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803篇 您的检索式：作者名="Shields J"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	爱尔兰海洋经济和资源显示文摘什么是爱尔兰? 这或许是个奇怪的问题。目前还很少有人认为爱尔兰是一个海洋国家。如果有人认为爱尔兰由9万平方公里的陆域面积和90万平方公里的海域面积组成,就更加稀奇了。	Y Shields J O’Cornor J O’Leary 周怡圃王占坤羊志洪	2010	经济资料译丛2010，，1：	4
3	Global burden of alcoholic liver diseases<!-- Doctopic: Review -->显示文摘	Jürgen Rehm Andriy V. Samokhvalov Kevin D. Shield	2013	Journal of Hepatology2013，，1：	2
4	A systematic review of the epidemiology of unrecorded alcohol consumption and the chemical composition of unrecorded alcohol显示文摘	Jürgen Rehm Shalini Kailasapillai Elisabeth Larsen Maximilien X. Rehm Andriy V. Samokhvalov Kevin D. Shield Michael Roerecke Dirk W. Lachenmeier	2014	Addiction2014，，6：	2
5	Global burden of alcoholic liver diseases显示文摘	Jürgen Rehm Andriy V. Samokhvalov Kevin D. Shield	2013	Journal of Hepatology2013，，1：	2
6	Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf -independent pathways显示文摘	Shields J M Rogers Graham K Der C J	2002	J Biol Chem2002，277，12：	1
7	Characterization of the interactions between MHC class I subunits: A systematic app roach for the engineering of higher affinity variants of beta 2-microglobulin显示文摘	Shields M J Assefi N Hodgson W	1998	Immunol1998，160，：	1
8	Sr,C,and O isotope geochemistry of Ordovician brachiopods:A major isotopic event around the Middle-Late Ordovician transition显示文摘	Shields G A Carden G A F Veizer J	2003	Geochimica et Cosmochimica Acta2003，67，11：	1
9	Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells显示文摘	Shields B Mills J Ghildyal R	2003	Arch Virol2003，148，10：	1
10	In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering显示文摘	Wayne J S McDowell C L Shields K J	2005	Tissue Eng2005，11，56：	1
11	An application of the hierarchicalapproach to fire safety 显示文摘	Shields J Silcock G	1986	Fire Safety Journal1986，，11：	1
12	Dustbathing by broiler chickens: A comparison of preference for four different substrates显示文摘	Shields S J J P Garner J A Meneh	2004	Appl Anim Behav Sci2004，87，：	1
13	Blastomere morphology as a predictive measure of fish eggviability显示文摘	Shields R J Brown N P Bromage N R	1997	Aquaculture1997，155，：	1
14	Comparisons among VOCs measured in three types of US commercial buildings with different occupant densities显示文摘	Shields H C Fleischer D M Weschler C J	1996	Indoor Air1996，6，1：	1
15	Family centred care for children in hospital 显示文摘	Shields L Pratt J Davis LM	2007	Cochrane Db Syst Rev2007，，00：	1
16	Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘	Shields C J Winter D C Redmond H P	2002	Curr Opin Crit Care2002，8，2：	1
17	H: sto- pathologic evideuce of fibrovascalar ingrowth four week after placemeut ofthe hydroxyapatite orbital implant显示文摘	Shields CL Shields J A Eagle Rc	1991	Am J ophthalmo1991，111，：	1
18	Partial lamellar sclerouvectomy for ciliary body and choroidal tumors显示文摘	SHIELDS J A SHIELDS C L SHAH P	1991	Ophthalmology1991，98，：	1
19	Pathology and hnaging of the Lacrimal Drainage System显示文摘	Ansari SA Pak J Shields M	2005	Neuroimaging Clin N Am2005，15，1：	1
20	CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses显示文摘	Calvert J G Slade D E Shields S L	2007	J Virol2007，81，14：	1

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