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| 1 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 2 | Systematic review: Safety of balloon assisted enteroscopy in Crohn's disease显示文摘AIM To determine the overall and comparative risk of procedure related perforation of balloon assisted enteroscopy(BAE) in Crohn's disease(CD). METHODS Systematic review(PROSPERO #CRD42015016381) of studies reporting on CD patients undergoing BAE. Seventy-three studies reporting on 1812 patients undergoing 2340 BAEs were included. Primary outcome of interest was the overall and comparative risk of procedure related perforation of diagnostic BAE in CD. Secondary outcomes of interest were risk of procedure related perforation of diagnostic double balloon enteroscopy(DBE), risk of procedure related perforation of therapeutic BAE, efficacy of stricture dilation, and clinical utility of endoscopically assessing small bowel disease activity.RESULTS Per procedure perforation rate of diagnostic BAE in CD was 0.15%(95%CI: 0.05-0.45), which was similar to diagnostic BAE for all indications(0.11%; IRR = 1.41, 95%CI: 0.28-4.50). Per procedure perforation rate of diagnostic DBE in CD was 0.12%(95%CI: 0.03-0.44), which was similar to diagnostic DBE for all indications(0.22%; IRR = 0.54, 95%CI: 0.06-0.24). Per procedure perforation rate of therapeutic BAE in CD was 1.74%(95%CI: 0.85-3.55). Eighty-six percentof therapeutic perforations were secondary to stricture dilation. Dilation was attempted in 207 patients and 30% required surgery during median follow-up of 18 months. When diagnostic BAE assessed small bowel disease activity, changes in medical therapy resulted in endoscopic improvement in 77% of patients. CONCLUSION Diagnostic BAE in CD has a similar rate of perforation as diagnostic BAE for all indications and can be safely performed in assessment of mucosal healing. | Ahilan Arulanandan Parambir S Dulai Siddharth Singh William J Sandborn Denise Kalmaz | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 3 | Impact analysis of biodiesel on engine performance: a review 显示文摘 | GAURAV DWIVEDI SIDDHARTH J | 2011 | Renew Sustain Energy Rev2011，15，9： | 1 |
| 4 | Principles of adap- tive noise canceling显示文摘 | Mohamed A A Dean J K Siddharth P | 2004 | Annual Research Journal: Electrical En- gineering Research Experience Undergraduates2004，，2： | 1 |
| 5 | Impact at nalysis of biodiesel on engine performance : A review 显示文摘 | Gaurav Dwivedi J Siddharth A M P Sharm | 2011 | Re1 ble and Sustainable Energy Reviews2011，15，46： | 1 |
| 6 | Prospects of biodiesel from Jatropha in India:a review 显示文摘 | SIDDHARTH J SHARMA M P | 2010 | Renewable and Sustainable Energy Reviews2010，14，2： | 1 |
| 7 | Oxidation stability of blends of Jat- ropba biodiesel with diesel显示文摘 | Siddharth J Sharma M P | 2011 | Fuel2011，90，10： | 1 |
| 8 | Molecular analyses of microbial diversity associated with the Lonar soda lake in India:an impact crater in a basalt area显示文摘 | Wani A A Surakasi V P Siddharth J | 2006 | Research in Microbiology2006，157，10： | 1 |
| 9 | Conversion of the rosin acid fraction of crude tall oil into fuels and chemicals 显示文摘 | ROBERT C SIDDHARTH U WILLIAM A J | 2001 | Energy & Fuels2001，15，5： | 1 |
| 10 | Impact analysis of biodiesel on engine performance-A review显示文摘 | GAURAV D SIDDHARTH J SHARMA M P | 2011 | Re- newable and Sustainable Energy Reviews2011，15，9： | 1 |
| 11 | Molecular typing of fecal eukaryotic microbiota of human infants and their respective mothers显示文摘 | Pandey PK Siddharth J Verma P | 2012 | J Biosci2012，37，2： | 1 |
| 12 | N-polar GaN epitaxy and high electron mobility transistors显示文摘 | Man Hoi Wong Stacia Keller Nidhi Sansaptak Dasgupta Daniel J Denninghoff Seshadri Kolluri David F Brown Jing Lu Nicholas A Fichtenbaum Elaheh Ahmadi Uttam Singisetti Alessandro Chini Siddharth Rajan Steven P DenBaars James S Speck Umesh K Mishra | 2013 | Semiconductor Science and Technology2013，，7： | 1 |
| 13 | Fostering inclusive growth through e - governance embedded rural tele- centers (EGERT) in india 显示文摘 | Gopal N Siddharth J Basavaraj K P | 2012 | Government Information Quarterly2012，29，： | 1 |
| 14 | Conversion of the rosin acid fraction of crude tall oil into fuels and chemicals显示文摘 | ROBERT C SIDDHARTH U WILLIAM A J | 2001 | Energy & Fuels2001，15，5： | 1 |
| 15 | Freeze concentration of sugar cane juice in a jaggery making process显示文摘 | MILIND V R SIDDHARTH K J | 2005 | Applied Thermal Engineering2005，25，1415： | 1 |
| 16 | Impact analysis of biodiesel on engine performance:A review 显示文摘 | Gaurav Dwivedi Siddharth J | 2011 | Renewable and Sustain- able Energy Reviews2011，15，9： | 1 |
| 17 | Teleoperation of a Robot Manipulator Using a Vision Based Human Robot Interface 显示文摘 | Jonathan Kofman Xianghai Wu Timothy J Luu Siddharth Ver- ma | 2005 | IEEE Transactions On Industrial E- lectronics2005，52，5： | 1 |
