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| 1 | Single-cell Transcriptomes Reveal Characteristics of MicroRNAs in Gene Expression Noise Reduction显示文摘Isogenic cells growing in identical environments show cell-to-cell variations because of the stochasticity in gene expression.High levels of variation or noise can disrupt robust gene expression and result in tremendous consequences for cell behaviors.In this work,we showed evidence from single-cell RNA sequencing data analysis that microRNAs(miRNAs)can reduce gene expression noise at the mRNA level in mouse cells.We identified that the miRNA expression level,number of targets,target pool abundance,and miRNA-target interaction strength are the key features contributing to noise repression.miRNAs tend to work together in cooperative subnetworks to repress target noise synergistically in a cell type-specific manner.By building a physical model of post-transcriptional regulation and observing in synthetic gene circuits,we demonstrated that accelerated degradation with elevated transcriptional activation of the miRNA target provides resistance to extrinsic fluctuations.Together,through the integrated analysis of single-cell RNA and miRNA expression profiles,we demonstrated that miRNAs are important post-transcriptional regulators for reducing gene expression noise and conferring robustness to biological processes. | Tao Hu Lei Wei Shuailin Li Tianrun Cheng Xuegong Zhang Xiaowo Wang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 2 | Regulation by competition:a hidden layer of gene regulatory network显示文摘Background:Molecular competition brings about trade-offs of shared limited resources among the cellular components,and thus introduces a hidden layer of regulatory mechanism by connecting components even without direct physical interactions.Several molecular competition scenarios have been observed recently,but there is still a lack of systematic quantitative understanding to reveal the essence of molecular competition.Methods:Here,by abstracting the analogous competition mechanism behind diverse molecular systems,we built a unified coarse-grained competition motif model to systematically integrate experimental evidences in these processes and analyzed general properties shared behind them from steady-state behavior to dynamic responses.Results:We could predict in what molecular environments competition would reveal threshold behavior or display a negative linear dependence.We quantified how competition can shape regulator-target dose-response curve,modulate dynamic response speed,control target expression noise,and introduce correlated fluctuations between targets.Conclusions:This work uncovered the complexity and generality of molecular competition effect as a hidden layer of gene regulatory network,and therefore provided a unified insight and a theoretical framework to understand and employ competition in both natural and synthetic systems. | Lei Wei Ye Yuan Tao Hu Shuailin Li Tianrun Cheng Jinzhi Lei Zhen Xie Michael Q.Zhang Xiaowo Wang | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，2： | 1 |
| 3 | TiO_(2)bunchy hierarchical structure with effective enhancement in sodium storage behaviors显示文摘Bronze phase TiO_(2)[TiO_(2)(B)]has great research potential for sodium storage since it has a higher theoretical capacity and ion mobility compared with other phases of TiO_(2).In this case,preparing porous TiO_(2)(B)nanosheets,which can provide abundant sodium insertion channels,is the most effective way to improve transport kinetics.Here,we use the strong one-dimensional TiO_(2)nanowires as the matrix for stringing these nanosheets together through a simple solvothermal method to build a bunchy hierarchical structure[TiO_(2)(B)-BH],which has fast pseudocapacitance behavior,high structural stability,and effective ion/electron transport.With the superiorities of this structure design,TiO_(2)(B)-BH has a higher capacity(131 vs.70 mAh g^(−1)[TiO_(2)-NWs]at 0.5 C).And it is worth mentioning that the reversible capacity of up to 500 cycles can still be maintained at 85 mAh g^(−1)at a high rate of 10 C.Meanwhile,we also further analyzed the sodium storage mechanism through the ex-situ X-ray powder diffraction test,which proved the high structural stability of TiO_(2)(B)-BH in the process of sodiumization/de-sodiumization.This strategy of uniformly integrating nanosheets into a matrix can also be extended to preparing electrode material structures of other energy devices. | Shen Liu Kai Niu Shuailin Chen Xin Sun Lehao Liu Bing Jiang Lihua Chu Xiaojun Lv Meicheng Li | 2022 | Carbon Energy2022，4，4： | 0 |
