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23篇 您的检索式:作者名="Shivalila"
    题名 作者 年代 出处 被引量
1Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch 2013Cell Research2013,23,10:65
2One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering显示文摘Haoyi Wang Hui Yang Chikdu S. Shivalila Meelad M. Dawlaty Albert W. Cheng Feng Zhang Rudolf Jaenisch 2013Cell2013,,4:5
3One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering显示文摘Hui Yang Haoyi Wang Chikdu S. Shivalila Albert W. Cheng Linyu Shi Rudolf Jaenisch 2013Cell2013,,6:1
4One-step genera- tion of mice carrying reporter, conditional alleles by CRISPR/Cas-mediated genome engineering 显示文摘Yang H Wang H Shivalila C S 2013Cell2013,154,6:1
5One- step generation of mice carrying mutations in multi- ple genes by CRISPR/Cas-mediated genome engi- neering显示文摘WANG H YANG H SHIVALILA C S 2013Cell2013,153,4:1
6One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas- mediated genome engineering 显示文摘Wang H Yang H Shivalila CS 2013Cell2013,153,4:1
7One-step generation of mice carrying reporter and conditional al- leles by CRISPR/Cas-mediated genome engineering 显示文摘YANG H WANG H SHIVALILA C S 2013Cell2013,154,:1
8One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering 显示文摘WANG H YANG H SHIVALILA C S 2013Cell2013,153,4:1
9One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering 显示文摘WANG HY YANG H SHIVALILA CS 2013Cell2013,153,4:1
10One step generation of mice carrying mutations in multiple genes by CRISPR/Cas media- ted genome engineering显示文摘Wang H Yang H Shivalila CS 2013Ce112013,153,4:1
11One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas- mediated genome engineering 显示文摘Wang H Yang H Shivalila CS 2013Cell2013,153,4:1
12One-step generation ofmice carrying mutations in mu ltiple genes by CRISPR/Cas - me-diated genome engineering显示文摘Wang H Yang H Shivalila C S 2013Cell2013,153,:1
13One-step generation ofmice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering显示文摘Yang H Wang H Shivalila C S 2013Cell2013,154,:1
14One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering显示文摘Haoyi Wang Hui Yang Chikdu S. Shivalila Meelad M. Dawlaty Albert W. Cheng Feng Zhang Rudolf Jaenisch 2013Cell2013,,4:1
15One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas- mediated genome engineering显示文摘Wang H Yang H Shivalila C S 2013Cell2013,153,:1
16One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas- mediated genome engineering 显示文摘Yang H Wang H Shivalila CS 2013Cell2013,154,6:1
17One-step genera- tion of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering 显示文摘Wang H Yang H Shivalila C S 2013Cell2013,153,4:1
18One-step generation of micecarrying mutations in multiple genes by CRISPR/Cas-mediated ge-nome engineering显示文摘Wang H Yang H Shivalila CS 2013Cell2013,153,4:1
19One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering显示文摘Yang H Wang H Shivalila CS 2013Cell2013,154,6:1
20One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering显示文摘Wang H Yang H Shivalila CS 2013Cell2013,153,4:1
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