies in this set of patients. On the other hand, asymptomatic patients with ERS are common and have a better prognosis. The risk stratification in asymptomatic patients with ERS still remains a grey area. This review provides an outline of the up-to-date evidence associated with ERS and the risk of life- threatening arrhythmias. Further prospective studies are required to elucidate the mechanisms of ventricular arrhythmogenesis in patients with ERS. | Abdi Ali Nida Butt Azeem S Sheikh | 2015 | World Journal of Cardiology2015，7，8： | 9 |
| 8 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 9 | 基于SMA和ECC复合材料的功能自恢复剪力墙抗震性能试验研究显示文摘剪力墙作为高层建筑广泛采用的水平抗侧力构件,承担着结构绝大部分的水平地震作用。因此,剪力墙受力性能的优劣对整个建筑结构的抗震性能尤为重要。为提高剪力墙的变形能力,减小剪力墙的损伤和残余变形,实现震后的快速恢复,提出一种具有自复位功能的剪力墙。在该剪力墙塑性铰区采用形状记忆合金筋(Shape Memory Alloy,简称SMA)替代纵向钢筋,实现墙体的自复位功能;采用工程水泥基复合材料(Engineered Cementitious Composites,简称ECC)替代普通混凝土,解决混凝土的脆性剥落损伤。为检验新型剪力墙的抗震性能,设计制作4个剪力墙试件,分别为普通混凝土剪力墙、高延性ECC增强剪力墙、超弹性SMA增强剪力墙和SMA和ECC共同增强剪力墙,并进行低周往复荷载试验,对比分析剪力墙的破坏模式以及承载力、自复位能力、延性、耗能能力等抗震性能。研究结果表明:与普通钢筋混凝土剪力墙相比,SMA和ECC共同增强剪力墙不仅损伤小,实现功能的快速修复,而且自复位能力达到85%以上,构件复位效果显著;同时表现出较好的延性。 | 钱辉 康莉萍 郭院成 李宗翱 Shamim A Sheikh | 2020 | 土木工程学报2020，53，10： | 8 |
| 10 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 11 | 复方玄驹胶囊对勃起功能障碍患者夜间阴茎勃起的影响显示文摘目的探讨复方玄驹胶囊对勃起功能障碍(ED)患者夜间阴茎勃起的作用。方法通过RigiScan阴茎硬度检测仪对门诊就诊的32例ED患者进行夜间阴茎勃起硬度和膨胀度(NPTR)检测,根据结果分为器质性ED(13例)和心理性ED(19例)两组。两组患者完成国际勃起功能指数-5(IIEF-5)评估后给予复方玄驹胶囊口服,一日3次,一次3g,用药4周后使用RigiScan再次复测NPTR及再次完成IIEF-5评估。比较用药前后NPTR参数变化,包括勃起次数、阴茎头部有效勃起的持续时间、阴茎周径变化、阴茎头/根部硬度活动单位(RAU)及膨胀活动单位(TAU)以及IIEF-5评分变化情况。结果服用复方玄驹胶囊4周后,器质性ED组患者夜间勃起次数、阴茎头部有效勃起的持续时间、阴茎周径变化,以及阴茎头/根部RAU及TAU均有显著改善(P<0.05);心理性ED组患者阴茎头部有效勃起的持续时间、平均勃起次数、阴茎周径变化有显著改善(P<0.05),但头/根部的RAU及TAU与治疗前比较无统计学差异(P>0.05)。器质性ED组治疗后IIEF-5评分显著改善[(7.5±2.1)vs.(5.9±1.6),P<0.05],但心理性ED组治疗前后无统计学差异[(14.6±5.0)vs.(13.5±4.2),P>0.05]。结论复方玄驹胶囊可改善器质性ED患者和心理性ED患者的夜间阴茎勃起状况。 | Muhiyadin Sheikh Ali 陈超豪 张磊 顾希杰 范来来 陈映鹤 | 2019 | 生殖医学杂志2019，28，3： | 8 |
| 12 | 在孟加拉国的不含酒精的脂肪肝疾病病人的不含酒精的 steatohepatitis显示文摘 AIM: To explore the prevalence and risk factors for nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD) patients. METHODS: We have included 493 patients with sonographic evidence of a fatty change, and 177 of these individuals were evaluated and confirmed after liver biopsy. The exclusion criteria consisted of significant alcohol abuse (< 20 g daily), evidence of hepatitis B and C, evidence of drug-induced fatty liver disease and other specific liver diseases such as hemochromatosis, Wilson’s disease or autoimmune liver disease. The patients were assessed for metabolic syndrome, and biochemical, anthropometric and histopathological evaluations were carried out. The degree of disease activity in the NAFLD patients was evaluated using the NAFLD Activity Score. The data were analyzed by SPSS, version 16.0. RESULTS: Females predominated among the study participants (250, 57.0%), and the mean age was 40.8 ± 10.2 years. The numbers of overweight, obeseⅠ and obese Ⅱ patients were 58 (13.2%), 237 (53.9%) and 93 (21.2%), respectively. However, there were 422 (96.2%) centrally obese patients. NASH was absent in 10 (5.6%) cases, borderline in 92 (52.6%) cases and present in 75 (42.4%) cases. The presence of diabetes could significantly (P = 0.001) differentiate NASH from simple steatosis. The following parameters did not influence the development of NASH: age, sex, basal metabolic index, waist circumference, serum high-density lipoprotein, triglyceride, insulin