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| 1 | Research Progress in the Use of Drugs for Breast Cancer Targeted Therapy显示文摘In recent years,many significant advances have been made on molecular target therapy to aim directly at epidermal growth factor receptors and vascular endothelial growth factor in breast cancers.Clinical studies of such agents as trastuzumab,lapatinib,erlotinib and bevacituzumab have been widely conducted.This paper will review the recent research progress related to targeted therapy. | Shun 'e Yang Bing Zhao | 2008 | Chinese Journal of Clinical Oncology2008，5，5： | 22 |
| 2 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 3 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 4 | Primary studies on integration optimization of differential steering of electric vehicle with motorized wheels based on quality engineering显示文摘The model of the differential steering system(DSS) of electric vehicle with motorized wheels and the three-degree-of-freedom dynamic model of vehicle are built.Based on these models,the concepts and quantitative expressions of steering road feel,steering portability and steering stability are proposed.Through integrating the Monte Carlo descriptive sampling,elitist non-dominated sorting genetic algorithm(NSGA-II) and Taguchi robust design method,the system parameters are optimized with steering road feel and steering portability as optimization targets,and steering stability and steering portability as constraints.The simulation results show that the system optimized based on quality engineering can improve the steering road feel,guarantee steering stability and steering portability and thus provide a theoretical basis for the design and optimization of the electric vehicle with motorized wheels system. | ZHAO WanZhong WANG ChunYan SUN PeiKun LIU Shun | 2011 | Science China(Technological Sciences)2011，54，11： | 15 |
| 5 | Martensitic transformation involved mechanical behaviors and wide hysteresis of NiTiNb shape memory alloys | Minjuan Wang Mingyang Jiang Guangyue Liao Shun Guo Xinqing Zhao | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 6 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 7 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 8 | A New Triterpenoid Oligoglycoside Escin IVe from the Seeds ofAesculus Chinensis显示文摘A new triterpenoid saponin named escin IVr was isolated from the seeds ofAesculus chinensis its structure was established as 28-tigloylprotoaescigenin-3β-O-[β-D-glucopyranosyl (1-2 )][β-D-glucopyranosyl (1-4)] -β-D-glucopyranosiduronic acid. | Jing ZHAO Xiu Wei YANGI Yu Xin CUl Xue Hut LIU Shun He OUYANGZ(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083Yantai Luye Pharmaceutical Co. Ltd.. 43 Yingbin Road. Yantai. Shandong 264001) | 1999 | Chinese Chemical Letters1999，10，6： | 5 |
| 9 | Diversity of culturable heterotrophic bacteria from the Mariana Trench and their ability to degrade macromolecules显示文摘The Mariana Trench is the deepest location on earth and harbors unique microbial communities as evidenced by 16S rRNA gene amplicon and metagenomic sequencing.Obtaining culturable microorganisms from the Mariana Trench will contribute to a further understanding of hadal biogeochemical processes and act as a unique microbial reservoir with potential applications.Here,825 bacterial strains,identified by 16S rRNA gene sequencing,were isolated from 12 water depths(0-10,400 m)of the Mariana Trench with 2216E and R2A media at 4℃ or 28℃ on four cruises during 2015-2017.These bacteria belong to four phyla,nine classes,27 orders,45 families and 108 genera.Alphaproteobacteria,Gammaproteobacteria,Actinobacteria_c,Bacilli and Flavobacteriia were the most abundant classes,accounting for 37.9%,33.0%,11.8%,8.6%and 8.0%of the total bacterial isolates,respectively.2216E and R2A media were found to have a better selectivity to Bacilli and Flavobacteriia,respectively.Fifty strains were potential novel bacterial species with a 16S rRNA gene similarity<98.65%,and a higher percentage of novel strains were obtained from R2A than 2216E medium.Additionally,301(150 species)out of 354 strains(178 species)selected from each depth could degrade at least one of the ten kinds of macromolecules tested.These results indicate that there is a high diversity of culturable bacteria in the Mariana Trench and they can produce a variety of extracellular enzymes.Our study provides a valuable resource of microorganisms for investigating their biogeochemical roles in the Mariana Trench and for industrial applications. | Xiuxiu Zhao Jiwen Liu Shun Zhou Yanfen Zheng Yanhong Wu Kazuhiro Kogure Xiao-Hua Zhang | 2020 | Marine Life Science & Technology2020，2，2： | 5 |
