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您的检索式：作者名="Shuaiwei Qi"
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| 1 | Responsive Polymers with Contraction-arisen Helicity and Biomimetic Membrane-spanning Transport Functions显示文摘Responsive polymers have attracted increasing attention for prospective design of smart materials.The development of multifunctional responsive materials is very dependent on polymeric structures that can be manipulated with the change of microenvironment at the molecular level.Herein,we report a type of responsive coordination polymers(RCPs)consisting of dual phenanthroline-oxadiazole(DPO)units and metal Zn^(2+)ions,which can contract from linear structure into topologically helical structure driven by hydrophobic effect while changing the microenvironment from nonpolar solvent to aqueous media.The symmetry breaking of RCPs was confirmed by circular dichroism(CD)spectra and atomic force microscope(AFM)images,clearly demonstrating the intramolecularly contraction-arisen helicity.Moreover,RCPs can intelligently adapt different microenvironments by changing their conformations,as evidenced by a demonstration of biomimetic lipid bilayer-based vesicle experiments.Furthermore,RCPs show significant concentration-dependent transmembrane transport functions,implying that RCPs are able to span cellular membranes to form channels inside the hydrophobic lipid bilayers.At the same time,the electrophysiological conductance experiments further underpin the biomimetic transport functions and channel-based conduction mechanism of RCPs.This study demonstrates an important paradigm of responsive polymers performing microenvironment-induced conformational change and thereof unique functions,and thus provides valuable insights on the development of functional responsive materials. | MIN Jing ZHANG Chenyang QI Shuaiwei WANG Liyan DONG Zeyuan | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 2 | Unimolecular Transmembrane Na^(+) Channels Constructed by Pore-Forming Helical Polymers with a 2.3A Aperture显示文摘To understand the relationships between channel size and ion selectivity,we have developed a new type of artificial ion channel based on pore-forming helical polymers consisting of phenanthrolineoxadiazole units with a pore aperture 2.3A close to the diameter of the Na^(+)ion(2.04A).Successful preparation of high molecular weight helical polymers(HP1)gives rise to a 4.6 nm long artificial unimolecular transmembrane channel.The transport property of artificial channel HP1 was elaborately investigated by means of vesicle-based kinetic assay and symmetry/asymmetry bilayer membrane(BLM)experiments as well.These results unambiguously demonstrate that HP1 is a Na^(+)-selective channel with extremely high transport activity(EC_(50)=0.017 mol% relative to lipid).Moreover,the Na^(+)/K^(+)selectivity ratio of HP1 reaches 1.9,as determined by asymmetry BLM experiments.Owing to the narrowest 2.3A size constraint so far,HP1 transport naked Na^(+)ion across the membrane,which represents a different Na^(+)transport mode from that of natural Na^(+)channels,which transports partially hydrated Na^(+)ions during transmembrane conduction.This study provides crucial insights on the chemical basis of ion selectivity in the field of ion channels. | Shuaiwei Qi Jun Tian Jing Zhang Lei Zhang Chenyang Zhang Ze Lin Jing Min Shizhong Mao Zeyuan Dong | 2022 | CCS Chemistry2022，4，6： | 0 |
| 3 | Dimensionally confined nanosheets self-assembled through self-shielding multiple hydrogen bonding interactions in aqueous media显示文摘Herein,we adopt a simple supramolecular strategy to effectively control the tautomerism of ureidopyrimidinone(UPy)moiety and ultimately realize the complete arrangement of enol configuration.The obtained UPy derivatives containing self-complementary quadruple hydrogen bonding interactions can spontaneously self-assemble towards the formation of well-controlled,self-organized supramolecular nanostructure morphologies in both chloroform and water.The resulting aggregates had been fully characterized by various spectroscopy(absorption,emission)and microscopy(TEM,SEM and AFM)studies.It is anticipated that this study can provide an exact and excellent monomeric unit for controllable and precise supramolecular polymerization.The results achieved here also demonstrate the utility and feasibility of multiple hydrogen bonds to direct the self-assembly of small-molecule building blocks in aqueous media,which provides a strategy for the construction of well-defined and stable supramolecular architectures with chemical functionalities and physical properties as advanced materials for biological applications. | Jing Zhang Shuaiwei Qi Hao Yu Ze Lin Bao Li Ming Wang Zeyuan Dong | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
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