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| 1 | An overview of resistive random access memory devices显示文摘With recent progress in material science, resistive random access memory (RRAM) devices have attracted interest for nonvolatile, low-power, nondestructive readout, and high-density memories. Relevant performance parameters of RRAM devices include operating voltage, operation speed, resistance ratio, endurance, retention time, device yield, and multilevel storage. Numerous resistive-switching mechanisms, such as conductive filament, space-charge-limited conduction, trap charging and discharging, Schottky Emission, and Pool-Frenkel emission, have been proposed to explain the resistive switching of RRAM devices. In addition to a discussion of these mechanisms, the effects of electrode materials, doped oxide materials, and different configuration devices on the resistive-switching characteristics in nonvolatile memory applications, are reviewed. Finally, suggestions for future research, as well as the challenges awaiting RRAM devices, are given. | LI YingTao LONG ShiBing LIU Qi LU HangBing LIU Su LIU Ming | 2011 | Chinese Science Bulletin2011，56，28： | 9 |
| 2 | Dynamic edge-based biomarker non-invasively predicts hepatocellular carcinoma with hepatitis B virus infection for individual patients based on blood testing显示文摘Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths in Asia and Africa. Developing effective and non-invasive biomarkers of HCC for individual patients remains an urgent task for early diagnosis and convenient monitoring. Analyzing the transcriptomic profiles of peripheral blood mononuclear cells from both healthy donors and patients with chronic HBV infection in different states (i.e. HBV carrier, chronic hepatitis B, cirrhosis, and HCC), we identified a set of 19 candidate genes according to our algorithm of dynamic network biomarkers. These genes can both characterize different stages during HCC progression and identify cirrhosis as the critical transition stage before carcinogenesis. The interaction effects (i.e. coexpressions) of candidate genes were used to build an accurate prediction model: the so-called edge-based biomarker. Considering the convenience and robustness of biomarkers in clinical applications, we performed functional analysis, validated candidate genes in other independent samples of our collected cohort, and finally selected COL5A1, HLA-DQB1, MMP2, and CDK4 to build edge panel as prediction models. We demonstrated that the edge panel had great performance in both diagnosis and prognosis in terms of precision and specificity for HCC, especially for patients with alpha-fetoprotein-negative HCC. Our study not only provides a novel edge-based biomarker for non-invasive and effective diagnosis of HBV-associated HCC to each individual patient but also introduces a new way to integrate the interaction terms of individual molecules for clinical diagnosis and prognosis from the network and dynamics perspectives. | Yiyu Lu Zhaoyuan Fang Meiyi Li Chen Qian Tao Zeng Lina Lu Qilong Chen Hui Zhang Qianmei Zhou Yan Sun Xuefeng Xue Yiyang Hu Luonan Chen Shibing Su | 2019 | Journal of Molecular Cell Biology2019，11，8： | 3 |
| 3 | Therapeutic effect of Jianpi Liqi Fang(健脾理气方)combined with transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and spleen deficiency syndrome显示文摘OBJECTIVE:To investigate the therapeutic effect of the Jianpi Liqi Fang(健脾理气方,JPLQF)combined with transcatheter arterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC)and spleen deficiency syndrome(SDS)and identify a potential indicator of efficacy.METHODS:Ninety-nine patients with HCC who were diagnosed with SDS,non-spleen deficiency syndrome(NSDS),or no syndrome(NS)were treated with JPLQF combined with TACE for three periods.Therapeutic efficacy was compared among the groups.Plasma proteins were screened using label-free discovery analysis and verified via enzyme-linked immunosorbent assay(ELISA).Furthermore,receiver operating characteristic(ROC)curves were analyzed to evaluate therapeutic indicators.RESULTS:After treatment,the Karnofsky Performance Status was significantly improved in the SDS group and significantly better than that in the NS group.The Traditional Chinese Medicine(TCM)syndrome scores were lower in the SDS group after treatment and lower than those in the NSDS group.However,alanine aminotransferase,carbohydrate antigen 19-9,alpha-fetoprotein,and carcinoembryonic antigen levels and white blood cell and platelet counts did not differ among the groups.Serum aspartate aminotransferase levels in the SDS group were significantly lower after treatment than before treatment,and total bilirubin levels were significantly lower in the SDS group than in the NSDS group.Label-free analysis identified 24 differentially expressed proteins(DEPs)between the SDS and NS groups,including 17 and 7 upregulated and downregulated proteins,respectively.Fibulin-5(FBLN5)displayed the largest difference in expression between the groups.ELISA confirmed that FBLN5 levels were significantly lower in the NSDS and NS groups than in the SDS group.Following treatment with JPLQF and TACE,FBLN5 expression was upregulated only in the SDS group.Furthermore,ROC curve analysis indicated that FBLN5 may serve as a potential indicator of the efficacy of JPLQF combined with TACE in patients with HCC and SDS.CONCLUSION:JPLQF combined with TACE improved quality of life,clinical TCM symptoms,and liver function in patients with HCC and SDS.FBLN5 expression was significantly altered by treatment with JPLQF and TACE in patients with HCC and SDS. | CHEN Xiaole WANG Peng MENG Zhiqiang YANG Mengdie ZHOU Wenjun SU Shibing CHEN Jian | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 1 |
| 4 | Collective dynamics of small world networks 显示文摘 | Watts D J Su Shibing S H | 1998 | Nature1998，393，6684： | 1 |
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