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| 1 | Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine显示文摘由几抗原组成的多价的疫苗的发展是对不同寄生虫紧张和寄生虫生命周期阶段创造宽广范围的保护的一条新奇途径。我们以前证实了血吸虫 Sm21.7 和 Sm Fimbrin (SmFim ) 蛋白质能在老鼠导致保护。因此,这研究试图构造多价的 DNA 疫苗的 Sm21.7-SmFim/pBudCE4.1 并且评估它的有免疫力的功效。二血吸虫 mansoni 基因, Sm21.7 和 SmFim 的开的读物框架,被插入到为独立人士设计的真核细胞的表示原生质标志 pBudCE4.1 在哺乳动物的房间的二基因的表示。评估在里面在老鼠的多价的 Sm21.7-SmFim/pBudCE4.1 DNA 疫苗和它的免疫学的效果的 vitro 表示, recombinant 原生质标志 Sm21.7-SmFim/pBudCE4.1 习惯于 mRNA 的 transfect 293T 房间,和表示,蛋白质用反向的抄写聚合酶链反应和蛋白质印迹分析被检验。然后 Sm21.7-SmFim/pBudCE4.1 到的能力免于 S。mansoni 挑战感染在老鼠的种痘以后根据蠕虫负担和鸡蛋减小率被分析。种牛痘的老鼠出现了保护(56%) 的重要水平,和在数字和尺寸的减少,和在细胞的侧面的变化, granulomas。分别地,在肝和肠的鸡蛋减小是 41.53% 和 55.63% 相对仅仅收到了空向量的老鼠同样坚定。除了在蠕虫生存能力的减小,蠕虫肥沃和鸡蛋孵化能力被观察在使免疫的组跟随挑战感染。结果证明 Sm21.7-SmFim/pBudCE4.1 能表示 Sm2 1.7 和 SmFim mRNA 和蛋白质。连接酶的免疫吸着剂试金和蛋白质印迹分析显示使免疫的老鼠对 Sm21.7-SmFim/pBudCE4.1 产生了特定的免疫球蛋白 G。这些结果与多价的 S 建议那种痘。mansoni DNA 疫苗(SmFim-Sm21.7/pBudCE4.1 ) 不仅在蠕虫和卵负担导致重要减小,而且显著地减少卵 granulomas 的尺寸。在摘要,多价的疫苗与保护的重要水平刺激了特定的免疫并且反病理学的效果。 | Mahmoud H Romeih Hanem M Hassan Tarek S Abou Shousha Mohamed A Saber | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 3 |
| 2 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 3 | Oestrogen receptor negativity as a marker for high grade cluetal carcinoma in situ of the beast显示文摘 | Baqai T Shousha S | 2003 | Histopathology2003，42，5： | 1 |
| 4 | An immunohistochemical survey of pS2 expression in human epithelial cancers显示文摘 | Luqmani YA Ryall G Shousha A | 1992 | lnt J Cancer1992，50，： | 1 |
| 5 | ABCD classification system: a novel classifica- tion for subaxial cervical spine injuries显示文摘 | Shousha M | 2014 | Spine2014，39，9： | 1 |
| 6 | Light and electron microscopic study of an invasive cribriform carcinoma with extensive microcalcification developing in a breast with silicone augmentation显示文摘 | Shousha S Schoenfeld A Moss J | 1994 | Ultrast Pathol1994，18，： | 1 |
| 7 | Oestrogen receptor negativity as a marker for high-grade ductal carcinoma in situ of the breast显示文摘 | Baqai T Shousha S | 2003 | Histopathology2003，42，5： | 1 |
| 8 | Morphologic spectrum of estrogen re- ceptor- negative treast carcinoma显示文摘 | Scawn R Shousha S | 2002 | Arch Pathol Lab Med2002，126，32： | 1 |
| 9 | Malignnat adenomyoepithelioma of the breast with lymph node metastasis: a detailed study显示文摘 | Awamleh AA Gudi M Shousha S | 2012 | Case Rep Pathol2012，2012，30： | 1 |
| 10 | Automated diagnosis and staging of Fuchs’endothelial cell corneal dystrophy using deep learning显示文摘Background:To describe the diagnostic performance of a deep learning algorithm in discriminating early-stage Fuchs’endothelial corneal dystrophy(FECD)without clinically evident corneal edema from healthy and late-stage FECD eyes using high-definition optical coherence tomography(HD-OCT).Methods:In this observational case-control study,104 eyes(53 FECD eyes and 51 healthy controls)received HDOCT imaging(Envisu R2210,Bioptigen,Buffalo Grove,IL,USA)using a 6 mm radial scan pattern centered on the corneal vertex.FECD was clinically categorized into early(without corneal edema)and late-stage(with corneal edema).A total of 18,720 anterior segment optical coherence tomography(AS-OCT)images(9180 healthy;5400 early-stage FECD;4140 late-stage FECD)of 104 eyes(81 