| 10 | Effect of thermo-mechanical treatment on mechanical and elastic properties of Ti–36Nb–5Zr alloy显示文摘The evolutions of phase constitutions and mechanical properties of a β-phase Ti–36Nb–5Zr(wt%) alloy during thermo-mechanical treatment were investigated. The alloy consisted of dual(β t α″) phase and exhibited a double yielding phenomenon in solution treated state. After cold rolling and subsequent annealing at 698 K for 20 min, an excellent combination of high strength(833 MPa) and low modulus(46 GPa) was obtained. The high strength can be attributed to high density of dislocations, nanosized α phase and grain refinement. On the other hand, the low Young's modulus originates from the suppression of chemical stabilization of β phase during annealing, which guarantees the low β-phase stability. Furthermore, the single-crystal elastic constants of the annealed Ti–36Nb–5Zr alloy were extracted from polycrystalline alloy using an in-situ synchrotron X-ray technique. The results indicated that the low shear modulus C44 contributes to the low Young's modulus for the Ti–36Nb–5Zr alloy, suggesting that reducing C44 through thermo-mechanical treatment might be an efficient approach to realize low Young's modulus in β-phase Ti alloys. The results achieved in this study could be helpful to elucidate the origin of low modulus and sheds light on developing novel biomedical Ti alloys with both low modulus and high strength. | Qingkun Meng Qing Liu Shun Guo Yongqi Zhu Xinqing Zhao | 2015 | Progress in Natural Science:Materials International2015，25，3： | 5 |
| 11 | AIRIS:Artificial Intelligence Enhanced Signal Processing in Reconfigurable Intelligent Surface Communications显示文摘Reconfigurable intelligent surface(RIS)is an emerging meta-surface that can provide additional communications links through reflecting the signals,and has been recognized as a strong candidate of 6G mobile communications systems.Meanwhile,it has been recently admitted that implementing artificial intelligence(AI)into RIS communications will extensively benefit the reconfiguration capacity and enhance the robustness to complicated transmission environments.Besides the conventional model-driven approaches,AI can also deal with the existing signal processing problems in a data-driven manner via digging the inherent characteristic from the real data.Hence,AI is particularly suitable for the signal processing problems over RIS networks under unideal scenarios like modeling mismatching,insufficient resource,hardware impairment,as well as dynamical transmissions.As one of the earliest survey papers,we will introduce the merging of AI and RIS,called AIRIS,over various signal processing topics,including environmental sensing,channel acquisition,beamforming design,and resource scheduling,etc.We will also discuss the challenges of AIRIS and present some interesting future directions. | Shun Zhang Muye Li Mengnan Jian Yajun Zhao Feifei Gao | 2021 | China Communications2021，18，7： | 4 |
| 12 | α′TypeTi-Nb-Zralloyswithultra-lowYoung′smodulusandhighstrength显示文摘a' phase based Ti-Nb-Zr alloys with low Young's modulus and high strength were prepared,and their microstructure and mechanical properties were characterized.It was revealed that the lattice expansion by Nb and Zr addition as well as the presence of a few of a' martensite might be responsible for the low modulus achieved.Ti-15Nb-9Zr alloy,with ultralow modulus of 39 GPa and high strength of850 MPa,could be a potential candidate for biomedical applications. | Qing Liu Qingkun Meng Shun Guo Xinqing Zhao | 2013 | Progress in Natural Science:Materials International2013，23，6： | 4 |
| 13 | Design and fabrication of a low modulus β-type Ti-Nb-Zr alloy by controlling martensitic transformation显示文摘In this paper, high density of dislocations, grain boundaries and nanometer-scale a precipitates were introduced to a metastable Ti-36Nb-5Zr alloy (wt%) through a thermo-mechanical approach including severe cold rolling and short-time annealing treatment. The martensitic transformation was retarded, and theβphase with low content ofβstabilizers was retained at room temperature after the thermo-mechanical treatment. As a result, both low modulus (57 GPa) and high strength (950 MPa) are obtained.The results indicate that it is a feasible strategy to control martensitic transformation start temperature through micros true ture optimization instead of composition design,with the aim of fabricating low modulusβ-type Ti alloy. | Qing-Kun Meng Yu-Fei Huo Wen Ma Yan-Wei Sui Jin-Yong Zhang Shun Guo Xin-Qing Zhao | 2018 | Rare Metals2018，37，9： | 4 |
