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| 1 | Evaluation of chitosaneanionic polymers based tablets for extended-release of highly watersoluble drugs显示文摘The objective of this study is to develop chitosaneanionic polymers based extendedrelease tablets and test the feasibility of using this system for the sustained release of highly water-soluble drugs with high drug loading.Here,the combination of sodium valproate(VPS)and valproic acid(VPA)were chosen as the model drugs.Anionic polymers studied include xanthan gum(XG),carrageenan(CG),sodium carboxymethyl cellulose(CMC-Na)and sodium alginate(SA).The tablets were prepared by wet granulation method.In vitro drug release was carried out under simulated gastrointestinal condition.Drug release mechanism was studied.Compared with single polymers,chitosaneanionic polymers based system caused a further slowdown of drug release rate.Among them,CS exanthan gum matrix system exhibited the best extended-release behavior and could extend drug release for up to 24 h.Differential scanning calorimetry(DSC)and Fourier transform infrared spectroscopy(FTIR)studies demonstrated that polyelectrolyte complexes(PECs)were formed on the tablet surface,which played an important role on retarding erosion and swelling of the matrix in the later stage.In conclusion,this study demonstrated that it is possible to develop highly water-soluble drugs loaded extendedrelease tablets using chitosaneanionic polymers based system. | Yang Shao Liang Li Xiangqin Gu Linlin Wang Shirui Mao | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，1： | 2 |
| 2 | A review on COVID-19 transmission,epidemiological features,prevention and vaccination显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused hundreds of millions of infections and millions of deaths over past two years.Currently,many countries have still not been able to take the pandemic under control.In this review,we systematically summarized what we have done to mitigate the COVID-19 pandemic,from the perspectives of virus transmission,public health control measures,to the development and vaccination of COVID-19 vaccines.As a virus most likely coming from bats,the SARS-CoV-2 may transmit among people via airborne,faecal-oral,vertical or foodborne routes.Ourmeta-analysis suggested that the R0 of COVID-19 was 2.9(95%CI:2.7–3.1),and the estimates in Africa and Europe could be higher.The median Rt could decrease by 23–96%following the nonpharmacological interventions,including lockdown,isolation,social distance,and face mask,etc.Comprehensive intervention and lockdown were the most effective measures to control the pandemic.According to the pooled R0 in our meta-analysis,there should be at least 93.3%(95%CI:89.9–96.2%)people being vaccinated around the world.Limited amount of vaccines and the inequity issues in vaccine allocation call for more international cooperation to achieve the antiepidemic goals and vaccination fairness. | Yuqin Zhang Gonghua Wu Shirui Chen Xu Ju Wumitijiang Yimaer Wangjian Zhang Shao Lin Yuantao Hao Jing Gu Jinghua Li | 2022 | Medical Review2022，2，1： | 2 |
| 3 | Lower Limb Muscle Forces in Table Tennis Footwork during Topspin Forehand Stroke Based on the OpenSim Musculoskeletal Model:A Pilot Study显示文摘Introduction:Footwork is one of the training contents that table tennis players and coaches focus on.This study aimed to gain a thorough understanding of the muscle activity of the table tennis footwork and creating a musculoskeletal model to investigate the muscle forces,joint kinematic,and joint kinetic characteristics of the footwork during topspin forehand stroke.Methods:Six male table tennis athletes(height:171.98±4.97 cm;weight:68.77±7.86 kg;experience:10.67±1.86 years;age:22.50±1.64 years)performed chasse step and one-step footwork to return the ball from the coach by topspin forehand stroke.The kinematics,kinetics,and muscle activity of the lower limb were recorded by the motion capture,force platform,and Electromyography(EMG)system.Statistical parametric mapping(SPM)analysis was used to investigate any difference between the chasse step and one-step footwork during the stroke.Results and Conclusion:The muscle force of the biceps femoris long head(p<0.001),lateral gastrocnemius(p<0.001),vastus lateralis(p<0.001),vastus medial(p<0.001),rectus femoris(p<0.001),and tibia anterior(p<0.001)of the chasse step were significantly greater than the one-step footwork during the early stroke phase(stance).At the end of the stroke phase(push-off),the muscle force of the biceps femoris long head(p<0.001),medial gastrocnemius(p<0.001),lateral gastrocnemius(p<0.001),rectus femoris(p<0.001),and tibias anterior(p<0.001)in the chasse step footwork was significantly greater than the one-step footwork.The muscle force of the ankle plantar flexor and valgus muscle groups in the one-step was significantly greater than in the chasse step.Besides,the moment and angle of hip flexion(p=0.001)and axial rotation(p=0.009)were significantly greater for the chasse step than the one-step footwork,as well as the ankle plantarflexion angle(p<0.001)and moment(p<0.001)of the one-step footwork were significantly higher than the chasse step footwork.The results of this study can be applied to movement control and injury prevention in table tennis footwork. | Yuqi He Shirui Shao Gusztáv Fekete Xiaoyi Yang Xuanzhen Cen Yang Song Dong Sun Yaodong Gu | 2022 | Molecular & Cellular Biomechanics2022，19，4： | 0 |
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