|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The relationship between affect expression and affect recognition in shchizophrenia显示文摘 | Show RJ Dong M Urn KO | 1999 | Schizophrenia Research1999,37,: | 1 |
| 2 | 显示文摘 | Show Y Matsuoka F Hayashi M | 1998 | Appl Phys1998,84,: | 1 |
| 3 | Hypokalemia in Chinese peritoneal diaysis patients:prevalence and prognostic implication 显示文摘 | Szeto C C Show K M Kwan B C | 2005 | Am J Kidney Dis2005,46,1: | 1 |
| 4 | Indolopyrido quinazoline al- kaloids with antiplatelet aggregation activity from zanthoxlum in- tergrifoliolum 显示文摘 | Show W S Tsai IL Teng C M | 1996 | Phytochemistr1996,62,2: | 1 |
| 5 | The Geological Implication of Steady- State Meehanisms in Catastrophe Theory 显示文摘 | John M Cubitt Brian show | 1976 | Mathematical Geology1976,8,6: | 1 |
| 6 | Electrochemical performance of diamond thin-film electrodes from different commercial sources 显示文摘 | FISHER A E SHOW Y SWAIN G M | 2004 | Anal Chem2004,76,: | 1 |
| 7 | Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease显示文摘AIM To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODS The thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease(IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy recipients.RESULTS Complete blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the timeof sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer(NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T(MAIT) cells, invariant natural killer T(i NKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells(Tregs) or na?ve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iN KT and MAIT cells than healthy controls. CONCLUSION Thiopurine use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients. | James D Lord Donna M Shows | 2017 | World Journal of Gastroenterology2017,23,18: | 1 |
| 8 | A study of microRNAs insilico and in vivo:bioinformatics approaches to microRNAdiscovery and target identification显示文摘 | Yousef M Showe L Showe M | 2009 | FEBS J2009,276,8: | 1 |
| 9 | He-parin and heparan sulfate bind interleukin-10 and modulate its activity 显示文摘 | ARRAND J R SHOW D MACKETT M | 2000 | Blood2000,96,5: | 1 |
| 10 | Predicting the depth of insertion of left - sided double - lumen endobronehial - tubes显示文摘 | Show M Y Gob M H Ti L K | 2002 | Cardiothorac Vasc Anesth2002,16,2: | 1 |
| 11 | E arly growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcription显示文摘 | M osteck i J Show alter BM Rothm an PB | 2005 | J B iol Chom2005,280,: | 1 |
| 12 | Increased in output power from fuel cell used metal bipolar plate coated with a-C film 显示文摘 | Show Y Miki M Nakamura T | 2007 | Diamond Relat Mater2007,16,47: | 1 |
| 13 | IFN-γ mediated a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression显示文摘 | SEDGER L M SHOWS D M BLANTON R A | 1999 | J Immunol1999,163,2: | 1 |
| 14 | An evidence-based appraisal of retlux disease management-The Genval Workshop Report显示文摘 | Dent J Fendrick AM Fennerty MB Janssens J Kahrilas PJ Lauristen K Reynolds JC Show M Tally NJ | 1999 | Gut1999,44,12: | 1 |
| 15 | Increased metallothionein gene expression,zinc,and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia显示文摘 | Raymond A D Gekonge B Giri M S Hancock A Papasavvas E Chehimi J Kossenkov A V Nicols C YousefM Mounzer K Shull J Kostman J Showe L Montaner L J | | 0,,03: | 1 |
| 16 | Cloning and structural characterization of a human non-erytheroid band 3-like protein显示文摘 | Denuth DR Showe IC Ballantle M | 1986 | EMBO J1986,5,: | 1 |
| 17 | Form- determining function of the genes required for the assembly of the head of bacteriophage T4显示文摘 | Laemmli U K Molbert E Showe M | | 0,,01: | 1 |
| 18 | Influence of width of fertilized band of soil burley tobacco to nitrogen and phosphorus 显示文摘 | Whitty B E McCants M Show L | 1966 | Tobacco Science1966,,10: | 1 |
| 19 | Shock State from Initially Liquid Oxygen-Nitrogen System显示文摘 | Scholl G L Show M S Johnson J D | 1985 | J Chem Phys1985,82,9: | 1 |
| 20 | Influence of width of fertilized band of soil burley tobacco to nitrogen and phosphorus 显示文摘 | WhittY B E McCants M Show L | 1966 | Tobacco Science1966,,10: | 1 |