resistance index, hypertension and metabolic syndrome. The serum gammaglutamyl transpeptidase (GGT) level was significantly higher (P = 0.05, 51.7 ± 32.8 and 40.4 ± 22.6 U/L) in the NASH patients, with a sensitivity of 45% and a specificity of only 68%. The serum alanine aminotransferase and aspartate aminotransferase levels were not able to predict NASH. CONCLUSION: Females were the predominant sufferers of NAFLD in Bangladesh. The prevalence of NASH was high. Diabetes was found to be the main culprit in developing NASH. GGT was the only biochemical marker of NASH. We recommend liver biopsy in NAFLD patients who have diabetes and elevated GGT. | Shahinul Alam Sheikh Mohammad Noor-E-Alam Ziaur Rahman Chowdhury Mahabubul Alam Jahangir Kabir | 2013 | World Journal of Hepatology2013，5，5： | 7 |
| 13 | Production of carbide-free thin ductile iron castings显示文摘The fast cooling rate of thin ductile iron castings requires special consideration to produce carbide-free castings. Extraor-dinary care was taken to select the charge to produce castings of 100-mm long round bars with 16-mm diameter. The castings show the presence of carbides in the bars. Seven melts were made with different temperatures and with different compositions to get rid of carbides. After chemical analyses,it was found that the extra purity of the charge with less than 0.008wt% sulfur in the castings was the cause of carbides. To remove the carbides from the castings,sulfur should be added to the charge. | M. Ashraf Sheikh | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 7 |
| 14 | Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms显示文摘In environmental risk assessments(ERA), biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes(e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function). To mitigate these limitations, the concept of adverse outcome pathways(AOPs) was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event(MIE) to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo(a)pyrene(Ba P), silver nanoparticles(Ag NPs), and selenium(Se). Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem. | Jin Wuk Lee Eun-Ji Won Sheikh Raisuddin Jae-Seong Lee | 2015 | Journal of Environmental Sciences2015，27，9： | 7 |
| 15 | Advances in healthcare wearable devices显示文摘Wearable devices have found numerous applications in healthcare ranging from physiological diseases,such as cardiovascular diseases,hypertension and muscle disorders to neurocognitive disorders,such as Parkinson’s disease,Alzheimer’s disease and other psychological diseases.Different types of wearables are used for this purpose,for example,skin-based wearables including tattoobased wearables,textile-based wearables,and biofluidic-based wearables.Recently,wearables have also shown encouraging improvements as a drug delivery system;therefore,enhancing its utility towards personalized healthcare.These wearables contain inherent challenges,which need to be addressed before their commercialization as a fully personalized healthcare system.This paper reviews different types of wearable devices currently being used in the healthcare field.It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices(HWDs)for diagnostic and treatment purposes.Additionally,current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed. | Sheikh M.A.Iqbal Imadeldin Mahgoub E Du Mary Ann Leavitt Waseem Asghar | 2021 | npj Flexible Electronics2021，5，1： | 6 |