patients)were used to develop and validate a deep learning classification network to differentiate early-stage FECD eyes from healthy eyes and those with clinical edema.Using 5-fold cross-validation on the dataset containing 11,340 OCT images(63 eyes),the network was trained with 80%of these images(3420 healthy;3060 early-stage FECD;2700 late-stage FECD),then tested with 20%(720 healthy;720 early-stage FECD;720 late-stage FECD).Thereafter,a final model was trained with the entire dataset consisting the 11,340 images and validated with a remaining 7380 images of unseen AS-OCT scans of 41 eyes(5040 healthy;1620 early-stage FECD 720 late-stage FECD).Visualization of learned features was done,and area under curve(AUC),specificity,and sensitivity of the prediction outputs for healthy,early and late-stage FECD were computed.Results:The final model achieved an AUC of 0.997±0.005 with 91%sensitivity and 97%specificity in detecting early-FECD;an AUC of 0.974±0.005 with a specificity of 92%and a sensitivity up to 100%in detecting late-stage FECD;and an AUC of 0.998±0.001 with a specificity 98%and a sensitivity of 99%in discriminating healthy corneas from all FECD.Conclusion:Deep learning algorithm is an accurate autonomous novel diagnostic tool of FECD with very high sensitivity and specificity that can be used to grade FECD severity with high accuracy. | Taher Eleiwa Amr Elsawy EyüpÖzcan Mohamed Abou Shousha | 2020 | Eye and Vision2020，7，1： | 1 |
| 11 | Oestrogen receptor negativity as a marker for high-grade ductal carcinoma in situ of the breast 显示文摘 | Baqai T Shousha S | 2003 | Histopathology2003，42，5： | 1 |
| 12 | A generalized tanh law mosfet model and its applications to CMOS Inverters 显示文摘 | Aboulwafa M | 1993 | IEEE Journal of Solid-state Circuit1993，28，2： | 1 |
| 13 | Ultra-high resolution optical coherence tomography for imaging the anterior segment of the eye显示文摘 | Wang J Abou Shousha M Perez VL | 2011 | Ophthalmic Surg Lasers Imaging2011，42，： | 1 |
| 14 | Breast carcinoma developing in patients on hormone replacement therapy:a histological and immtmohistological study显示文摘 | O' ODNNOR I F SCHEMBEKAR M V Shousha | 1998 | J Clin Pathol1998，51，： | 1 |
| 15 | Architecture-based perfrmance analysis applied to a telecommunication system显示文摘 | PETRIU D C SHOUSHA C JALNAPURKAR A | 2000 | IEEE Transactions on Software Engineering2000，26，10： | 1 |
| 16 | Breast carcinoma presenting during or shortly after pregnancy and lactation显示文摘 | Shousha S | 2000 | Arch Pathol Lab Med2000，124，7： | 1 |
| 17 | Cataract surgery after pars plana vitrecto- my显示文摘 | Shousha MA Yoo SH | 2010 | Current Opinion in Ophthalmol2010，21，1： | 1 |
| 18 | Adenoid cystic carcinoma of the breast: a tumour commonly devoid of oes- trogen receptors and related proteins 显示文摘 | TRENDELL SMITH N J PESTON D SHOUSHA S | 1999 | Histopathology1999，35，3： | 1 |
| 19 | Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography显示文摘 | Shousha MA Karp CL Perez VL | 2011 | Ophthalmology2011，118，： | 1 |
| 20 | Predictive Value of Biochemical Markers In Pregnancy Induced Hypertension显示文摘 | Farag M Shousha W El-Bassyouni H | 2009 | Egyptian Journal of Biochemistry and Molecular Biology2009，26，： | 1 |
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