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| 1 | Microsatellite instability,MMR gene expression and proliferation kinetics in colorectal cancer with famillial predisposition显示文摘INTRODUCTIONGenetic instability is a conunon property of manyhuman cancers,including those of HNPCC.A novel form of genetic instability involving somaticalterations,such as deletions and insertions insimple repeated sequences,has been found.Microsatellitcs are relatively short runs of tandemlyrepeated sequences scattered throughout | Bao Ping Wu Ya Li Zhang Dian Yuan Zhou Chun Fang Gao Zhuo Sheng Lai | 2000 | World Journal of Gastroenterology2000，6，6： | 14 |
| 2 | Inner wrinkling control in hydrodynamic deep drawing of an irregular surface part using drawbeads显示文摘Inner wrinkling phenomenon is more likely to develop during hydrodynamic deep drawing(HDD) of complicated component-forms due to the higher demand for controlling deformation sequences. Aiming at the problems in control of inner wrinkling for an irregular surface part featured with both concavity and convex, this research proposes an optimal design method of drawbead parameters to change the material flow. According to theoretical analysis of the mechanism of inner wrinkling, optimizing cavity pressure only is unreasonable to form a wrinkle-free deep-drawn part,so semi-circular drawbeads are employed. The effects of layout and height of drawbeads on forming results are discussed, and a process window is established based on evaluation indicators including the anti-wrinkle coefficient and the minimum wall thickness. Experiments are carried out to validate the process window, and the wall thickness and the wrinkle height are measured and compared with numerical findings. The results show that the anti-wrinkle ability of drawbeads weakens with increasing oblique angle and distance from the die center, while the wall thickness increases with increasing oblique angle and distance, and the inner wrinkling can be completely suppressed by drawbeads arranged in zones I and II with optimum penetration. | Meng Bao Wan Min Wu Xiangdong Yuan Sheng Xu Xudong Liu Jie | 2014 | Chinese Journal of Aeronautics2014，27，3： | 14 |
| 3 | Increase of TNFα-stimulated Osteoarthritic Chondrocytes Apoptosis and Decrease of Matrix Metalloproteinases 9 by NF-κB Inhibition显示文摘Objective To investigate the in vitro effect of caffeic acid phenethyl ester(CAPE),a NF-κB inhibitor,on the apoptosis of osteoarthritic(OA)chondrocytes and on the regulation of the gelatinases matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9).Methods Annexin V-FITC/propidium iodide(PI)labeling and western blotting were used to observe and determine the apoptosis in TNFα-stimulated primary cultured osteoarthritic chondrocytes.Also,gelatin zymography was applied to examine MMP-2 and MMP-9 activities in supernatants.Results It was confirmed by both flow cytometry and western blotting that chondrocytes from OA patients have an apoptotic background.Use of CAPE in combination with 10 ng/mL of TNFα for 24 h facilitated the apoptosis.MMP-9 in the supernatant could be autoactivated(from proMMP-9 to active MMP-9),and the physiologic calcium concentration(2.5 mmol/L)could delay the autoactivation of MMP-9.The activities of MMP-2 and MMP-9 in the fresh supernatant increased significantly in response to stimulation by 10 ng/mL of TNFα for 24 h.The stimulatory effect of TNFα just on proMMP-9 was counteracted significantly by CAPE.Conclusion NF-κB could prevent chondrocytes apoptosis though its activation was attributed to the increase of proMMP-9 activity induced by TNFα(a pro-apoptotic factor).Therefore,therapeutic NF-κB inhibitor was a 'double-edged swords' to the apoptosis of chondrocytes and the secretion of MMP-9. | WANG Yan LI De Ling ZHANG Xin Bo DUAN Yuan Hui WU Zhi Hong HAO Dong Sheng CHEN Bao Sheng QIU Gui Xing | 2013 | Biomedical and Environmental Sciences2013，26，4： | 13 |
