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| 1 | Regulation of DNA double-strand break repair pathway choice显示文摘脱氧核糖核酸双海滨裂缝(DSB ) 是能包括大规模或小规模的删除,杂合现象的损失, translocations,和染色体损失导致房间死亡或许多基因改变的批评损害。DSB 被修理由非相应加入结束(NHEJ ) 并且相应再结合(HR ) ,和在这些小径的缺点引起染色体不稳定性并且支持 tumorigenesis。DSB 包括直接或间接地损坏脱氧核糖核酸并且通常在癌症治疗被使用的离子辐射和化学药品包括在细胞的新陈代谢,折叠复制叉,和核酸酶期间产生的反应的氧种类从内长的来源,并且从外长的来源产生。DSB 修理小径看起来竞争因为在他们之间的 DSB,而是平衡在种之中广泛地不同,在单个种的不同细胞类型之间,并且在一个单身者的不同细胞周期阶段期间,细胞打字。这里,我们考察在酵母和更高的优核质由 NHEJ 和 HR 调整 DSB 修理的规章的因素。这些因素包括修理蛋白质,修理因素可接近性的染色质调整,和相应修理模板的可获得性的调整表示和磷酸化。当大多数 DSB 修理蛋白质看起来专门在 NHEJ 或 HR 工作时,很多蛋白质影响两条小径,包括 MRE11/RAD50/NBS1 (XRS2 ) 建筑群, BRCA1,嘘一 H2AX, PARP-1, RAD18, DNA 依赖的蛋白激酶催化子单元(DNA-PKcs ) ,和 ATM。DNA-PKcs 在哺乳动物的 NHEJ 起一个作用,但是它也通过可以与涉及是由 DNA-PKcs 的 phosphorylated 的 HR 的至少 12 蛋白质的 ATM 或 ATM 包含串音的一个复杂规章的网络影响 HR。 | Meena Shrivastav Leyma P De Haro Jac A Nickoloff | 2008 | Cell Research2008，18，1： | 67 |
| 2 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 3 | Quantitation of tadalafil in human plasma using a sensitive and rapid LC-MS/MS method for a bioequivalence study显示文摘A highly sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) method was developed for the determination of tadalafil(TAD) in human plasma. TAD and its deuterated internal standard(IS), tadalafil-d3, were extracted from 200 mL plasma using Phenomenex Strata-X-C 33 m extraction cartridges. Chromatographic analysis was carried out on Synergi? Hydro-RP C18(100 mm ? 4.6 mm, 4 mm)column with a mobile phase consisting of methanol and 10 m M ammonium formate, p H 4.0(90:10, v/v),delivered at a flow rate of 0.9 m L/min. Quantitation of the protonated analyte was done on a triple quadrupole mass spectrometer using multiple reaction monitoring via electrospray ionization. The precursor to product ions transitions monitored for TAD and TAD-d3 were m/z 390.3-268.2 and m/z393.1-271.2, respectively. The calibration curve was linear over the concentration range of 0.50–500 ng/m L with correlation coefficient, r2 Z 0.9994. Acceptable intra-batch and inter-batch precision(r3.7%) and accuracy(97.8% to 104.1%) were obtained at five concentration levels. The recovery of TAD from spiked plasma was highly precise and quantitative(98.95% to 100.61%). Further, the effect of endogenous matrix components was minimal. TAD was found to be stable under different storage conditions in human plasma and also in whole blood samples. The validated method was successfully used to determine TAD plasma concentration in a bioequivalence study with 20 mg TAD tablets in 24 healthy volunteers. Method performance was evaluated by reanalyzing 115 study samples. | Abhaysingh Bhadoriya Bhavesh Dasandi Dharmesh Parmar Priyanka A. Shah Pranav S. Shrivastav | 2018 | Journal of Pharmaceutical Analysis2018，8，4： | 4 |
| 4 | Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in human plasma by LC-MS/MS to support a bioequivalence study显示文摘A simple,precise and rapid liquid chromatography-tandem mass spectrometry(LC-MS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oseltamivir carboxylate,a neuraminidase inhibitor,using their deuterated analogs as internal standards(ISs).The method involved solid phase extraction of the analytes and ISs from 200 μL human plasma with no reconstitution and drying steps.The chromatographic separation was achieved on a Symmetry C18(100 mm 4.6 mm,5 μm) column using 10 mM ammonium formate and acetonitrile(30:70,v/v) as the mobile phase in a run time of 2.0 min.Quantitation of analytes and ISs were done by multiple reaction monitoring on a triple quadrupole mass spectrometer in the positive ionization mode.The linearity of the method was established in the concentration range of 0.5-200 ng/mL and 2.0-800 ng/mL for oseltamivir and oseltamivir carboxylate respectively.The mean extraction recovery for oseltamivir(94.4%) and oseltamivir carboxylate(92.7%) from spiked plasma samples was consistent and reproducible.The application of this method was demonstratedby a bioequivalence study in 42 healthy Indian subjects with 75 mg oseltamivir phosphate capsules.The assay reproducibility was established by reanalysis of 151 incurred subject samples. | Ajay Gupta Swati Guttikar Pranav S. Shrivastav Mallika Sanyal | 2013 | Journal of Pharmaceutical Analysis2013，3，3： | 3 |
| 5 | 电解对蔗糖-盐络合物影响的研究显示文摘蔗糖分子与各种不同的阳离子(K+、Na+、Ca2 + )形成络合物的倾向是一种非常有意思的现象。这种蔗糖-盐络合物即各种不同盐与蔗糖分子结合在一起的糖络合物可使蔗糖溶解度增大,结合的蔗糖分子就不能被结晶。这就引起更高纯度糖蜜的形成以及更高的糖蜜产量,结果导致糖厂巨大的经济损失。这就是众所周知的盐的造蜜性质。在本文中作者试图通过电解过程将蔗糖-盐络合物分开,使糖蜜中糖分的损失减至最小。将不同浓度的各种蔗糖-盐溶液(K+、Na+ 、Ca2 + )在4、8和12 V电压下电解180 m in。在电解进行过程中离子浓度先是下降,然后升高到一个定值,同时测定一定时间间隔下p H和电导率的变化。在分开蔗糖-盐络合物的过程中不需化学药品,因此这个过程被认为是一种生态友好型的技术。 | Rakesh Shrivastav L.P.Tewari 马月飞 孙卫东 | 2005 | 广西轻工业2005，21，4： | 3 |
