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| 1 | Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice显示文摘流行病的研究证明了女人们说明疾病(广告) 案例,在传播 gonadal 荷尔蒙的衰落为被认为是专业之一冒险的三分之二 Alzheimers 因素。另外,卵巢的荷尔蒙缺乏可以影响淀粉的(A) 免职,它与 autophagic 流动有一种靠近的关系。在这研究,我们在二个老鼠模型,上调查了短期或长期的卵巢的荷尔蒙剥夺的影响非转基因(野类型) 并且 APP/PS1 双 transgenic | Qiuhui Yao Min Feng Bo Yang Zhimin Long Shifang Luo Min Luo Guiqiong He Kejian Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 2 |
| 2 | Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice显示文摘-secretase 建筑群催化淀粉的蛋白质先锋应用软件的最后的劈开步产生淀粉的 A 肽,在 Alzheimer 的疾病广告病人的大脑的老年的匾的一个病原的部件。最近的研究显示出那 presenilin enhancer-2 1 是的 Pen-2, presenilin PS,包括的 PS1 和 PS2, nicastrin,和前面的咽有缺陷者 -secretase 的必要部件。在 vitro 的 Pen-2 的结构和功能是明确的。然而,很少在广告模型老鼠的中央神经系统 CNS 对 Pen-2 的神经解剖学的分发和表示被知道。我们这里报导,用象染色的 immunohistochemical 和 immunoblotting 那样的各种各样的方法,那 Pen-2 广泛地在广告模型老鼠在主要区域的特定的 neuronal 房间被表示包括嗅觉的灯泡,基础前脑, striatum ,外皮,马头鱼尾的怪兽,杏仁之类,丘脑,视下丘,小脑, brainstem ,并且针的绳索。它在老鼠大脑在特定的 neuronal 房间与 PS1 被共同表示。Pen-2 比细胞外的淀粉的存款广泛地更分布式,建议在局部性的淀粉的免职的另外的因素的重要性。Pen-2 在成年广告鼠标在房间膜和 cytoplasma 主要是局部性的,但是仅仅在控制在房间膜散布。在出生后的开发的早阶段, Pen-2 的表达式水平在 CNS 相对高,但是在成年鼠标逐渐地衰退。现在的学习作为一个关键部件为 Pen-2 提供一个解剖基础在发展和成年老鼠的大脑复杂的 -secretase,和 Pen-2 可能是仔细与在老化的负担有关神经系统。 | Yanan Chu Xuehua Peng Zhiming Long Kejian Wang Shifang Luo Akhilesh Sharma Guiqiong He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 1 |
| 3 | Aquaporin-4 in the formation of cerebral edema following severe burns What role do arginine vasopressin levels play?显示文摘BACKGROUND: Aquaporin-4 (AQP-4), which is able to rapidly transport water within the brain, is highly expressed in brain tissue. It also plays an important role in the formation of cerebral edema following brain injury. However, the role of AQP-4 in the formation of cerebral edema following severe burns remains unknown. OBJECTIVE: To study changes in AQP-4 protein and mRNA expression during formation of cerebral edema following severe burns, and to explore the correlation between AQP-4 protein and mRNA expression with plasma levels of arginine vasopressin (AVP). DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Research Center of Neuroscience, Chongqing Medical University from 2007 to 2008. MATERIALS: Biotin-labeled goat anti-rabbit antibody was provided by Beijing Zhongshan Biotechnology, China; in situ hybridization kit was provided by Wuhan Boster Biotechnology, China; rabbit anti-AQP-4 polyclonal antibody and horseradish peroxidase-labeled goat anti-rabbit IgG were provided by Chemicon, USA; AVP radioimmunoassay kit was provided by the Research Department of Neurobiology, the Second Military Medical University of Shanghai, China. METHODS: A total of 180 adult, healthy, Wistar rats were randomly assigned to control and burn groups with 30 rats in each group. The burn group was observed at five different time points: 2, 6, 12, 24, and 48 hours after burn. Hair on the mouse back was removed to expose skin on the back. After 1 day, skin with the hair removed was dipped into 100 °C water for 15 seconds to induce grade III burn injury that measures 30% of total burn surface area. MAIN OUTCOME MEASURES: Brain water content was measured using the dry-wet weight method. AQP-4 protein and mRNA expressions were detected using immunohistochemistry, in situ hybridization, Western blot, and reverse transcription-polymerase chain reaction; dynamic changes in plasma AVP were detected using radioimmunoassay. RESULTS: Brain water content gradually increased following severe burn injury. AQP-4 