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| 1 | Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier显示文摘Androgen deprivation therapy(ADT)has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer(PCa).However,this approach is rarely curative.Recent clinical trials have demonstrated that ADT combined with other agents,notably docetaxel and abiraterone,lead to improved survival.The mechanisms surrounding this improved cancer outcomes are incompletely defined.The response of cancer cells to ADT includes apoptosis and cell death,but a significant fraction remains viable.Our laboratory has demonstrated both in vitro and in vivo that cellular senescence occurs in a subset of these cells.Cellular senescence is a phenotype characterized by cell cycle arrest,senescenceassociated b-galactosidase(SA-b-gal),and a hypermetabolic state.Positive features of cellular senescence include growth arrest and immune stimulation,although persistence may release cytokines and growth factors that are detrimental.Senescent tumor cells generate a catabolic state with increased glycolysis,protein turnover and other metabolic changes that represent targets for drugs,like metformin,to be applied in a synthetic lethal approach.This review examines the response to ADT and the putative role of cellular senescence as a biomarker and therapeutic target in this context. | Tyler Etheridge Shivashankar Damodaran Adam Schultz Kyle A.Richards Joseph Gawdzik Bing Yang Vincent Cryns David F.Jarrard | 2019 | Asian Journal of Urology2019，6，1： | 3 |
| 2 | Thin Films of VO2 on Glass by Atomic Layer Deposition: Microstructure and Electrical Properties显示文摘 | Dagur P Mane A U Shivashankar S A | 2005 | Journal of Crystal Growth2005，275，1： | 1 |
| 3 | Thin Films of VOz on Glass by Atomic Layer Deposition: Microstructure and Elec- trical Properties 显示文摘 | Dagur P Mane A U Shivashankar S A | 2005 | Journal of Crystal Growth2005，275，1： | 1 |
| 4 | Wavelet based co-occurrence histogram features for texture classification with an application to script identification in a document image 显示文摘 | Hiremath P S Shivashankar S | 2008 | Pattern Recognition Letters2008，29，： | 1 |
| 5 | A Critical Review of Construction, Analysis and Behaviour of Stone Columns显示文摘 | M. R. Dheerendra Babu Sitaram Nayak R. Shivashankar | 2013 | Geotechnical and Geological Engineering2013，，1： | 1 |
| 6 | An unusual complication of treatment with orlistat 显示文摘 | KARAMADOUKIS L SHIVASHANKAR GH LUDEMAN L etal | 2009 | ClinNephrol2009，71，4： | 1 |
| 7 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 8 | Microstruc- ture and Properties of VO2 Thin Films Deposited by MOCVD from Vanadyl Acetylacetonate 显示文摘 | Sahana M B Dharmaprakash M S Shivashankar S A | 2002 | Journal of Materials Chemistry2002，12，2： | 1 |
| 9 | Interaction behavior of steel grid reinforcements in clayey sand显示文摘 | Bergado D T Shivashankar R Alfaro M C | 1993 | Geotechnique1993，43，4： | 1 |
| 10 | Bonding residual stresses in high-temperature composites 显示文摘 | Dadras P Shivashankar S | 1996 | Comput Struct1996，59，3： | 1 |
| 11 | Effective length scale for predicting solvent-debinding times of components produced by powder injection molding显示文摘 | Shivashankar T S German R M | 1999 | Journal of the American Ceramic Society1999，82，5： | 1 |
| 12 | Thin Films of VO2 on Glass by Atomic Layer Deposition: Microstructure and Electrical Properties 显示文摘 | Pritesh Dagur Anil U Mane Shivashankar S A | 2005 | Journal of Crystal Growth2005，275，： | 1 |
| 13 | YAP/TAZ as mechanosensors and mechanotrans- ducers in regulating organ size and tumor growth显示文摘 | LOW B C PAN C Q SHIVASHANKAR G V | 2014 | FEBS Lett2014，588，： | 1 |
| 14 | Low- temperature electronic properties of a normal conducting perovskite oxide (LaNiO3)显示文摘 | Shivashankar G V Raychaudhuri A K | 1991 | Solid State Commun1991，79，： | 1 |
| 15 | Low pressure MOCVD of Er2O3 and Gd2O3 films 显示文摘 | Singh M P Shripathi T Shalini K Shivashankar S A | 2007 | Materials Chemistry and Physics2007，105，： | 1 |
| 16 | Effective length scale for predicting solvent-debinding times of components produced by powder injection molding显示文摘 | Shivashankar T S German R M | 1999 | Journal of the American Ceramic Society1999，82，5： | 1 |
| 17 | Wavelet based co-occurrence histogram features for texture classification with an application to script identification in a document image显示文摘 | Hiremath P S Shivashankar S | | 0，，09： | 1 |
| 18 | Structural and electrical characterization of erbium oxide films grown on Si (100)by low-pressure metal organic chemical vapor deposition 显示文摘 | Singh M P Thakur C S Shalini K Bhat N Shivashankar S A | 2003 | Applied Physics Letters2003，83，： | 1 |
| 19 | MOCVD of cobalt oxide thin films: dependence of growth, microstructure, and optical properties on the source of oxidation显示文摘 | Mane Anil U Shivashankar S A | 2003 | Crystal Growth2003，254，： | 1 |
| 20 | Master debinding curves for solvent extraction of binders in powder injection molding 显示文摘 | Enneti R K Shivashankar T S Park S J | 2012 | Powder Technology2012，228，： | 1 |
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