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| 1 | Experimental investigation on ice-breaking performance of a novel plasma striker显示文摘Aircraft icing has long been a plague to aviation for its serious threat to flight safety.Recently,researches about a newly proposed deicing method based on Plasma Synthetic Jet Actuator(PSJA)have just started.To meet the requirements of in-flight deicing,structure of PSJA needs to be adjusted.This paper completed the detailed design and experimental validation of a novel plasma striker,which was a modified version of PSJA.Influences of mass of the moving part and rod shapes on the ice-breaking performances were also studied.Besides,a“conical-nosed rod configuration”was proposed.Its purpose was to ensure a good ice-breaking performance of the plasma striker on long ice,by generating a splitting failure.Results show that,though mass of the moving part was just several grams,ice-breaking performance was better when the mass was lighter.The rectangular rod could generate an elliptical circumferential crack,whose major axis was parallel to the direction of the long side of the rectangular rod.And the“conical-nosed rod”concept was verified to be able to generate a splitting crack which can spread completely to the far end of long ice,and the crack direction was parallel to edge line of the cone.In general,the plasma striker has the advantages of simple structure,low energy consumption,little harm to the flow field and the aircraft skin.Simulations will be carried out in future works to study in detail the working process of the plasma striker. | Tianxiang GAO Zhenbing LUO Yan ZHOU Shengke YANG Wenqiang PENG Xiong DENG Pan CHENG | 2022 | Chinese Journal of Aeronautics2022，35，1： | 2 |
| 2 | Deep belief network-based drug identification using near infrared spectroscopy显示文摘Near infrared spectroscopy(NIRS)analysis technology,combined with chemometrics,can be effectively used in quick and nondestructive analysis of quality and category.In this paper,an effective drug identification method by using deep belief network(DBN)with dropout mecha-nism(dropout-DBN)to model NIRS is introduced,in which dropout is employed to overcome the overfitting problem coming from the small sample.This paper tests proposed method under datasets of different sizes with the example of near infrared diffuse refectance spectroscopy of erythromycin ethylsuccinate drugs and other drugs,aluminum and nonaluminum packaged.Meanwhile,it gives experiments to compare the proposed method's performance with back propagation(BP)neural network,support vector machines(SVMs)and sparse denoising auto-encoder(SDAE).The results show that for both binary classification and multi-classification,dropout mechanism can improve the classification accuracy,and dropout-DBN can achieve best classification accuracy in almost all cases.SDAE is similar to dropout-DBN in the aspects of classification accuracy and algorithm stability,which are higher than that of BP neural network and SVM methods.In terms of training time,dropout-DBN model is superior to SDAE model,but inferior to BP neural network and SVM methods.Therefore,dropout-DBN can be used as a modeling tool with effective binary and multi-class classification performance on a spectrum sample set of small size. | Huihua Yang Baichao Hu Xipeng Pan Shengke Yan Yanchun Feng Xuebo Zhang Lihui Yin Changqin Hu | 2017 | Journal of Innovative Optical Health Sciences2017，，2： | 1 |
| 3 | Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils显示文摘With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbit[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed. | Yiyun Gao Yan Gao Yuanfu Ding Huaping Tan Aihua Zou Shengke Li | 2021 | Chinese Chemical Letters2021，32，3： | 0 |
| 4 | Supramolecular nano drug delivery systems mediated via host-guest chemistry of cucurbit[n]uril(n=6 and 7)显示文摘As a novel family of macrocyclic molecules,cucurbit[n]urils(CB[n]s) have emerged as promising building blocks of supramolecular nano drug delivery systems(SNDDS) in recent years.Direct encapsulation of amphiphilic guests by CB[6] and CB[7] can modulate their amphiphilicity,resulting in formation of supramolecular amphiphiles that self-assemble into supramolecular nanoparticles for drug delivery.Additionally,CB[n]'s host-guest chemistry on the surface of mesoporous nanoparticles makes CB[n] an ideal blocking agent to control drug release from delivery vehicles.These SNDDS possess intrinsic stimuli responsiveness towards external guest or host,which can further incorporate re s ponsiveness to a variety of other stimuli including pH,thermal,redox,photo and enzyme,to realize multiple stimuli-responsive drug release.Moreover,the recent breakthrough in direct functionalization of CB[n]s has provided a feasible method for preparing superior CB[6] and CB[7] derivatives that can be employed to build multifunctional SNDDS with unoccupied macrocycles located on surface,which could be decorated with various functional 'tags' through host-guest chemistry.In this review,we summarized the recent progress of CB[6] and CB[7] based SNDDS through formation of supramolecular amphiphiles,supramolecular nanovalves as well as supramolecularly tailorable surface,which we hope to further promote the development of CB[n]s family as building blocks for advanced SNDDS. | Shengke Li Yan Gao Yuanfu Ding Anni Xu Huaping Tan | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
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