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| 1 | GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma显示文摘AIM: To evaluate the association between CYPIA1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinorna (ADC) in a high risk area of northwest of France.METHODS: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles, GSTM1 *2/*2 and GSl-l-l*2/*2 null genotypes). A total of 79 esophagealcancer cases and 130 controls were recruited. RESULTS: GSTM2*2/*2 and CYP1A1*1A/*2C genotype frequencies were higher among squamous cell cardnomas at a level close to statistical significance (OR = 1.83, 95% CI0.88-3.83, P= 0.11; OR = 3.03, 95% CI 0.93-9.90, P= 0.07,respectively). For GSTP1 polymorphism, no difference wasfound between controls and cases, whatever their histological status. Lower frequency of GST/-1 deletion was observed in ADC group compared to controls with a statistically significant difference (OR=13.31, 95% CI 1.66-106.92, P<0.01).CONCLUSION: In SCC, our results are consistent with the strong association of this kind of turnout with tobacco exposure. In ADC, our results suggest 3 distinct hypotheses:(1) activation of exogenous procarcinogens, such as small halogenated compounds by GSTTI', (2) contribution of GSTT1 to the inflammatory response of esophageal mucosa, which is known to be a strong risk factor for ADC,possibly through leukotriene synthesis; (3) higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione. | Ahmed Abbas Karine Delvinquière Mathilde Lechevrel Pierre Lebailly Pascal Gauduchon Guy Launoy Fran ois Sichel | 2004 | World Journal of Gastroenterology2004，10，23： | 7 |
| 2 | Amphibia Kupffer cells显示文摘 | Sichel G Scalia M Corsaro C | | 0，，06： | 1 |
| 3 | Inventories and the three phase of the business cycle显示文摘 | Sichel D E | 1994 | Journal of Business and Economic Statistics1994，12，26： | 1 |
| 4 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | Chunming Niu Enid K Sichel Robert Hoch | | 0，，11： | 1 |
| 5 | The amphibian Kupffer cells build and demolish melanosomes:an ultrastructural point of view显示文摘 | Sichel G Scalia M Mondio F | | 0，，05： | 1 |
| 6 | New and Old Models of Business Investment: A Comparison of Forecasting Performance显示文摘 | Oliner S Rudebusch G Sichel D | 1995 | Journal of Money Credit and Banking1995，27，3： | 1 |
| 7 | Fluctuationinduced tunneling conduction in carbon-polyvinylchloride composites 显示文摘 | Sichel E K Gittleman J I | 1978 | Physical Review Letters1978，，18： | 1 |
| 8 | Fluctuation-induced tunneling conduction in carbon-polyvinylchlorIDe composites显示文摘 | Sheng P Sichel E K Gittleman J I | 1978 | Physical Review Letters1978，40，18： | 1 |
| 9 | 2004,“How Fast Do Personal Computers Depreciate?Concepts and new estimates”显示文摘 | Oliner Sichel Doms and Dunn | 2004 | NBER Working Paper2004，，7： | 1 |
| 10 | Measuring capital and technology: An expanded framework 显示文摘 | Corrado C Hulten C Sichel D | 2005 | Studies in In- come and Wealth2005，，65： | 1 |
| 11 | Inventories and the three phases of the business cycle 显示文摘 | Sichel D E | 1994 | Journal of Business & Economic Statistics1994，12，3： | 1 |
| 12 | Fluctuation-induced tunneling conducting in carbon-polyvinylchloride composites 显示文摘 | Sheng P Sichel E K Gittleman J I | 1978 | Phys Rev Lett1978，40，： | 1 |
| 13 | Computers and output growth re-visited:how big is the puzzle- 显示文摘 | OLINER S D Sichel D E | 1994 | Brookings papers on eco-nomic activity1994，19，2： | 1 |
| 14 | Remifentanil- nitroglycerin combination as an anesthetic support for ex utero intrapartum treatment (EXIT) procedure显示文摘 | Ioscovich A Shen O Sichel JY | 2011 | J Clin Anesth2011，23，2： | 1 |
| 15 | Bone conduction experiments in animals:Evidence for a non-osseous mechanism显示文摘 | Freeman S Sichel JY Sohmer H | 2000 | Hearing Research2000，146，： | 1 |
| 16 | High power electro-chemical capacitors based on carbon nanotube electrodes显示文摘 | Niu C Sichel E K Hoch R | 1997 | Appl Phys Lett1997，，： | 1 |
| 17 | Exposure testing of fasteners in preservative treated wood: Gravimetric corrosion rates and corrosion product analyses 显示文摘 | Zelinka S L Sichel R J Stone D S | 2010 | Corrosion Science2010，52，12： | 1 |
| 18 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | NIU C SICHEL E K HOCH R | 1997 | Appl Phys Lett1997，70，11： | 1 |
| 19 | Transport properties of the composite material carbon poly (vinyl chloride)显示文摘 | SICHEL E K GITTLEMAN J I SHENG P | 1978 | Physical Review B1978，18，10： | 1 |
| 20 | A two-step kinetics model for numerical simulation of explosions and detonations in H2-O2 mixtures显示文摘 | SICHEL M TONELLO N A ORAN E S JONES D A | 2002 | Proceedings of the Royal Society of London Series A- Mathematical Physical and Engineering Sciences2002，458，2017： | 1 |
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