| 4 | Nanostructured AlFeO_(3) thin films as a novel photoanode for photoelectrochemical water splitting显示文摘The earth-abundant and robust aluminum ferrite,AlFeO_(3)(AFO),is mainly studied in the context of ferroelectrics.Herein,we demonstrate that AFO can be used as a stable solar absorber in photoelectrochemical cells for solar water splitting,exhibiting attractive performance.This is the first report on the photoelectrochemical activity of AFO.AFO thin-film photoelectrodes prepared by solution-processing methods are composed of vertically oriented thin nanosheets,featuring the rhombohedral symmetry(R3c)and n-type conductivity.The as-prepared AFO photoanodes generate a photocurrent density of+0.78 mA·cm^(-2) at 1.23 V vs.reversible hydrogen electrode(RHE)with the photocurrent _(onset) potential(U_(onset))close to the flat band potential of 0.5 V vs.RHE in the presence of hole scavengers.Remarkably,the U_(onset) of AFO for solar water splitting coincides with the flat band potential as well,which is rare in n-type inorganic absorbers.We also report other properties of AFO associated with photoelectrochemical performance.AFO films exhibit a band gap energy of 2.31 eV and positive band edges with low dispersion.Moreover,the carrier lifetimes in AFO films are up to millisecond timescales under the mediation of defect traps.Based on the photoelectrochemical behavior and optoelectronic properties,we believe that AFO has great potential for application in photoelectrochemical cells. | Xin Sun Min Wang Qi Geng Shuailin Chen Xiaojun Lv Xunlei Ding Meicheng Li | 2024 | Nano Research2024，17，3： | 0 |
| 5 | How the development of barren land into orchards affects soil ecosystem in Tibet,China显示文摘Fruit production is an important strategy for alleviating poverty on the Tibetan Plateau and leads to the conversion of natural barren land into orchards.This study aimed to understand how the conversion of barren land to peach(Prunus persica)orchards affects soil nutrients,heavy metals,and fungal communities in the 0–40 cm profile(at 20 cm intervals)in an experiment including three treatments,barren land(BL),peach orchards planting for 4 years(Y4),and peach orchards planting for 10 years(Y10).Results of the experiment showed that compared with BL,Y4 reduced the availability of some macronutrients(N and K)and micronutrients(Fe and Mn)due to the exclusive application of chemical fertilizer at the seedling stage.Conversely,Y10,which included six years of green cultivation management,using a combination of sheep manure and chemical fertilizer as well as alfalfa(Medicago sativa Linn)intercropping,effectively improved soil macronutrients,but did not enhance the availability of Fe and Mn.Although the investigated heavy metals(As,Hg,Pb,Cr,and Cd)in both the Y4 and Y10 soils were found to pose a low risk to food safety and soil environment,Hg,Cr,and As tended to accumulate in the subsoil(20–40 cm).Furthermore,the variations in the fungal community composition and functional groups were mainly driven by the interaction effects of macronutrients,micronutrients,and heavy metals,but their independent contribution to specific key functional groups cannot be overlooked.For example,Y4 and Y10 decreased the relative abundance of soil saprotrophic and lichenized fungi,mainly due to the loss of micronutrients(Fe and Mn).However,as a result of macronutrient input and dung saprotrophic fungi enrichment,orchard soils promoted the growth of pathogens that play critical roles in fungal co-occurrence networks.These findings indicate that supplementation with N or K fertilizer or manure at the seedling stage and fertilizers rich in Fe and Mn throughout the growth period would be beneficial to the balance of soil nutrients and provide insights into linking the variations in soil nutrients and heavy metals to the function of the fungal community during the conversion of barren land to orchards in alpine soil ecosystems.The risks posed by heavy metal accumulation and fungal pathogen enrichment should be actively prevented. | Shuailin LI Shuo WANG Xiuli ZENG Yongxing CUI Wantai YU Qiang MA | 2022 | Pedosphere2022，32，4： | 0 |
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