| 14 | Oxygen‑Deficient β‑MnO_(2)@Graphene Oxide Cathode for High‑Rate and Long‑Life Aqueous Zinc Ion Batteries显示文摘Recent years have witnessed a booming interest in grid-scale electrochemical energy storage,where much attention has been paid to the aqueous zinc ion batteries(AZIBs).Among various cathode materials for AZIBs,manganese oxides have risen to prominence due to their high energy density and low cost.However,sluggish reaction kinetics and poor cycling stability dictate against their practical application.Herein,we demonstrate the combined use of defect engineering and interfacial optimization that can simultaneously promote rate capability and cycling stability of MnO_(2) cathodes.β-MnO_(2) with abundant oxygen vacancies(VO)and graphene oxide(GO)wrapping is synthesized,in which VO in the bulk accelerate the charge/discharge kinetics while GO on the surfaces inhibits the Mn dissolution.This electrode shows a sustained reversible capacity of~129.6 mAh g^(−1) even after 2000 cycles at a current rate of 4C,outperforming the state-of-the-art MnO_(2)-based cathodes.The superior performance can be rationalized by the direct interaction between surface VO and the GO coating layer,as well as the regulation of structural evolution ofβ-MnO_(2) during cycling.The combinatorial design scheme in this work offers a practical pathway for obtaining high-rate and long-life cathodes for AZIBs. | Shouxiang Ding Mingzheng Zhang Runzhi Qin Jianjun Fang Hengyu Ren Haocong Yi Lele Liu Wenguang Zhao Yang Li Lu Yao Shunning Li Qinghe Zhao Feng Pan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 15 | Influence of annealing temperatures on microstructure evolution and mechanical properties in a low-carbon steel显示文摘Quenching and partitioning (Q&P) heat treatments with different annealing temperatures and fixed initial quenching tem-peratures were applied to cold-rolled low-carbon steel with the initial microstructure of ferrite and pearlite, aiming to gain the same amount of austenite (preset value) before the partitioning stage. The chemical compositions of the material have been specially designed, containing 1.6 wt.% silicon and 0.8 wt.% aluminum to avoid the precipitation of carbides. The micro-structure evolution of the investigated steel was characterized using a dilatometer, an optical microscope, a scanning electron microscope (SEM), an X-ray diffractometer, an electron backscattered diffraction and transmission electron microscope. Consequently, the microstructure of all samples looks quite similar. At the same time, according to SEM micrographs and dilatometer data, there are competitive reactions in Q&P process, such as the precipitation of carbides, the transformation of bainite and the formation of secondary martensite. Thus, the measured austenite is less than the preset values. Mechanical properties of the material were detected by uniaxial tensile tests. The results indicate that the ultimate tensile strength of the four groups of samples is similar, but the total elongation has a significant downward tendency with the increase in annealing temperatures. After annealing at 840 ℃, the steel possesses great ultimate tensile strength of about 1200 MPa and optimum total elongation of about 20.37% with favorable products of strength and elongation of about 24.35 GPa%. | You-hui Jiang Shun Yao Wei Liu Yun Han Su-peng Liu Geng Tian Ai-min Zhao | 2020 | Journal of Iron and Steel Research(International)2020，27，8： | 3 |
| 16 | Soluble Polyimide-reinforced TGDDM and DGEBA Epoxy Composites显示文摘Polyimide(PI)synthesized from aromatic diamine and dianhydrides via two-step poly-condensation method was highly soluble in TGDDM(MY-720)and DGEBA(E-51)at desirable temperature.TGDDM-PI(M-PI)and DGEBA-PI(E-PI)composites within 0.5%-3%PI loading could be prepared without organic solvent.On the cryogenically fractured surfaces of M-PI and E-PI composites,no obvious heterogeneous phase was observed by SEM.The mechanical properties were promoted significantly by PI,especially for impact strength.Adding 2%PI-2W into MY-720 and E-51 composites,the impact strength increased to 21 and 51 kJ/m2,the tensile strength increased by 62%and 19%,and the flexural strength by 18%and 13%,respectively,with slight increases in tensile modulus.These results were related to the promotion in plasticity of composites and changes in fragile→ductile fracture mode.Moreover,Tg and thermal stability of M-PI and E-PI were increased effectively. | Qi Chen Shun Wang Feng Qin Kuan Liu Qian Liu Qing Zhao Xing-Yi Wang Yan-Hong Hu | 2020 | Chinese Journal of Polymer Science2020，38，8： | 3 |
