维普期刊资源整合服务平台（V6.5）

393篇 您的检索式：作者名="Shoemaker J"

选中清除导出查看参考文献查看引证文献引用追踪共20页首页上一页第1页下一页末页 /20 跳转

	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	An investigation of the chemical stability of arsenosugar in simulated gastric juice and acidic environments using IC-ICP-MS and IC-ESIMS/MS显示文摘	GAMBLE B M GALLAGHER P A SHOEMAKER J A	2002	Analyst2002，127，：	1
3	A new integrated genetic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretial and Applied Genetics2004，109，：	1
4	Loyalty:A strategic commitment显示文摘	Bowen J T Shoemaker S	1998	Cornell Ho- tel and Restaurant Administration Quarterly1998，39，1：	1
5	Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland 显示文摘	MAGA E A SHOEMAKER C F ROWE J D	2006	Journal of Dairy Science2006，89，2：	1
6	Design and testing of PCR primers for the construction of scFv libraries representing the immunoglobulin repertoire of rats显示文摘	Sepulveda J Shoemaker C B	2008	J Immunol Methods2008，332，12：	1
7	A new integrated ge-netic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and Applied Ge-netics2004，109，：	1
8	Journal of Microbiological Methods显示文摘	Donohue M J Smallwood A W Pfaller S Rodgers M Shoemaker J A	2006	65 : 3802006，65，：	1
9	Cytotoxic geranyl stilbenes from Macaranga schwein furthii显示文摘	BEUTLER J A SHOEMAKE R H TANYA JOHNSON	1998	J Nat Prod1998，61，12：	1
10	Lunar surface topography显示文摘	Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A	1966	Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，：	1
11	Reduced startle gating after D1 blockade: effects of concurrent D2 blockade 显示文摘	Swerdlow NR Shoemaker JM Bongiovanni M J	2005	Pharmacd Biochem Behav2005，82，2：	1
12	Strategic assets and or- ganizational rent 显示文摘	AMIT R SHOEMAKER P J H	1993	Strategic Management Journal1993，14，1：	1
13	Efficacy of Strepto~occus agalactiae ( group B ) vaccine in tilapia ( Oreochromis nilotlcus) by intraperitoneal and bath immersion administration 显示文摘	Evans J J Klesius P H Shoemaker C A	2004	Vaccine2004，22，2728：	1
14	Integration of simple sequence repeat DNA markers into a soybean linkage map 显示文摘	Akkaya M S Shoemaker R C Specht J E	1995	Crop Sci1995，35，5：	1
15	ABT-263:A Potent and orally bioavailable Bcl-2 family inhibitor显示文摘	Tse C Shoemaker AR Adickes J	2008	Cancer Research2008，68，9：	1
16	Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts 显示文摘	Boyle JP Wu X J Shoemaker CB	2003	Mol Bioehem Parasitol2003，128，2：	1
17	Phylogenetic Utility of Histone H3 Intron Sequences in the Perennial Relatives of Soybean(Glycine:Leguminosae)显示文摘	Doyle J J Kanazin V Shoemaker R C	1996	Mol Phylogenet Evol1996，6，：	1
18	The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal eompartments显示文摘	Offe K Dodson S E Shoemaker J T	2006	J Neurosei2006，26，5：	1
19	Observations of the lunar regolith and the Earth from the television camera on Surveyor 7显示文摘	Shoemaker E M Batson R M Holt H E Morris E S Rennilson J J Whitaker E A	1969	J Geophys Res1969，74，：	1
20	A new integrated genetic linkage map of the soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and App lied Genetics2004，109，1：	1

返回顶部每页显示：

共20页首页上一页第1页下一页末页 /20 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示