| 4 | Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome显示文摘AIM To investigate the performance of transient elastography(TE) for diagnosis of fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis(AIHPBC) overlap syndrome.METHODS A total of 70 patients with biopsy-proven AIH-PBC overlap syndrome were included. Spearman correlation test was used to analyze the correlation of liver stiffness measurement(LSM) and fibrosis stage. Independent samples Student's t-test or one-way analysis of variance was used to compare quantitative variables. Receiver operating characteristics(ROC) curve was used to calculate the optimal cut-off values of LSM for predicting individual fibrosis stages. A comparison on the diagnostic accuracy for severe fibrosis was made between LSM and other serological scores.RESULTS Patients with AIH-PBC overlap syndrome had higher median LSM than healthy controls(11.3 ± 6.4 k Pa vs 4.3 ± 1.4 k Pa, P < 0.01). LSM was significantly correlated with fibrosis stage(r = 0.756, P < 0.01). LSM values increased gradually with an increased fibrosis stage. The areas under the ROC curves of LSM for stages F ≥ 2, F ≥ 3, and F4 were 0.837(95%CI: 0.729-0.914), 0.910(0.817-0.965), and 0.966(0.893-0.995), respectively. The optimal cut-off values of LSM for fibrosis stages F ≥ 2, F ≥ 3, and F4 were 6.55, 10.50, and 14.45 k Pa, respectively. LSM was significantly superior to fibrosis-4, glutaglumyl-transferase/platelet ratio, and aspartate aminotransferase-to-platelet ratio index scores in detecting severe fibrosis(F ≥ 3)(0.910 vs 0.715, P < 0.01; 0.910 vs 0.649, P < 0.01; 0.910 vs 0.616, P < 0.01, respectively).CONCLUSION TE can accurately detect hepatic fibrosis as a noninvasive method in patients with AIH-PBC overlap syndrome. | Hui-Min Wu Li Sheng Qi Wang Han Bao Qi Miao Xiao Xiao Can-Jie Guo Hai Li Xiong Ma De-Kai Qiu Jing Hua | 2018 | World Journal of Gastroenterology2018，24，6： | 13 |
| 5 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 6 | Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry显示文摘在这份报纸,高效的液体层析结合了紫外察觉, Fourier 变换离子回旋加速器回声团 spectrometry (HPLCUV/FTICRMS ) 方法在 moxifloxacin (MOX ) 为杂质侧面的调查被描述药物质和化学参考书物质。十杂质被 HPLCUV 检测,当八杂质被使用与多重阶段的集体度谱的数据和破碎规则相结合的高精确的分子的团识别时。到我们的知识,另外,五杂质在 MOX 药物质第一次被成立。 | Cai Sheng Wu Zhi Xin Jia Bao Ming Ning Jin Lan Zhang Song Wu | 2012 | Chinese Chemical Letters2012，23，10： | 8 |
| 7 | A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea显示文摘A new ureido-substituted amino acid,conopsamide A(1),has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea.Its structure was elucidated by extensive spectroscopic analysis,and the absolute configuration was assigned by Marfey's method.The new compound was evaluated for in vitro assay for HDACl(Histone Deacetylase 1) inhibitory activity. | Peng-Cheng Lin Jing Yao Jiang Wu Jin Tian Yi Bao Sheng Lin | 2017 | Chinese Chemical Letters2017，28，2： | 7 |
| 8 | A novel approach to treat combined domestic wastewater and excess sludge in MBR显示文摘Domestic wastewater was treated by combined anaerobic biofilm aerobic membrane bioreactor(MBR) process, and part biomass in MBR was withdrawn to treat with ozone, then the ozonated sludge was returned to anaerobic inlet. In aerobic MBR, MLSS and DO were controlled at 3000—3500 mg/L and 0 8 mg/L respectively. Comparing the experimental results of two stages, it was noticed that ozonation did not affect the removal efficiency for organics but had a significant influence on the removals of NH 3 N and TN. During the ozonation period of two months, no excess sludge was wasted, and a zero sludge yield was obtained. | HE Sheng bing, WANG Bao zhen, WANG Lin, JIANG Yi feng, ZHANG Li\|qiu (School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China. | 2003 | Journal of Environmental Sciences2003，15，5： | 6 |
