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| 1 | Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting显示文摘Glioblastomas(GBMs)are highly lethal primary brain tumors.Despite current therapeutic advances in other solid cancers,the treatment of these malignant gliomas remains essentially palliative.GBMs are extremely resistant to conventional radiation and chemotherapies.We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells(GSCs)promotes therapeutic resistance.We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth,which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs.Furthermore,stem cell-like cancer cells(cancer stem cells)have been shown to promote metastasis.Although GBMs rarely metastasize beyond the central nervous system,these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection,and GSCs display an aggressive invasive phenotype.These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment.Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells,but also display critical distinctions that provide important clues into useful therapeutic targets.In this review,we summarize the current understanding and advances in glioma stem cell research,and discuss potential targeting strategies for future development of anti-GSC therapies. | Zhi Huang Lin Cheng Olga A.Guryanova Qiulian Wu Shideng Bao | 2010 | Protein & Cell2010，1，7： | 18 |
| 2 | Long-term,multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production显示文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds. | Ziyao Fan Zhiguo Liu Kui Xu Tianwen Wu Jinxue Ruan Xinmin Zheng Shideng Bao Yulian Mu Tad Sonstegard Kui Li | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 3 | Elevated invasive potential of glioblastoma stem cells显示文摘 | Lin Cheng Qiulian Wu Olga A. Guryanova Zhi Huang Qian Huang Jeremy N. Rich Shideng Bao | 2011 | Biochemical and Biophysical Research Communications2011，，： | 1 |
| 4 | Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells显示文摘 | Zhizhong Li Shideng Bao Qiulian Wu | 2009 | Cancer Cell2009，15，： | 1 |
| 5 | Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor显示文摘 | Bao Shideng Bigner DD Rich JN | 2006 | Cancer Res2006，66，： | 1 |
| 6 | Glioma stem cells promote radioresistance by preferential activation of the DNA damage response显示文摘 | Bao Shideng Wu Qiulian Mclendon RE | 2006 | Nature2006，444，7120： | 1 |
| 7 | Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway显示文摘 | Shideng Bao Gaoliang Ouyang Xuefang Bai Zhi Huang Chaoyu Ma Ming Liu Rong Shao Ryan M Anderson Jeremy N Rich Xiao-Fan Wang | 2004 | Cancer Cell2004，，4： | 1 |
| 8 | Hydrogen peroxide-induced apoptosis in human gastric carcinoma MGC803 cells显示文摘 | Yubin Mao Gang Song Qiufeng Cai Min Liu Haohong Luo Mingxin Shi Gaoliang Ouyang Shideng Bao | 2006 | Cell Biology International2006，，4： | 1 |
| 9 | Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway显示文摘 | Shideng Bao Gaoliang Ouyang Xuefang Bai Zhi Huang Chaoyu Ma Ming Liu Rong Shao Ryan M Anderson Jeremy N Rich Xiao-Fan Wang | 2004 | Cancer Cell2004，，4： | 1 |
| 10 | The multifaceted role of periostin in tumorigenesis显示文摘 | Kai Ruan Shideng Bao Gaoliang Ouyang | 2009 | Cellular and Molecular Life Sciences2009，，14： | 1 |
| 11 | Potential therapeutic implications of cancer stem cells in glioblastoma 显示文摘 | Lin C Shideng B Jeremy NR | 2010 | Biochemical Pharmacology2010，80，5： | 1 |
| 12 | Atomistic Insights into Oxidation of Chemical Passivated Silicon(100)Surface:Reactive Molecular Dynamic Simulations显示文摘Main observation and conclusion In this paper,a series of ReaxFF molecular dynamic simulations were performed to study the oxidation of chemical passivated silicon(100)surface,which was terminated with different n-alkyl chains.The simulated results showed that the oxidant species diffuse into Si substrate through peroxy-like structures during the oxidation process.During the oxidation process,the Si-alkyl(Si-C)covalent bond was stable and there is no occurrence of decomposition of the n-alkyl chains.In addition,the existence of n-alkyl monolayers on silicon surface did not change the initial reaction pathway of the oxidation process.The simulations indicated that the chemical passivation mechanism includes two parts,one is about the Si-C covalent bond occupying the active site of the reaction on Si(100)surface,and the other is about the oxygen penetrating Si-alkyl layers.The simulations also indicated that the chemical passivation of Si-alkyl is better for longer alkyl chains,which is consistent with the experimental observation.Our results have investigated the oxidation of chemical passivated silicon(100)surface at the atom level,which is helpful to comprehend the manufacture of semiconductor devices like metal-oxide-semiconductor(MOS)devices in the experiments. | Shideng Yuan Xueyu Wang Heng Zhang Shiling Yuan | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
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