| 17 | A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters显示文摘Urea transporters(UTs)are transmembrane proteins selectively permeable to urea and play an important role in urine concentration.UT-knockout mice exhibit the urea-selective urine-concentrating defect,without affecting electrolyte balance,suggesting that UT-B inhibitors have the potential to be developed as novel diuretics.In this study,we characterized a novel compound 5-ethyl-2-methyl-3-amino-6-methylthieno[2,3-b]pyridine-2,5-dicarboxylate(CB-20)with UT inhibitory activity as novel diuretics with excellent pharmacological properties.This compound was discovered based on high-throughput virtual screening combined with the erythrocyte osmotic lysis assay.Selectivity of UT inhibitors was assayed using transwell chambers.Diuretic activity of the compound was examined in rats and mice using metabolic cages.Pharmacokinetic parameters were detected in rats using LC-MS/MS.Molecular docking was employed to predict the potential binding modes for the CB-20 with human UT-B.This compound dose-dependently inhibited UT-facilitated urea transport with IC50 values at low micromolar levels.It exhibited nearly equal inhibitory activity on both UT-A1 and UT-B.After subcutaneous administration of CB-20,the animals showed polyuria,without electrolyte imbalance and abnormal metabolism.CB-20 possessed a good absorption and rapid clearance in rat plasma.Administration of CB-20 for 5 days did not cause significant morphological abnormality in kidney or liver tissues of rats.Molecular docking showed that CB-20 was positioned near several residues in human UT-B,including Leu364,Val367,and so on.This study provides proof of evidence for the prominent diuretic activity of CB-20 by specifically inhibiting UTs.CB-20 or thienopyridine analogs may be developed as novel diuretics. | Min Li Yan Zhao Shun Zhang Yue Xu Shu-yuan Wang Bo-wen Li Jian-hua Ran Run-tao Li Bao-xue Yang | 2020 | Acta Pharmacologica Sinica2020，41，1： | 3 |
| 18 | Microstructural evolution and mechanical behavior of metastable β-type Ti-25Nb-2Mo-4Sn alloy with high strength and low modulus显示文摘This paper presents a systematic study of newly developed metastable β-type Ti-25Nb-2Mo-4Sn (wt%) alloy with high strength and low elastic modulus, with focus on the microstructural evolution and mechanical behavior associated with aging. The pre-treatment (solution treatment or cold rolling) prior to aging exerts substantial influence on the subsequent aging response including microstructural evolution and mechanical behavior. Even under the same aging treatment, the aging products could be (β+ω), or alternatively (β+α), depending on the pre-treatments. This interesting aging response was discussed on the basis of the mechanism for ω formation. High-density dislocation tangles and grain boundaries induced by severe cold rolling play a key role in hindering the transition from β to isothermal ω, favoring the precipitation of α phase on aging. By aging cold-rolled specimen for short time, superior mechanical properties, i.e. high ultimate strength of ~1113 MPa and low elastic modulus of ~65 GPa, achieved in Ti-25Nb-2Mo-4Sn alloy. The characterization of microstructural evolution and compositional change indicated that the precipitation of fine α does not cause the enrichment of β-stabilizers in β matrix upon a short-time aging, guaranteeing low elastic modulus of the short-time aged specimen. Meanwhile, fine α precipitates as well as dislocations play a crucial part in strengthening, giving rise to its high yield strength and high ultimate tensile strength. | Shun Guo Qingkun Meng Guangyue Liao Liang Hu Xinqing Zhao | 2013 | Progress in Natural Science:Materials International2013，23，2： | 2 |
| 19 | Polycaprolactone/polysaccharide functional composites for lowtemperature fused deposition modelling显示文摘Fused deposition modelling(FDM)is a commonly used 3D printing technology.The development of FDM materials was essential for the product quality of FDM.In this work,a series of polycaprolactone(PCL)-based composites for low-temperature FDM were developed.By melt blending technique,different ratios of starch were added into PCL to improve the performances of FDM,and the printability,tensile strength,rheological properties,crystallization behaviors and biological performances of the composites were studied.The PCL/starch composite had the best performance in FDM process with the starch ratio of 9 ph at 80–90°C.The melting strength and solidification rate of PCL/starch composites were improved.The starch also increased the crystallization temperature,degree of crystallinity and crystallization rate of PCL/starch composites,while had no negative effects on the tensile strength of PCL.Due to the low printing temperature,various kinds of bioactive components were added into PCL/starch composites for preparation of antibacterial and biocompatible materials for FDM.The present work provides a new method to develop novel low-temperature FDM materials with various functions. | Yu-Qing Zhao Ji-Hao Yang Xiaokang Ding Xuejia Ding Shun Duan Fu-Jian Xu | 2020 | Bioactive Materials2020，5，2： | 2 |
| 20 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
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