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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Renal cell carcinoma: Evolving and emerging subtypes显示文摘Our knowledge of renal cell carcinoma(RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and defined, and our understanding of the biology and clinical correlates of these tumors is changing. Evolving concepts in Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and carcinoma associated with neuroblastoma are addressed within this review. Tubulocystic carcinoma, thyroid-like follicular carcinoma of kidney, acquired cystic disease-associated RCC, and clear cell papillary RCC are also described. Finally, candidate entities, including RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor are reviewed. Knowledge of these new entities is important for diagnosis, treatment and subsequent prognosis. This review provides a targeted summary of new developments in RCC. | Suzanne M Crumley Mukul Divatia Luan Truong Steven Shen Alberto G Ayala Jae Y Ro | 2013 | World Journal of Clinical Cases2013，1，9： | 7 |
| 3 | 二硫戊环衍生物和类似物的合成及其iNOS/PAF双重抑制剂活性(英文)显示文摘目的 :研究双重作用的新型抗炎药物。方法 :合成二硫戊环衍生物和类似物 ,研究这些化合物及选择性的PAF受体拮抗剂L6 5 9,989对PAF受体的结合 ,和对IFN γ或LPS诱导的NO生成 ,以及对iNOSmRNA表达的影响。结果 :合成了 4 0个新化合物 ,其中 19个在不同程度上抑制NO生成。选择 3个活性最高的化合物 (2 ,19,2 0 )进行深入研究 ,发现它们能抑制iNOSmRNA的表达 ,其抑制NO生成的效力从高到低依次为 :19,2 0 ,2 ,L6 5 9,989,其拮抗PAF受体的活性从高到低依次为 :L6 5 9,989,2 0 ,2 ,19。L6 5 9,989对NO生成和iNOSmRNA表达无影响。受试物的PAF受体拮抗活性与iNOS抑制活性之间无简单关联。结论 :二硫戊环类化合物是iNOS表达的新型调控剂 ,其中一些具有抑制iNOS的诱导和拮抗PAF受体的双重活性。 | 张奕华 HUSSAINI Isa M SHEN Tsung Y | 2003 | 中国药科大学学报2003，34，3： | 2 |
| 4 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 5 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 6 | True phosphorus digestibility and the endogenous phosphorus outputs associated with corn for growing pigs are determined with the regression analysis technique显示文摘 | Shen Y R Fan M Z Ajakaie A | 2002 | Journal of Nutrition2002，132，： | 1 |
| 7 | Atom transfer radical polymerization of 2-(dimethylamino)ethyl methacrylate in aqueous media 显示文摘 | Zeng F Shen Y Zhu S et M | 2000 | Polym Sci Part A: Polym Chem2000，38，20： | 1 |
| 8 | Production of tetraploid pearl oyster (Pinctada martensii Dunker) by inhibiting the first polar body in eggs from triploids 显示文摘 | He M Lin Y Shen Q | 2000 | Journal of Shellfish Research2000，19，1： | 1 |
| 9 | Plant proteomics in the post-genomic era显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Acta Bot Sin2002，44，6： | 1 |
| 10 | Correlation of Effective Temporal Resolution and Accuracy of Volume Ejection Fraction on the ECG-gated Cardiac MDCT 显示文摘 | Shen Y Jinzaki M | 2005 | Nippon acta radiologica2005，65，： | 1 |
| 11 | The Influence of retained austenite in high chromium cast iron on impact-abrasive wear显示文摘 | TONG J M ZHOU Y Z SHEN T Y and DENG H J | 1990 | Wear1990，135，2： | 1 |
| 12 | Chinese SF - 36 Health Survey: translation, cultural adaptation, validation, and normalization 显示文摘 | L Li H M Wang Y Shen | 2003 | Journal of Epidemlology and Community Health2003，57，： | 1 |
| 13 | Carbohydrates from Cynanchum otophyllum 显示文摘 | Zhao Y B Shen Y M He H P | 2004 | Carbohydrate Research2004，339，11： | 1 |
| 14 | Application of independ- ent component analysis to AC dipole based optics meas- urement and correlation at the relativistic heavy ion colli- der 显示文摘 | Shen X Lee S Y Bai M | 2013 | Physical Review Special Topics : Accelerators and Beams2013，16，11： | 1 |
| 15 | Penicidones A-C,three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp显示文摘 | GE H M SHEN Y ZHU C H | 2008 | Phytochemistry2008，69，2： | 1 |
| 16 | Adsorption separa- tion of carbon dioxide from flue gas by a molecularly imprinted adsorbent 显示文摘 | Zhao Y Shen Y M Ma G Y | 2014 | Environmental Science & Technology2014，48，3： | 1 |
| 17 | Aflatoxin B1-induced lipid peroxidation in rat liver显示文摘 | SHEN H M SHI C Y LEE H P | 1994 | Toxicology and Applied Pharmacology1994，127，1： | 1 |
| 18 | Leucinepromotes proliferation and differentiation of primary preterm rat satelliteeells in part through mTORC1 signaling pathway 显示文摘 | Dai J M Yu M X Shen Z Y | 2015 | Nutrients2015，7，5： | 1 |
| 19 | Discrimination of different ganoderma species and their region based on GC-MS profiles of sterols and pattern recognition techniques显示文摘 | Shen M Y Xie M Y Nie S P | 2011 | Anal Lett2011，44，5： | 1 |
| 20 | An interval maximum entropy method for a discrete minimax problem显示文摘 | Shen Z H Huang Z Y Wolfe M A | 1997 | Applied Math & Comput1997，87，1： | 1 |
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