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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Combustion synthesis of Ce^(3+), Eu^(3+) and Dy^(3+) activated NaCaPO_4 phosphors显示文摘The preparation of NaCaPO4 doped with rare earth (RE) ions Ce3+, Eu3+ and Dy3+ by combustion method was described. Under UV excitation (251 nm) of NaCaPO4:Ce3+ showsd emission (367 nm) in UV range. When NaCaPO4:Dy3+ phosphor was excited at 349 nm, the emission spectrum showed intense bands at 482 nm (blue) and 576 nm (yellow). In Eu activated NaCaPO4 phosphor, the emission spectrum showed a dominant peak at 594 nm (orange) while others were at 614 and 621 nm (red) when excited at 393 nm. The prepared phosphor was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and photoluminescence (PL) measurement. Thus, the photoluminescence behavior of NaCaPO4:Ce3+ was strongly suggested for scintillator. Likewise, Eu3+ and Dy3+ activated NaCaPO4 phosphors were recommended for near-UV white light-emitting diodes (LEDs). | K N Shinde S J Dhoble Animesh Kumar | 2011 | Journal of Rare Earths2011，29，6： | 7 |
| 3 | Hybrid personalized recommender system using centering-bunching based clustering algorithm显示文摘 | Shinde S K Kulkarni U | 2012 | Expert Systems with Applications2012，39，1： | 1 |
| 4 | Improvement of the water purification capability of poly(acrylonitrile), ultrafiltration membranes显示文摘 | Shinde M H Kulkami S S Musale D A | 1999 | J Membr Sci1999，162，： | 1 |
| 5 | N-doped ZnO based fast response ultraviolet photoconductive detector 显示文摘 | Shind S S Bhosale C H | 2012 | Solid- State Electronics2012，68，： | 1 |
| 6 | Process intensification of immobilized lipase catalysis by microwave irradiation in the synthesis of 4-chloro-2- methylphenoxyacetic acid (MCPA) esters显示文摘 | Shinde S D Yadav G D | 2014 | Biochemical Engineering Journal2014，，： | 1 |
| 7 | Chemical synthesis of titania (TiO2) powder via mixed precursor route for membrane applications显示文摘 | PATIL A J SHINDE M H PPTDAR H S | 2001 | Mater Chem Phys2001，，68： | 1 |
| 8 | Development of CZTS thin films solar cells by pulsed laser deposition:influence of pulse repetition rate显示文摘 | MOHOLKAR A V SHINDE S S BABAR A R | | 0，，07： | 1 |
| 9 | Occurrence of 'J waves' in 12-lead ECG as a marker of acute ischemia and their cellular basis 显示文摘 | Hinde R Shinde S Makhale C | 2007 | Pacing Clin Electrophysio12007，30，6： | 1 |
| 10 | FPGA based packet splitter implementation using mixed design flow显示文摘 | Shinde S A Shelake V G Kamat R K | 2008 | Electronics and Electrical Engineering2008，8，88： | 1 |
| 11 | High thermal conductivity materials 显示文摘 | Watari K Shinde S L | 2001 | MRS Bulletin2001，26，6： | 1 |
| 12 | Design and evaluation of microemulsion gel system of nadifloxacin 显示文摘 | SHINDE U POKHARKAR S MODANI S | 2012 | Indian J Pharm Sci2012，74，3： | 1 |
| 13 | Hydrophobic and textured ZnO films deposited by chemical bath deposition:annealing effect显示文摘 | Shinde V R Lokhande C D Mane R S Han S H | 2005 | Appl Surf Sci2005，245，： | 1 |
| 14 | A Simulation Model for Fate and Transport of Methyl Bromide during Fumigation in Plastic-mulched Vegetable Soil Beds显示文摘 | SHINDE D HORNSBY A G MANSELL R S | 2000 | Pest Manag Sci2000，56，10： | 1 |
| 15 | A novel zinc bis (thiosemicarbazone) complex for live cell imaging 显示文摘 | DAYAL D PALANIMUTHU D SHINDE S V | 2011 | J Biol Inorg Chem2011，16，4： | 1 |
| 16 | Hall effect in cobalt-doped TiO2_ 显示文摘 | Higgins J S Shinde S R Ogale S B | 2004 | Phys Rev B2004，69，07： | 1 |
| 17 | Review of clinical and laboratory features of human brucellosis 显示文摘 | Mantur B G Amarnath S K Shinde R S | 2007 | Indian J Med Microbiol2007，25，3： | 1 |
| 18 | Corrosion protective poly(o-toluidine) coatings on copper 显示文摘 | Shinde V Sainkar S Patil P | 2005 | Corros Sci2005，47，6： | 1 |
| 19 | Physical Properties of Transparent and Conducting Sprayed Fluorine Doped Zinc Oxide Thin Films显示文摘 | Shinde S S Shine P S Pawar S M | 2008 | Solid State Sciences2008，10，1： | 1 |
| 20 | A Nu-merical Model to Obtain Temperature Distribution DuringHard Turning of AISI 52100 Steel显示文摘 | BAPAT P S DHIKALE P D SHINDE S M | 2015 | Materials Today:Proceedings2015，2，4： | 1 |
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