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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Oxidative stress and antioxidants in hepatic pathogenesis显示文摘Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches. | Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，48： | 18 |
| 3 | High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer显示文摘AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric cancer.METHODS:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric cancer.Of these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 preoperatively.For this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as controls.Statistically significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS software.RESULTS:The baseline characteristics showed some differences between the two groups with regard to histology.Overall survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate analysis.Also,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate analysis.Additionally,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)analyses.CONCLUSION:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer. | A Ra Choi Jun Chul Park Jie-Hyun Kim Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jae Bock Chung | 2013 | World Journal of Gastroenterology2013，19，32： | 8 |
| 4 | Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization显示文摘·AIM: To evaluate whether trapping vascular endothelial growth factor-A(VEGF-A) would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture model.·METHODS: We established two groups of animals, one with non-dry eyes and the other with induced dry eyes.In both groups, a corneal suture model was used to induce inflammation and neovascularization. Each of two groups was again divided into three subgroups according to the treatment; subgroup I(aflibercept),subgroup II(dexamethasone) and subgroup III(phosphate buffered saline, PBS). Corneas were harvested and immunohistochemical staining was performed to compare the extents of neovascularization and CD11b+ cell infiltration. Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and VEGF-A in the corneas.·RESULTS: Trapping VEGF-A with aflibercept resulted in significantly decreased angiogenesis and inflammation compared with the dexamethasone and PBS treatments in the dry eye corneas(all P <0.05), but with no such effects in non-dry eyes. The anti-inflammatory and antiangiogenic effects of VEGF-A trapping were stronger than those of dexamethasone in both dry eye and non-dry eye corneas(all P <0.05). The levels of RNA expression of VEGF-A, TNF-alpha, and IL-6 in the aflibercept subgroup were significantly decreasedcompared with those in the PBS subgroup in the dry eye group.·CONCLUSION: Compared with non-dry eye corneas,dry eye corneas have greater amounts of inflammation and neovascularization and also have a more robust response to anti-inflammatory and anti-angiogenic agents after ocular surface surgery. Trapping VEGF-A is effective in decreasing both angiogenesis and inflammation in dry eye corneas after ocular surface surgery. | Jin Woo Kwon Jin A Choi Eun Young Shin Tae Yoon La Dong Hyun Jee Yeon Woong Chung Yang Kyung Cho | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 5 |
| 5 | Confounding risk factors and preventative measures driving nephrolithiasis global makeup显示文摘Nephrolithiasis is increasing in developed and developing countries at an alarming rate. With the global spike in kidney stone diseases, it is crucial to determine what risk factors are influencing the current global landscape for kidney stones. Our aims for this review are: to identity and analyze the four categories of risk factors in contributing to the global scale of stone formation: lifestyle, genetics, diet, and environment; and discuss preventative measures for kidney stone formation. We also performed data search through the published scientific literature, i.e., PubMed~? and found that there is a significant link between lifestyle and obesity with cases of calcium stones. Food and Agriculture Organization of the United Nations and World Health Organization factor indicators for dietary intake and obesity, along with climate data were used to create the projected total risk world map model for nephrolithiasis risk. Complete global analyses of nephrolithiasis deplete of generalizations is nearly insurmountable due to limited sources of medical and demographic information, but we hope this review can provide further elucidation into confounding risk factors and preventative measures for global nephrolithiasis analysis. | Samuel Shin Aneil Srivastava Nazira A Alli Bidhan C Bandyopadhyay | 2018 | World Journal of Nephrology2018，7，7： | 4 |
| 6 | His-His-Leu,an angiotensinⅠconverting enzyme inhibitory peptide derived from Korean soybean paste,exerts antihypertensive activity in vivo显示文摘 | Shin Z I Yu R Park S A | 2001 | J Agric Food Chem2001，49，6： | 2 |
| 7 | Inflammation enhances epileptogenesis in the developing rat brain显示文摘 | Auvin S Mazarati A Shin D | 2010 | Neurobiol Dis2010，40，1： | 1 |
| 8 | Galactosylated chitosan-graft-dextran as hepatocyte-targeting DNA carrier 显示文摘 | Park Y K Park Y H Shin B A | 2000 | Journal of Controlled Release2000，69，： | 1 |
| 9 | Mammary presentation of adult-type 'juvenile' xanthogranuloma显示文摘 | Shin S J Scamman W Gopalan A | 2005 | Am J Surg Pathol2005，29，6： | 1 |
| 10 | Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species显示文摘 | Lee K Y·Chong H·B·Shin Y·A·Kim D·Yong and J·H·Yum | 2001 | Clin Microbiol Infect2001，7，： | 1 |
| 11 | A dominant negative cadherin inhibits osteoblast differrentiation 显示文摘 | Cheng S L Shin C S Towler D A | 2000 | J Bone Miner Res2000，15，12： | 1 |
| 12 | Current Status of Clinical Trials and GCP in the Republic of Korea显示文摘 | Shin S A | 1997 | Drug Information1997，，31： | 1 |
| 13 | CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea 显示文摘 | Gwack J Shin A Kim C | 2006 | Br J Cancer2006，95，5： | 1 |
| 14 | Detection of approximately 10( 3 ) copies of DNA by an electrochemical enzyme- amplified sandwich assay with ambient O (2)as the substrate显示文摘 | Zhang Y Pothukuchy A Shin W Kim Y and Heller A | 2004 | Analytical Chemistry2004，76，： | 1 |
| 15 | Cognitive Network Interference显示文摘 | RABBACHIN A QUEK T Q SHIN H | 2011 | IEEE Journal on Selected Areas in Communications2011，29，2： | 1 |
| 16 | Inflammation en- hances epileptogenesis in the developing rat brain显示文摘 | Auvin S Mazarati A Shin D | 2010 | Neurobiol Dis2010，40，1： | 1 |
| 17 | Efficient Reduction of Graphite Oxide by Sodium Borohydfide and Its Effect on Electrical Conductance 显示文摘 | Shin H J Sire K K Benayard A | 2009 | Advanced Functional Materials2009，19，12： | 1 |
| 18 | Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression显示文摘 | HELMRATH M A SHIN C E ERWIN C R | 1998 | Journal of Pediatric Surgery1998，33，7： | 1 |
| 19 | Testing for a unit root in the nonlinear STAR framework显示文摘 | Kapetanios G Shin Y Snell A | 2003 | Journal of Econometrics2003，112，2： | 1 |
| 20 | Association of colorectal adenoma with components of metabolic syndrome 显示文摘 | Kim BC Shin A Hong CW | 2012 | Cancer Causes Control2012，23，5： | 1 |
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