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| 1 | Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients显示文摘Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation. | LI NING LI DONG QING ZHANG KUANG YAN ZHOU ANNIE CARTMAN JEAN YVES LEROUX A ROBIN POOLE YI PING ZHANG ( Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)(Joint Diseases Laboratory, Shriners Hospital, Dep | 2000 | Cell Research2000，10，1： | 7 |
| 2 | An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects 显示文摘 | Yi N J Shriner D Banerjee S | 2007 | Genetics2007，176，3： | 1 |
| 3 | Landscape change in the Midwest: An integrated research and development program 显示文摘 | Gobster P H Haight R G Shriner D | 2000 | Journal of Forestry2000，98，： | 1 |
| 4 | Spatial autocorrelation and autoregressive models in ecology 显示文摘 | LICHSTEIN J W SIMONS T R SHRINER S A | 2002 | Ecological Monographs2002，72，： | 1 |
| 5 | Novel Blends of Hyperbranched Polyesters and Linear Polymers 显示文摘 | Massa D J Shriner K A Turner S R | 1995 | Macromolecules1995，28，： | 1 |
| 6 | Spatial auto-correlation and autoregressive models in ecology显示文摘 | Lichstein J W Simons T R Shriner S A | | 0，，03： | 1 |
| 7 | Replication of genome-wide association studies(GWAS)loci for fasting plasma glucose in African-Americans显示文摘 | Ramos E Chen G Shriner D | | 0，，： | 1 |
| 8 | Detection of gene x gene interactions in genome-wide association studies of human population data显示文摘 | Musani S K Shriner D Liu N | 2007 | Hum Hered2007，63，2： | 1 |
| 9 | 显示文摘 | Massa D J Shriner K A Turner S R | 1995 | Macromolecules1995，28，9： | 1 |
| 10 | Mohs micrographic surgery显示文摘 | Shriner DL McCoy DK Goldberg DJ | 1998 | J Am Acad Dermatol1998，39，1： | 1 |
| 11 | Novel blends of hyperbranched polyesters and linear polymers显示文摘 | Maesa D J Shriner K A Tumer S R | 1995 | Maeromolecules1995，28，9： | 1 |
| 12 | Novel blends of hyperbranched polyesters and linear polymers 显示文摘 | Massa D J Shriner K A Turner S R | 1995 | Maeromolecules1995，28，9： | 1 |
| 13 | Novel Blends of Hyperbranched Polyesters and Linear Polymers显示文摘 | Massa D Shriner K A | 1995 | Macromolecules1995，28，： | 1 |
| 14 | The chemistry of the amidines 显示文摘 | Shriner R L Neumann F W | 1944 | Chem Bey1944，35，3： | 1 |
| 15 | Western equine encephalitis in avian populations in North Dakota, 1975 显示文摘 | McLean RG Shriner RB Kirk LJ | 1989 | J Wildl Dis1989，25，4： | 1 |
| 16 | 2-Phenylindole显示文摘 | Shriner R L Ashley W C Welch E | 1955 | Organic Syntheses1955，3，： | 1 |
| 17 | Dose-dependent loss of motor function after unilateral medial forebrain bundle ro-tenone lesion in rats:a cautionary note显示文摘 | Klein A Gidyk DC Shriner AM | 2011 | Behav Brain Res2011，222，1： | 1 |
| 18 | valuating Improvements in Landside Access for Airports 显示文摘 | Shriner H W and Hoel L A | 1999 | Transportation Research Record 16621999，，： | 1 |
| 19 | The preparation and propertiesm of certain sulfoxides and sulfones显示文摘 | Shriner R L Struck H C Jorison W J | 1930 | J A C S1930，52，3： | 1 |
| 20 | Novel Blends of Hyperbranched Polyesters and Linear Polymers显示文摘 | Massa D J Shriner K A Turner S R | 1995 | Macromolecules1995，28，： | 1 |
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