| 16 | 西藏中拉萨地块西段左左乡晚侏罗世-早白垩世花岗岩年代学、地球化学与岩石成因显示文摘近年来对青藏高原中拉萨地块西部中生代岩浆作用的源区、成因和演化等问题的研究较少。本文针对中拉萨地块西部噶尔县左左乡两个中酸性岩体进行了岩石学、锆石U-Pb年代学、微量元素和锆石Hf同位素,以及主量元素和微量元素地球化学研究。左左乡北侧岩体寄主花岗闪长岩和闪长质包体获得同期(163Ma和160Ma)的年龄,属于晚侏罗世;南侧岩体花岗岩年龄为142~147Ma,属于早白垩世。北侧与南侧的中酸性岩石均属于准铝质-弱过铝质高钾钙碱性I型花岗岩,富集大离子亲石元素和轻稀土元素,亏损高场强元素。晚侏罗世岩体寄主岩具有较为富集的锆石Hf同位素成分(ε_(Hf)(t)=-16.8~-13.6),可能来源于古老下地壳的部分熔融;包体具有相似的Hf同位素成分(ε_(Hf)(t)=-15.7~-13.6),结合晚侏罗世寄主岩与包体较高的MgO(4.13%~6.90%)、Cr(146×10^(-6)~370×10^(-6))和Ni(31×10^(-6)~113×10^(-6))含量,说明包体代表的中基性岩浆可能源于古老富集地幔的熔融,并且在晚侏罗世寄主花岗闪长岩与闪长质包体所代表的两种岩浆间发生过充分的岩浆混合作用。南侧早白垩世花岗岩具有较负且变化范围大的ε_(Hf)(t)值(-8.2~-4.8和-3.8~+0.2),指示早白垩世岩浆活动中有更多亏损地幔物质或新生地壳物质的加入,并且亏损地幔物质或新生地壳物质与拉萨地块古老地壳物质熔融形成的酸性岩浆发生了岩浆混合,经历岩浆混合后中酸性岩浆又发生了角闪石、长石的分离结晶,最终形成南侧早白垩世岩体的一系列中酸性岩石。研究区早白垩世亏损地幔物质或新生地壳物质的增多可能与南向俯冲的班公湖-怒江板片的回转有关。 | 齐宁远 赵志丹 唐演 闫晶晶 石卿尚 刘栋 朱弟成 SHEIKH Lawangin | 2019 | 岩石学报2019，35，2： | 6 |
| 17 | 经络系统与针刺效应机制的科学评价显示文摘Objective:To search all available sources to find incontrovertible scientific explanation of the meridian system and mechanism of acupuncture action.Methods:Extensive search of electronic databases was carried out to identify all published scientific articles,research papers and experimental findings regarding meridian system,acupuncture points and mechanisms of acupuncture action,from both English and Chinese language journals,from inception till date.Results:There are many hypotheses and studies about meridian system such as,primovascular system as meridian,nuclear tracers study to locate the track of meridian,infrared imaging studies to prove existence of meridians,investigations about anatomical structure of acupoints,etc.There are many researches and theories about mechanism of acupuncture action such as gate control theory of acupuncture analgesia,neurotransmitters,neuro-endocrine-immune network,fMRI evidences of brain’s processing of pain signal etc.Conclusion:Researchers over half a century discovered many factual information about meridian system,acupoints,neuro-transmitters and acupuncture analgesia,neuro-hormonal mechanism etc.All these important discoveries contributed to clarify the mysteries of meridian system and acupuncture action,but they still fell short of providing an incontrovertible scientific explanation.Further coordinated studies are warranted to explore more plausible and scientifically valid explanation of meridian system and acupuncture action. | 毛慧娟 赵玲 沈雪勇 | 2020 | World Journal of Acupuncture-Moxibustion2020，30，2： | 5 |
| 18 | Thermo-diffusion effects on MHD stagnation point flow towards a stretching sheet in a nanofuid显示文摘Thermodiffusion effects on stagnation point flow of a nanofuid towards a stretching surface with applied magnetic field is presented.Similarity transforms are applied to reduce the equations that govem the flow to a system of nonlinear ordinary differential equations.Runge-K utta-Fehlberg method is applied to solve the sy stem.Results are compared with existing solutions that are special cases to our problem.Concrete graphical analysis is carried out to study the effects of different emerging parameters such as stretching ratio A,mag netic infuence parameter M,Prandtl number Pr,Lewis number Le,Brownian motion parameter Nb,thermophoresis parameter Nr,nanofluid Lewis number Ln,modified Dufour parameter Nd and Dufour solutal number Ld coupled with comprehensive discussions.Numerical effects of local Nusselt number,local Sherwood number and nanofluid Sherwood number are also discussed. | Umar Khan Naveed Ahmed Sheikh Irfan Ullah Khan Syed Taluseef Mohyud-din | 2014 | Propulsion and Power Research2014，3，3： | 5 |
