|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current clinical management of gastrointestinal stromal tumor显示文摘Gastrointestinal stromal tumors(GISTs) are the most common malignant subepithelial lesions(SELs) of the gastrointestinal tract. They originate from the interstitial cells of Cajal located within the muscle layer and are characterized by over-expression of the tyrosine kinase receptor KIT. Pathologically, diagnosis of a GIST relies on morphology and immunohistochemistry [KIT and/or discovered on gastrointestinal stromal tumor 1(DOG1) is generally positive]. The prognosis of this disease is associated with the tumor size and mitotic index. The standard treatment of a GIST without metastasis is surgical resection. A GIST with metastasis is usually only treated by tyrosine kinase inhibitors without radical cure; thus, early diagnosis is the only way to improve its prognosis. However, a GIST is usually detected as a SEL during endoscopy, and many benign and malignant conditions may manifest as SELs. Conventional endoscopic biopsy is difficult for tumors without ulceration. Most SELs have therefore been managed without a histological diagnosis. However, a favorable prognosis of a GIST is associated with early histological diagnosis and R0 resection. Endoscopic ultrasonography(EUS) and EUS-guided fine needle aspiration(EUSFNA) are critical for an accurate diagnosis of SELs. EUSFNA is safe and effective in enabling an early histological diagnosis and adequate treatment. This review outlines the current evidence for the diagnosis and management of GISTs, with an emphasis on early management of small SELs. | Kazuya Akahoshi Masafumi Oya Tadashi Koga Yuki Shiratsuchi | 2018 | World Journal of Gastroenterology2018，24，26： | 70 |
| 2 | Clinical outcomes of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer显示文摘AIM To evaluate the clinical outcome of endoscopic submucosal dissection using the Clutch Cutter(ESDCC) in older patients. METHODS We reviewed 232 consecutive patients with early gastric cancer who underwent ESDCC between June 2010 and February 2014 at Aso Iizuka Hospital. We divided patients into two groups according to age: Older patients(> 80 years, n = 64) and non-older patients(≤ 80 years, n = 168). We retrospectively compared the prevalence rates of pre-existing comorbidities, anticoagulant therapy, en bloc resection, mean duration of hospitalization, incidence of ESDCC-related complications, change in performance status(PS) before and after ESDCC, and financial cost of admission. RESULTS The older group comprised 64 patients with a mean age of 84.1 years, and the non-older group comprised 168 patients with a mean age of 69.5 years. Older patients had significantly more pre-existing comorbidities than did non-older patients, specifically heart disease(P < 0.05). The en bloc resection rate in non-older patients was significantly higher than that in older patients(100% vs 95.3%, P = 0.02). There were no significant differences between the older and non-older groups in the incidence of ESDCC-related complications(i.e., postoperative bleeding and perforation) and the post-ESDCC change in PS. There were also no significant differences between the older and non-older groups in the mean duration of hospitalization(11.4 and 10.7 d, respectively) and financial cost of admission(657040 JPY and 574890 JPY, respectively).CONCLUSION ESDCC has a good clinical outcome in older patients. | Yoshihiro Otsuka Kazuya Akahoshi Kayoko Yasunaga Masaru Kubokawa Junya Gibo Shigeki Osada Kayo Tokumaru Kazuaki Miyamoto Takao Sato Yuki Shiratsuchi Masafumi Oya Hidenobu Koga Eikichi Ihara Kazuhiko Nakamura | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 3 | TLR2-mediated sur- vival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity 显示文摘 | Watanabe I Ichiki M Shiratsuchi A | 2007 | J Immunol2007，178，8： | 1 |
| 4 | Cathodic performance of LiMnl-xMxPO4 (M=Ti, Mg and Zr) annealed in an inert atmosphere 显示文摘 | SHIRATSUCHI T OKADA S DOI T JAMAKI J | 2009 | Electroehia Acta2009，54，11： | 1 |
| 5 | GML sensitizes cancer cells to Taxol by induction of apoptosis显示文摘 | r Kimura Y Furuhata T Shiratsuchi T et aI | 1997 | Oncogene1997，5，11： | 1 |
| 6 | TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity显示文摘 | Watanabe I Ichiki M Shiratsuchi A | 2007 | J Immunol2007，178，8： | 1 |
| 7 | Identification and sensory characterization of volatile flavor compounds in sesame seed oil显示文摘 | SHIMODA M SHIRATSUCHI H OSAJIMA Y etal | 1996 | Journal of Agricultural and Food Chemistry1996，44，12： | 1 |
| 8 | Extraskeleteral myxiod chondrosarcoma with rhabdoid features,with special reference to its aggressive behavior显示文摘 | Oshiro Y Shiratsuchi H Tamiya S | 2000 | Int J Surg Pathol2000，8，2： | 1 |
| 9 | Molecular cloning,mapping, and charctenzation of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1 显示文摘 | Futamura M Nishimori H Shiratsuchi T | 1999 | J Hum Genet1999，44，1： | 1 |
| 10 | Comparison of the odor concentrates by SDE and absorptive column method from green tea infusion显示文摘 | Shimoda M Shigematsu H Shiratsuchi H | 1995 | Agriculture and Food Chemistry1995，43，： | 1 |
| 11 | Dye-sensitized solid-state solar cells:Use of crystal growth inhibitors for deposition of the hole collector显示文摘 | Kumara G R A Konno A Shiratsuchi K | 2002 | Chem Mater2002，14，3： | 1 |
| 12 | Isolation and identification of volatile flavor compounds in non-fermented coarse- cut sausage显示文摘 | SHIRATSUCHI H SHIMODA M OSAJIMA Y | 1993 | Journal of Agricultural and Food Chemistry1993，41，4： | 1 |
| 13 | Volatile flavor compounds in spray-dried skim milk powder显示文摘 | SHIRATSUCHI H SHIMODA M IMAYOSHI K | 1994 | J Agric Food Chem1994，2，： | 1 |
| 14 | Volatile flavor compounds in spray-dried skim milk powder 显示文摘 | Shiratsuchi H Shimoda M Imayoshi K | 1994 | Journal of Agriculture and Food Chemistry1994，2，： | 1 |
| 15 | TLR2-mediated survival of Staphylococcus aureus in macrophages , a novel bacterial strategy against host innate immunity 显示文摘 | Watanabe I Ichiki M Shiratsuchi A | 2007 | J Immunol2007，178，8： | 1 |
| 16 | Histamine H2-receptor antagonistic action of N-{3-propylfacetoxy actamindehydrochloride显示文摘 | Tarutani M Sakuma H Shiratsuchi K | 1985 | Arzneimforschung1985，35，4： | 1 |
| 17 | Identification and sensory characterization of volatile flavor compounds in sesame seed oil显示文摘 | Shimoda M Shiratsuchi H Nakada Y | 1996 | Journal of Agricultural and Food Chemistry1996，44，12： | 1 |
| 18 | Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/ lysosomes in macrophages 显示文摘 | Shiratsuchi A Watanabe I Takeuchi O | 2004 | J Immunol2004，172，4： | 1 |
| 19 | Comparison of the odor concentrates by SDE and adsorptive column method from green tea infusion 显示文摘 | SHIMODA M SHIGEMATSU H SHIRATSUCHI H | 1995 | Journal of Agricultural and Food Chemistry1995，43，6： | 1 |
| 20 | Cathodic performance of LiMnl-:M:PO4 (M= Ti, Mg and Zr) annealed in an inert at- mosphere显示文摘 | Shiratsuchi T Okada S Doi T | 2009 | Electrochim Acta2009，54，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员