| 9 | Influences of accumulated mileage and technological changes on emissions of regulated pollutants from gasoline passenger vehicles显示文摘In this study, the influences of accumulated mileage(deterioration) and technological changes(emission standards) on emission factors(EFs) of regulated pollutants(CO, HC, and NO_x) from gasoline passenger vehicles were investigated based on Inspection and Maintenance(I/M) data using the chassis dynamometer method. The accumulated mileage of passenger vehicles was significantly linearly correlated with vehicle age. For most cases,the average EFs of CO, HC and NO_x were significantly linearly correlated with accumulated mileage, indicating that emission deterioration had a significant impact on pollutant EFs.Implemented emission standards markedly influenced the EFs of regulated pollutants, and EFs markedly decreased with progressing emission standards. The present study also compared EFs of regulated pollutants between this study and the International vehicle emission(IVE) model, and marked differences in EFs were seen with variations in emission standards, vehicle types and accumulated mileage; NO_x EFs in this study were higher than in the IVE model. The results provide new insight into estimating regulated pollutant emissions using the IVE model. | Qingyu Zhang Juwang Fan Weidong Yang Fang Ying Zhen Bao Yi Sheng Cheng Lin Xuan Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 5 |
| 10 | Simultaneous determination of seven flavonoids in Epimedium by liquid chromatography-tandem mass spectrometry method显示文摘In this paper,a sensitive and specific liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) method has been developed and validated for the identification and determination of seven flavonoids,namely epimedin A,epimedin B, epimedin C,icariin,sagittatoside B,2″-O-rhamnosyl icarisideⅡ,and baohuosideⅠin Epimedium from different sources. | Cai Sheng Wu Bao Lin Guo Yu Xin Sheng Jin Lan Zhang | 2008 | Chinese Chemical Letters2008，19，3： | 5 |
| 11 | A Novel Sesquiterpenoid from Glechoma longituba显示文摘A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7(11)-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences. | Qian Jun ZHANG Xiao Sheng YANG Hal Yan ZHU Ye WANG Xiao Jiang HAO Bao An SONG | 2006 | Chinese Chemical Letters2006，17，3： | 5 |
| 12 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 13 | Source of blood supply of liver cavernous hemangioma and sclerosis and embolization treatment显示文摘SourceofbloodsupplyoflivercavernoushemangiomaandsclerosisandembolizationtreatmentLIGouWei1,ZHAOZhongRong2,LIBaoSheng1,LI... | LI Gou Wei 1, ZHAO Zhong Rong 2, LI Bao Sheng 1, LIU Xiao Gong 1, WANG Zhi Liang 1 and LIU Qing Feng 1 | 1997 | World Journal of Gastroenterology1997，3，3： | 4 |
| 14 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 15 | CAS FGOALS-f3-L Model Datasets for CMIP6 GMMIP Tier-1 and Tier-3 Experiments显示文摘The Chinese Academy of Sciences(CAS)Flexible Global Ocean Atmosphere Land System(FGOALS-f3-L)model datasets prepared for the sixth phase of the Coupled Model Intercomparison Project(CMIP6)Global Monsoons Model Intercomparison Project(GMMIP)Tier-1 and Tier-3 experiments are introduced in this paper,and the model descriptions,experimental design and model outputs are demonstrated.There are three simulations in Tier-1,with different initial states,and five simulations in Tier-3,with different topographies or surface thermal status.Specifically,Tier-3 contains four orographic perturbation experiments that remove the Tibetan Iranian Plateau,East African and Arabian Peninsula highlands,Sierra Madre,and Andes,and one thermal perturbation experiment that removes the surface sensible heating over the Tibetan Iranian Plateau and surrounding regions at altitudes above 500 m.These datasets will contribute to CMIP6’s value as a benchmark to evaluate the importance of long-term and short-term trends of the sea surface temperature in monsoon circulations and precipitation,and to a better understanding of the orographic impact on the global monsoon system over highlands. | Bian HE Yimin LIU Guoxiong WU Qing BAO Tianjun ZHOU Xiaofei WU Lei WANG Jiandong LI Xiaocong WANG Jinxiao LI Wenting HU Xiaoqi ZHANG Chen SHENG and Yiqiong TANG | 2020 | Advances in Atmospheric Sciences2020，37，1： | 4 |