| 6 | Percutaneous nephrolithotomy for complex caliceal calculi and staghorn stones in children less than 5 years of age显示文摘 | Manohar T Ganpule AP Shrivastav P | 2006 | Journal of Endocrinology2006，，08： | 2 |
| 7 | Liquid chromatography tandem mass spectrometry method for simultaneous determination of antidiabetic drugs metformin and glyburide in human plasma 显示文摘 | Mistri H N Jangid A G Shrivastav P S | 2007 | Pharm Biomed Anal2007，45，： | 1 |
| 8 | Comparison of pregnancy outcome of pronuclear-and muhicelllular-stage frozen-thawed embryo transfers显示文摘 | Kattrea S Shrivastav P Craft I | 1999 | Assist Reprod Genet1999，16，7： | 1 |
| 9 | Dermatomyositis associated with acute myelocytic leukemia 显示文摘 | Shrivastav A Kumar V Pal J | 2010 | Rheumatol Int2010，30，5： | 1 |
| 10 | DNA-PKcs and ATM co-regulate DNA double-strand break repair显示文摘 | Meena Shrivastav Cheryl A. Miller Leyma P. De Haro Stephen T. Durant Benjamin P.C. Chen David J. Chen Jac A. Nickoloff | 2009 | DNA Repair2009，，8： | 1 |
| 11 | Interactions of PI3K/Akt/mTOR and estrogen receptor signaling in breast cancer显示文摘 | Shrivastav A Murphy L | 2012 | Breast Cancer Manage2012，1，3： | 1 |
| 12 | Development of feeder routes for suburban railway stations using heuristic approach 显示文摘 | SHRIVASTAV P DHINGRA S | 2001 | Journal of Transportation Engineering2001，127，4： | 1 |
| 13 | Joint MAP channel estimation and data detection for OFDM in presence of phase noise from free running and phase locked loop oscillator显示文摘This paper addresses a computationally compact and statistically optimal joint Maximum a Posteriori(MAP)algorithm for channel estimation and data detection in the presence of Phase Noise(PHN)in iterative Orthogonal Frequency Division Multiplexing(OFDM)receivers used for high speed and high spectral efficient wireless communication systems.The MAP cost function for joint estimation and detection is derived and optimized further with the proposed cyclic gradient descent optimization algorithm.The proposed joint estimation and detection algorithm relaxes the restriction of small PHN assumptions and utilizes the prior statistical knowledge of PHN spectral components to produce a statistically optimal solution.The frequency-domain estimation of Channel Transfer Function(CTF)in frequency selective fading makes the method simpler,compared with the estimation of Channel Impulse Response(CIR)in the time domain.Two different time-varying PHN models,produced by Free Running Oscillator(FRO)and Phase-Locked Loop(PLL)oscillator,are presented and compared for performance difference with proposed OFDM receiver.Simulation results for joint MAP channel estimation are compared with Cramer-Rao Lower Bound(CRLB),and the simulation results for joint MAP data detection are compared with“NO PHN'performance to demonstrate that the proposed joint MAP estimation and detection algorithm achieve near-optimum performance even under multipath channel fading. | Kamayani Shrivastav R.P.Yadav K.C.Jain | 2021 | Digital Communications and Networks2021，7，1： | 1 |
| 14 | A rare germ-cell tumor site:vaginal endodermal sinus tumor显示文摘 | Arora M Shrivastav RK Jaiprakash MP | 2002 | Pediatr Surg Int2002，18，56： | 1 |
| 15 | Bipolar versus monopolar transurethral resection of prostate:randomized controlled study显示文摘 | Singh H Desai MR Shrivastav P | 2005 | J Endourol2005，19，3： | 1 |
| 16 | Effect of preservatives for food grade C-PC from Spirulinaplatensis显示文摘 | MISHRA S K SHRIVASTAV A MISHRA S | 2008 | Process Biochemistry2008，43，： | 1 |
| 17 | Sperm function and structure and seminal plasma prostanoid concentrations in men with IDDM 显示文摘 | Shrivastav P Swarm J Jeremy JY | 1989 | Diabetes Care1989，12，10： | 1 |
| 18 | Esthesioneuroblastoma presenting with proptosis and bilateral neck metastasis:an unusual presentation显示文摘 | Aggarwa1 SK Kumar R Shrivastav A | 2011 | J Pediatr Neurosci2011，6，1： | 1 |
| 19 | Day care management of severe ovarian hypersteimulation sydrome avoids hospitalization and morbidity显示文摘 | Shrivastav P Nadkarni P Craft I | 1994 | Hum reprod1994，9，5： | 1 |
| 20 | Solvent extraction, spectrophotometric and inductively coupled plasma atomic emission spectroscopic determination of lanthanum with crown hydroxamic acid 显示文摘 | Yadvendra K Agrawal Pranav Shrivastav | 1997 | Talanta1997，44，： | 1 |
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