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| 1 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 2 | The P,V,T,X properties of binary aqueous chloride solutions up to T = 573 K and 100 MPa显示文摘 | Mao Shide Duan Zhenhao | 2008 | Journal of Chemical Thermodynamics2008，40，7： | 1 |
| 3 | A thermodynamic model for calcula-ting methane solubility,density and gas phase composition of methane-bearing aqueous fluids from 273 to 523 K and from 1 to 2000 bar显示文摘 | Duan Zhenhao Mao Shide | 2006 | Geochimica et Cosmochimica Acta2006，70，13： | 1 |
| 4 | Applications of the IAPWS-95 formulation in fluid inclusion and mineral-fluid phase equilibria显示文摘在瓦格纳和 Pru (2002 ) 建议的 Helmholtz 免费精力明确的 IAPWS-95 明确的表达是水,所有热力学的性质能与试验性的精确性从 273.16 ~ 1273 K 并且从 0 ~ 1000 MPa 在一个宽 Tp 范围上从被获得的状态的最好的方程。这份报纸在液体包括和矿泉水阶段 equilibria 报导 IAPWS-95 明确的表达的应用。一个可靠、高度有效的计算方法为水的浸透的性质被介绍以便明确的表达能方便地在液体包括的学习被使用,例如精明的 homogenization 压力, homogenization 密度(或臼齿的体积) ,体积部分和 isochores。同时,一些矿物质脱水反应的 univariant 曲线基于 IAPWS-95 明确的表达被计算。IAPWS-95 明确的表达的计算机代码能从相应作者被获得。 | Lanlan Shi Shide Mao | 2012 | Geoscience Frontiers2012，3，1： | 1 |
| 5 | Thermodynamic modeling of binary CH4-H2O fluid inclusions显示文摘 | Mao Shide Duan Zhenhao Zhang Dehui | 2011 | Geochimica et Cosmochimica Acta2011，75，20： | 1 |
| 6 | A vapor-liquid phase equilibrium model for binary CO2-H2O and CH4-H2O systems above 523K for application to fluid inclusions显示文摘 | Mao Shide Duan Zhenhao Hu Wenxuan | 2009 | The Journal of Supercritical Fluids2009，50，1： | 1 |
| 7 | A model for single-phase PVTx properties of CO2-CH4-C2H6-N2-H2O-NaCl fluid mixtures from 273 to 1273 K and from 1 to 5000 bar显示文摘 | Mao Shide Duan Zhenhao Hu Jiawen | 2010 | Chemical Geology2010，275，34： | 1 |
| 8 | Applications of the SW96 formulation in the thermodynamic calculation of fluid inclusions and mineral-fluid equilibria显示文摘The SW96 formulation explicit in Helmholtz free energy proposed by Span and Wagner(1996)is the most accurate multifunction equation of state of CO_2 fluid,from which all thermodynamic properties can be obtained over a wide temperature-pressure range from 216.592 to 1100 K and from 0 to 8000 bar with or close to experimental accuracy.This paper reports the applications of the SW96 formulation in fluid inclusions and mineral-fluid equilibria.A reliable and highly efficient algorithm is presented for the saturated properties of CO_2 so that the formulation can be conveniently applied in the study of fluid inclusions,such as calculation of homogenization pressures,homogenization densities(or molar volumes),volume fractions of vapor phase and isochores.Meanwhile,the univariant curves of some typical decarbonation reactions of minerals are calculated with the SW96 formulation and relevant thermodynamic models of minerals.The computer code of the SW96 formulation can be obtained from the corresponding author. | Jia Zhang Shide Mao | 2017 | Geoscience Frontiers2017，8，6： | 1 |
| 9 | Thermodynamic modeling of binary CH4-H20 fluid inclusions显示文摘 | Mao shide | 2011 | Geochimica et Cosmochimica Acta2011，5，20： | 1 |
| 10 | A model for single-phase PVTx properties of CO2-CH4-C2H6-N2-H20-NaC1 fluid mixtures from 273 to 1273 K and from 1 to 5000 bar显示文摘 | Mao shide | 2010 | Chemical Geology2010，，275： | 1 |
| 11 | Extension of the IAPWS-95 formulation and an improved calculation approach for saturated properties显示文摘 | Mao shide | 2011 | Physics of the Earth and Planetary Interiors2011，，185： | 1 |