| 16 | Boosting triplet self-trapped exciton emission in Te(IV)-doped Cs_(2)SnCl_(6) perovskite variants显示文摘Perovskite variants have attracted wide interest because of the lead-free nature and strong self-trapped exciton (STE) emission. Divalent Sn(II) in CsSnX3 perovskites is easily oxidized to tetravalent Sn(IV), and the resulted Cs2SnCl6 vacancy-ordered perovskite variant exhibits poor photoluminescence property although it has a direct band gap. Controllable doping is an effective strategy to regulate the optical properties of Cs2SnX6. Herein, combining the first principles calculation and spectral analysis, we attempted to understand the luminescence mechanism of Te4+-doped Cs2SnCl6 lead-free perovskite variants. The chemical potential and defect formation energy are calculated to confirm theoretically the feasible substitutability of tetravalent Te4+ ions in Cs2SnCl6 lattices for the Sn-site. Through analysis of the absorption, emission/excitation, and time-resolved photoluminescence (PL) spectroscopy, the intense green-yellow emission in Te4+:Cs2SnCl6 was considered to originate from the triplet Te(IV) ion 3P1→1S0 STE recombination. Temperature-dependent PL spectra demonstrated the strong electron-phonon coupling that inducing an evident lattice distortion to produce STEs. We further calculated the electronic band structure and molecular orbital levels to reveal the underlying photophysical process. These results will shed light on the doping modulated luminescence properties in stable lead-free Cs2MX6 vacancy-ordered perovskite variants and be helpful to understand the optical properties and physical processes of doped perovskite variants. | Ruosheng Zeng Kun Bai Qilin Wei Tong Chang Jun Yan Bao Ke Jialuo Huang Liushun Wang Weichang Zhou Sheng Cao Jialong Zhao Bingsuo Zou | 2021 | Nano Research2021，14，5： | 4 |
| 17 | Synthesis of phenol-class azo derivatives of 4-aminosalicylic acid显示文摘对煽动性的肠疾病与更高的活动和更少的副作用探索 4-aminosalicylic 酸(4-ASA ) 的更好的职业人员药。在合成过程的继任以后, 4-ASA 与各种各样的搬运人分子被结合得到 4-ASA 的七偶氮的衍生物。所有混合物被英尺红外描绘, 1H NMR, 13C NMR spectras 详细。4-ASA 的新衍生物是 definituded。 | Shi Fei Sheng Hui Xia Zheng Jiang Liu Zheng Bao Zhao | 2008 | Chinese Chemical Letters2008，19，4： | 4 |
| 18 | Synthesis of a hypocrellin B-polyamide conjugate as DNA-targeting photosensitizer显示文摘A new hypocrellin B (HB) derivative bearing a bispyrrolecarboxamide-containing side chain was synthesized, which presents improved absorptivity in phototherapeutic window than HB and affinity feature towards dsDNA. | Yan Yan Liu Sheng Qin Xia Zhang Hua Zeng Rui Qiao Xue Song Wang Bao Wen Zhang | 2008 | Chinese Chemical Letters2008，19，2： | 3 |
| 19 | Social Manufacturing for High-end Apparel Customization显示文摘Social manufacturing(SM), a novel distributed,collaborative and intelligent manufacturing mode, is proposed and developed for high-end apparel customization. The main components of SM cloud are designed, and its research topics are summarized. Then, SM's key technologies are studied. 3D technologies for apparel customization, like 3D modeling, 3D fitting mirror and 3D customization, are developed to improve the customization precision and user experience. Information based collaborative management is realized to share, communicate,and handle the information efficiently among all groups and individuals of SM cloud. Suppliers' evaluation mechanism is designed to support the optimal decisions making. Next, SM cloud is constructed in five layers for high-end apparel customization.By using SM cloud based crowd-sourcing, social resources can be allocated rationally and utilized efficiently, consumer can customize the product in any processes like innovation, design,making, marketing and service, and traditional apparel enterprise can be upgraded into SM mode for keeping it competitive in the future customization markets. | Xiuqin Shang Fei-Yue Wang Gang Xiong Timo R. Nyberg Yong Yuan Sheng Liu Chao Guo Sen Bao | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 3 |
| 20 | Two new diterpenoids from Rabdosia japonica var. glaucocalyx显示文摘分别地,二新 diterpenoids,命名 glaucocalyxin F 和 glaucocalyxin X 从 Rabdosia 装饰用的梨树的整个植物被孤立(Burm。f.) Hara var。glaucocalyx (格言) Hara。他们的结构被建立根据光谱分析。 | Zhao Bao Xiang Yi Xin Xu Yang Shen Li Jin Hou Peng Wang Hai Sheng Chen | 2008 | Chinese Chemical Letters2008，19，7： | 3 |
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