protein and mRNA expressions were upregulated in the supraoptic nucleus, suprachiasmatic nucleus, paraventricular nucleus, hippocampus, choroid plexus, and cerebral cortex. Plasma AVP levels increased following burn injury. AQP-4 protein and mRNA expressions positively correlated with brain water content and AVP levels during formation of cerebral edema (r = 0.870, 0.848, P < 0.01). CONCLUSION: AQP-4 participated in the formation of cerebral edema following burn injury. Plasma AVP upregulated AQP-4 expression in brain tissue, thereby promoting formation of cerebral edema. | Shifang Luo | 2010 | Neural Regeneration Research2010，5，7： | 1 |
| 4 | DNA barcoding reveals commercial fraud related to yak jerky sold in China显示文摘Dear Editor,Instances of food mislabeling and adulteration scandals focus public attention on food safety and market fraud.Such scandals force the authorities to enforce stringent regulations on food adulteration.The Chinese government and consumers are paying more attention to food resource quality and safety regulation than ever before.The growing food market requires food authenticity at all stages of | Yunyu Wang Kai He Long Fan Yushui Wang Shifang Wu Robert W Murphy Wenzhi Wang Yaping Zhang | 2016 | Science China(Life Sciences)2016，59，1： | 1 |
| 5 | Molecular Detection of TYLCV Isolates from Xinjiang Autonomous Region of China and Analysis of Its DNA-A Genome Sequences显示文摘In 2012,the symptoms of dwarf plants,yellowed and curled leaves were observed in tomato,pepper,eggplant,datura,poinsettia,florists cyclamen and anthurium in Kashi,Tulufan and Yili regions of Xinjiang autonomous region in China.The results showed that all of the above seven species of plants could be infected by Tomato yellow leaf curl virus(TYLCV).We obtained the full-length DNA-A genome sequences of the virus isolate that KSCTo4,KSCTo16, KZPTo18 and KYCTo20 from tomato,KSCPe6 and KSCPe7 from pepper,KSCEg1from eggplant and KSCDa from datura.Each isolate had all of the characteristic features of Begomovirus genome.Virus isolate collected from different hosts had little difference in sequence,and shared the similarity of 99.0%-99.8% with each other.These isolate shared the similarity of 98.6%-99.5% with TYLCV isolate SH3,ZJ6,SD2A-7,HNSQ and HBBD reported in China. | Ding Yingna Li Shifang Zhang Sheng Cui Yuanyu Yang Hua He Wei Sun Xiaojun | 2013 | Plant Diseases and Pests2013，4，6： | 1 |
| 6 | A classification method of building structures based on multi-feature fusion of UAV remote sensing images显示文摘In order to improve the accuracy of building structure identification using remote sensing images,a building structure classification method based on multi-feature fusion of UAV remote sensing image is proposed in this paper.Three identification approaches of remote sensing images are integrated in this method:object-oriented,texture feature,and digital elevation based on DSM and DEM.So RGB threshold classification method is used to classify the identification results.The accuracy of building structure classification based on each feature and the multi-feature fusion are compared and analyzed.The results show that the building structure classification method is feasible and can accurately identify the structures in large-area remote sensing images. | Haoguo Du Yanbo Cao Fanghao Zhang Jiangli Lv Shurong Deng Yongkun Lu Shifang He Yuanshuo Zhang Qinkun Yu | 2021 | Earthquake Research Advances2021，1，4： | 0 |
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