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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Supercapacitor characteristic of La-doped Ni(OH)_2 prepared by electrodeposition显示文摘Samples of lanthanum-doped nickel hydroxide were prepared by electrodeposition method. The structure and electrochemical properties of the samples were studied by X-ray diffraction and a home-made open three-electrode cell system,respectively. The results show that the deposition process of Ni(OH)2 and La(OH)3 is mainly controlled by electrochemical polarization,which makes it easy to form uniform fine crystals. In addition,La(OH)3 is not a separate phase and lanthanum ions are doped into Ni(OH)2 crystal lattices. When V(0.5 mol/L Ni(NO3)2)/V(0.25 mol/L La(NO3)3) was 9:1,the lanthanum-doped nickel hydroxide reached the highest discharge capability of 840 F/g with a good cyclic reversibility. The capability still retains 670 F/g when the discharge current reaches 1000 mA/g. | Shao Guangjie Yao Yue Zhang Shipin He Pei | 2009 | Rare Metals2009，28，2： | 2 |
| 3 | Physiological and quality responses of longan fruit to high O2 or CO2 atmosphere in storage 显示文摘 | Shipin Tian | 2002 | Postharvest Biology and Technology2002，24，： | 1 |
| 4 | Integrated natural treatment systems for developing communities: low-tech N- removal through the fluctuating microbial pathways显示文摘 | Shipin O Koottatep T Khanh N T T | 2005 | Water Science & Technology2005，51，12： | 1 |
| 5 | Physiological and quality responses of longan fruit to high O2 or CO2 atmosphere in storage显示文摘 | Shipin Tian | 2002 | Postharvest Biology and Technology2002，24，： | 1 |
| 6 | Analysis of critical paths in a project network with fuzzy activity times显示文摘 | Chen Shipin | 2007 | European Journal of Operational Research2007，183，1： | 1 |
| 7 | Analysis of critical paths in a project network with fuzzy activity times显示文摘 | Chen Shipin | 2007 | European Journal of Operational Research2007，183，1： | 1 |
| 8 | Effect of salinityon adsorption and desorption of paraquat in Pak phanang riversediment,Thailand显示文摘 | Noicharoen D Parkpian P Shipin OV | 2012 | J Environ Sci Health A Tox HazardSubst Environ Eng2012，47，12： | 1 |
| 9 | Zinc oxide nanorod mediated visible light photoinactivation of model microbes in water显示文摘 | Sapkota A Anceno AJ Baruah S Shipin OV Dutta J | 2011 | Nanotechnology2011，22，21： | 1 |
| 10 | Integrated natural treatment systems for developing communities: Low-tech N-removal through the fluctuating microbial pathways显示文摘 | Shipin O Koottatep T Khanh N T T | 2005 | Water Science and Technology2005，51，12： | 1 |
| 11 | Effect of salinity on adsorption and desorption of paraquat in pak phanang river sediment, thailand 显示文摘 | NOICHAROEN D PARKPIAN P SHIPIN O V | 2011 | Journal of Enviornmental Science and Health Part a-Toxic/Hazadous Substances & Environmental Engineering2011，47，12： | 1 |
| 12 | Hybrid artificial bee colony algorithm for parameter estimation of proton exchange membrane fuel cell显示文摘 | Wei Zhang Ning Wang Shipin Yang | 2013 | International Journal of Hydrogen Energy2013，，14： | 1 |
| 13 | Ssoil-quality indicators for predicting sustainable organic rice production 显示文摘 | THUITHAISONG C PARKPIAN P SHIPIN O V | 2011 | Communications in Soil Science and Plant Analysis2011，42，5： | 1 |
| 14 | Effect of salinity on adsorption and desorption of paraquat in Pak Phanang river sediment,Thailand显示文摘 | Noicharoen D Parkpian P Shipin O.V | | 0，，： | 1 |
| 15 | Simultaneous removal of nickel and zinc from aqueous solution by micellar-enhanced ultrafiltration and activated carbon fiber hybrid process显示文摘 | Bundit Channarong Seung Hwan Lee Rabindra Bade Oleg V. Shipin | 2010 | Desalination2010，，1： | 1 |
| 16 | The 2004 tsunami in Aceh and Southern Thailand: A review on coastal ecosystems, wave hazards and vulnerability显示文摘 | Roland Cochard Senaratne L. Ranamukhaarachchi Ganesh P. Shivakoti Oleg V. Shipin Peter J. Edwards Klaus T. Seeland | 2007 | Perspectives in Plant Ecology Evolution and Systematics2007，，1： | 1 |
| 17 | Physiological and quality responses of longan fruit to high O2 or CO2 atmosphere in storage 显示文摘 | Shipin Tian | 2002 | Postharvest Biology and Technology2002，24，： | 1 |
| 18 | Effects of chitosan on control of postharvest diseases and physiological responses of tomato fruit显示文摘 | LIU Jia TIAN Shipin MENG Xianghong | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 19 | Effect of salinity on adsorption and desorption of paraquat in Pak phanang river sediment, thailand 显示文摘 | Noicharoen D Parkpian P Shipin 0 V | 2012 | J Environ Sci Health A Tox Hazard Subst Environ Eng2012，47，12： | 1 |
| 20 | Expression of co-stimulatory molecules B7-2 and PD-L1 on peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection显示文摘Objective:To explore the roles of the expression of the co-stimulatory molecule,B7-2,and the co-inhibitory molecule,PD-L1,on peripheral blood mononuclear cells in the mechanism of immunotolerance in chronic hepatitis B virus infection.Methods:Thirty HBV infected patients in the immunoreactive phase and 20 patients in the immunotolerant phase were enrolled in the study,while 20 healthy volunteers were used as controls.RT-PCR and real-time PCR methods were used to detect the expression levels of B7-2 and PD-L1 mRNA in peripheral blood mononuclear cells in chronic HBV infected patients.Results:The B7-2 expression in immunoreactive and immunotolerant patients was significantly lower than that in the controls(P all < 0.01);B7-2 expression in immunoreactive patients was significantly lower than in immunotolerant patients(P < 0.01).PD-L1 expression in immunoreactive patients and immunotolerant patients was significantly higher than that in normal controls(P all < 0.01).The PD-L1/B7-2 ratios in immunoreactive and immunotolerant patients were significantly higher than that of the healthy controls(P all < 0.01);the PD-L1/B7-2 ratio was significantly higher in the immunoreactive patients than in the immunotolerant patients(P < 0.01).Conclusion:In chronic HBV infection,changes in the expression of co-stimulatory and co-inhibitory molecules imply a protective adjustment against the patient's immune response that may result in increased immunotolerance and persistent HBV infection. | Lingxia Fei Shipin Wu Hongtao Chen | 2009 | Journal of Nanjing Medical University2009，23，5： | 0 |
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