| 12 | The viscosity of aqueous alkali-chloride solutions up to 623 K, 1000 bar and high ionic strength显示文摘 | Mao shide | 2009 | International Journal of Thermophysics2009，，30： | 1 |
| 13 | A vapor-liquid phase equilibrium model for binary CO:H20 and CH4-H20 systems above 523 K for application to fluid inclusions显示文摘 | Mao shide | 2009 | The Journal of Supercritical fluids2009，，50： | 1 |
| 14 | Thermodynamic Modeling of Ternary CO_2-H_2O-NaCl Fluid Inclusions显示文摘Up to now,fluid inclusion is still a powerful tool to estimate the temperature and pressure of various geological processes.CO_2-bearing inclusions are commonly found in many environments.Among the CO_2-bearing inclusions,the most typical are the ternary CO_2-H_20-NaCl inclusions.These saltbearing CO_2 V-L inclusions at room temperatures are coexisting H_2O liquid +CO_2 liquid +CO_2 vapor or coexisting H_20 liquid +CO_2 liquid(or vapor).On heating they often finally homogenize to liquid phase by the bubble disappearance,and they may form CO_2 hydrate and ice during cooling.This paper reports the application of thermodynamic models,including equations of state,to ternary CO_2-H_20-NaCl fluid inclusions.Some simple equations for pressure-temperature-salinity relation on the CO_2 hydrate-liquid-vapor(liquid) surface are developed to calculate the NaCl contents(salinities) of inclusions.With these relations and the latest CO_2 solubility and PVTx models,a new iterative approach is presented to calculate the CO_2 contents of CO_2-H_20-NaCl inclusions on the assumption that the bulk molar volume of an inclusion keeps constant at the disappearances of CO_2 hydrate and vapor bubble.A prominent merit of this method is that the compositions,molar volumes and homogenization pressures of CO_2-H_20-NaCl inclusions can be simultaneously obtained without using experimental optical volume fractions of vapor bubbles at the dissociation temperatures of CO_2 hydrates.Meanwhile,the homogenization pressures and isochores of CO_2-H_2O-NaCl fluid inclusions from updated models are briefly discussed.Calculation program code for the ternary CO_2-H_2O-NaCl inclusions with microthermometric measurement and Raman analysis data as input variables can be obtained from the author. | Mao Shide Zhang Dehui | 2012 | 地球科学进展2012，27，S1： | 0 |
| 15 | Grafting of protein-protein binding sites显示文摘A strategy for grafting protein-protein binding sites is described. Firstly, key interactionresidues at the interface of ligand protein to be grafted are identified and suitable positions in scaffold protein for grafting these key residues are sought. Secondly, the scaffold proteins are superposed onto the ligand protein based on the corresponding Cα and Cβ atoms. The complementarity between the scaffold protein and the receptor protein is evaluated and only matches with high score are accepted. The relative position between scaffold and receptor proteins is adjusted so that the interface has a reasonable packing density. Then the scaffold protein is mutated to corresponding residues in ligand protein at each candidate position. And the residues having bad steric contacts with the receptor proteins, or buried charged residues not involved in the formation of any salt bridge are mutated. Finally, the mutated scaffold protein in complex with receptor protein is co-minimized by Charmm. In addition, we | Shide Liang Lan Xiao Fenglou Mao Lin Jiang Yuzhen Han Luhua Lai | 2000 | Chinese Science Bulletin2000，45，18： | 0 |
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