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您的检索式：作者名="Sherif Ramzy Mohamed"
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| 1 | DON生物合成的亚细胞定位和精准外排研究进展显示文摘单端孢霉烯B族毒素脱氧雪腐镰刀烯醇(deoxinivalenol,DON)是产毒镰刀菌在侵染小麦等作物过程中的一类重要的致病因子,可以帮助产毒镰刀菌在麦穗间扩展。DON会抑制蛋白质合成,对动物、微生物和寄主具有毒性(cytotoxicity and phytotoxicity),然而产毒镰刀菌自身借助何种保护机制免受DON毒害目前研究甚少。DON毒害机制的研究对于镰刀菌毒素的持续防控和粮食安全、人民生命健康保障具有重要意义。综述了产毒镰刀菌DON合成解毒机制的最新研究进展,主要包括DON合成的亚细胞定位、合成基因簇内的外排蛋白和解毒基因作用方式,以期为有针对性地破解其解毒机制,设计研发高效靶向控毒技术的相关研究提供参考。 | 刘馨 方欣 汪爽 王立雯 武德亮 LEE Yin Won MOHAMED Sherif Ramzy 徐剑宏 史建荣 | 2021 | 生物技术进展2021，11，5： | 0 |
| 2 | The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum显示文摘Production of the Fusarium toxin deoxynivalenol(DON)is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium graminearum.In this study,we found that the antioxidant methyl gallate(MG)displays inhibitory effects against mycelial growth,conidial formation and germination,and DON biosynthesis in F.graminearum in a dose-dependent manner.Treatment with 0.05%(w/v)MG resulted in an abnormal swollen conidial morphology.The expression of the TRI genes involved in DON biosynthesis was significantly reduced,and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated mycelium.RNA-Seq analysis of MG-treated F.graminearum showed that 0.5%(w/v)MG inhibited DON production by possibly altering membrane functions and oxidoreductase activities.Coupled with the observations that MG treatment decreases catalase,POD and SOD activity in F.graminearum.The results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative response.Taken together,the current study revealed the potential of MG in inhibiting mycotoxins in F.graminearum. | Xin Liu Xin Fang Shuang Wang Deliang Wu Tao Gao Yin-Won Lee Sherif Ramzy Mohamed Fang Ji Jianhong Xu Jianrong Shi | 2021 | Food Production, Processing and Nutrition2021，3，1： | 0 |
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