| 19 | HBsAg, HBcAg, and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection显示文摘BACKGROUND: As the host immunity is diminished in patients with chronic hepatitis B (CHB), different approaches have been used to up-regulate their immune responses to produce therapeutic effects. But, cytokines, growth factors and polyclonal immune modulators could not exhibit sufficient therapeutic effects in these patients. Immune therapy with HBV-related antigens (vaccine therapy) has been used in CHB patients. But there is a paucity of information about the design of HBV antigen-based immune therapy in these patients. DATA SOURCE: Preclinical and clinical studies on immune therapy with HBsAg-based vaccine, HBcAg and combination of HBsAg/HBcAg-based vaccines have been discussed. RESULTS: HBsAg-based prophylactic vaccine was used as an immune therapeutic agent in CHB patients; however, monotherapy with HBsAg-based immune therapy could not lead to sustained control of HBV replication and/or liver damages. HBsAg-based vaccine was used as a combination therapy with cytokines, growth factors, and antiviral drugs. HBsAg-based vaccine was also used for cell-based therapy. However, satisfactory therapeutic effects of HBsAg-based vaccine could not be documented in CHB patients. In the mean time, evidences have supported that HBcAg-specific immunity is endowed with antiviral and liver protecting capacities in CHB patients. Recent data concentrate on the clinical use of combined HBsAg- and HBcAg-based vaccines in CHB patients.CONCLUSION: Antigen-based immune therapy with HBV- related antigens may be an alternative method for the treatment of CHB patients but proper designs of antigens, types of adjuvants, dose of vaccinations, and routes of administration need further analyses for the development of an effective regimen of immune therapy against HBV. | Sheikh Mohammad Fazle Akbar Mamun Al-Mahtab Mohammad Helal Uddin Md. Sakirul Islam Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 5 |
| 20 | Post-traumatic stress disorder among paramedic and hospital emergency personnel in south-east Iran显示文摘BACKGROUND:Paramedic and emergency personnel may encounter directly many events that threat their own wellbeing during their daily work.This study was conducted to examine the prevalence rate of post-traumatic stress disorder(PTSD) among two groups of paramedic and emergency personnel in south-east Iran.METHODS:The study employed a descriptive design and was conducted in four hospital emergency wards and a pre-hospital emergency base supervised by Kerman Medical University.Using Mississippi PTSD,we assessed the prevalence rate in paramedics(n=150) and emergency personnel(n=250).RESULTS:The two groups had different levels of education,marital status,experience of traumatic events,work hours per month,and gender.Most(94%) of paramedic and hospital emergency personnel reported moderate PTSD.The two groups had significant different levels of PTSD in all subscale.CONCLUSION:The study suggests that health care managers should organize systematic and dynamic policies and procedures in dealing with PTSD to assist both groups of personnel. | Sedigheh Iranmanesh Batool Tirgari Hojat Sheikh Bardsiri | 2013 | World Journal of Emergency Medicine2013，4，1： | 5 |
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