| 18 | Clinical outcomes of patients with two small hepatocellular carcinomas显示文摘BACKGROUND Management of single small hepatocellular carcinoma(HCC)is straightforward with curative outcomes achieved by locoregional therapy or resection.Liver transplantation is often considered for multiple small or single large HCC.Management of two small HCC whether presenting synchronously or sequentially is less clear.AIM To define the outcomes of patients presenting with two small HCC.METHODS Retrospective review of HCC databases from multiple institutions of patients with either two synchronous or sequential HCC≤3 cm between January 2000 and March 2018.Primary outcomes were overall survival(OS)and transplant-free survival(TFS).RESULTS 104 patients were identified(male n=89).Median age was 63 years(interquartile range 58-67.75)and the most common aetiology of liver disease was hepatitis C(40.4%).59(56.7%)had synchronous HCC and 45(43.3%)had sequential.36 patients died(34.6%)and 25 were transplanted(24.0%).1,3 and 5-year OS was 93.0%,66.1% and 62.3% and 5-year post-transplant survival was 95.8%.1,3 and 5-year TFS was 82.1%,45.85% and 37.8%.When synchronous and sequential groups were compared,OS(1,3 and 5 year synchronous 91.3%,63.8%,61.1%,sequential 95.3%,69.5%,64.6%,P=0.41)was similar but TFS was higher in the sequential group(1,3 and 5 year synchronous 68.5%,37.3% and 29.7%,sequential 93.2%,56.6%,48.5%,P=0.02)though this difference did not remain during multivariate analysis.CONCLUSION TFS in patients presenting with two HCC≤3 cm is poor regardless of the timing of the second tumor.All patients presenting with two small HCC should be considered for transplantation. | Anh Duy Pham Karl Vaz Zaid S Ardalan Marie Sinclair Ross Apostolov Sarah Gardner Ammar Majeed Gauri Mishra Ning Mao Kam Kurvi Patwala Numan Kutaiba Niranjan Arachchi Sally Bell Anouk T Dev John S Lubel Amanda J Nicoll Siddharth Sood William Kemp Stuart K Roberts Michael Fink Adam G Testro Peter W Angus Paul J Gow | 2021 | World Journal of Hepatology2021，13，10： | 0 |
| 19 | Chronic methadone use,poor bowel visualization and failed colonoscopy:A preliminary study显示文摘AIM:To examine effects of chronic methadone usage on bowel visualization,preparation,and repeat colonoscopy.METHODS:In-patient colonoscopy reports from October,2004 to May,2009 for methadone dependent(MD) patients were retrospectively evaluated and compared to matched opioid naive controls(C).Strict criteria were applied to exclude patients with risk factors known to cause constipation or gastric dysmotility.Colonoscopy reports of all eligible patients were analyzed for degree of bowel visualization,assessment of bowel preparation(good,fair,or poor),and whether a repeat colonoscopy was required.Bowel visualization was scored on a 4 point scale based on multiple prior studies:excellent = 1,good = 2,fair = 3,or poor = 4.Analysis of variance(ANOVA) and Pearson χ 2 test were used for data analyses.Subgroup analysis included correlation between methadone dose and colonoscopy outcomes.All variables significantly differing between MD and C groups were included in both univariate and multivariate logistic regression analyses.P values were two sided,and < 0.05 were considered statistically significant.RESULTS:After applying exclusionary criteria,a total of 178 MD patients and 115 C patients underwent a colonoscopy during the designated study period.A total of 67 colonoscopy reports for MD patients and 72 for C were included for data analysis.Age and gender matched controls were randomly selected from this population to serve as controls in a numerically comparable group.The average age for MD patients was 52.2 ± 9.2 years(range:32-72 years) years compared to 54.6 ± 15.5 years(range:20-81 years) for C(P = 0.27).Sixty nine percent of patients in MD and 65% in C group were males(P = 0.67).When evaluating colonoscopy reports for bowel visualization,MD patients had significantly greater percentage of solid stool(i.e.,poor visualization) compared to C(40.3% vs 6.9%,P < 0.001).Poor bowel preparation(35.8% vs 9.7%,P < 0.001) and need for repeat colonoscopy(32.8% vs 12.5%,P = 0.004) were significantly higher in MD group compared to C,respectively.Under univariate analysis,factors significantly associated with MD group were presence of fecal particulate [odds ratio(OR),3.89,95% CI:1.33-11.36,P = 0.01] and solid stool(OR,13.5,95% CI:4.21-43.31,P < 0.001).Fair(OR,3.82,95% CI:1.63-8.96,P = 0.002) and poor(OR,8.10,95% CI:3.05-21.56,P < 0.001) assessment of bowel preparation were more likely to be associated with MD patients.Requirement for repeat colonoscopy was also significant higher in MD group(OR,3.42,95% CI:1.44-8.13,P = 0.01).In the multivariate analyses,the only variable independently associated with MD group was presence of solid stool(OR,7.77,95% CI:1.66-36.47,P = 0.01).Subgroup analysis demonstrated a general trend towards poorer bowel visualization with higher methadone dosage.ANOVA analysis demonstrated that mean methadone dose associated with presence of solid stool(poor visualization) was significantly higher compared to mean dosage for clean colon(excellent visualization,P = 0.02) or for those with liquid stool only(good visualization,P = 0.01).CONCLUSION:Methadone dependence is a risk factor for poor bowel visualization and leads to more repeat colonoscopies.More aggressive bowel preparation may be needed in MD patients. | Siddharth Verma Joshua Fogel David J Beyda Brett Bernstein Vincent Notar-Francesco Smruti R Mohanty | 2012 | World Journal of Gastroenterology2012，18，32： | 0 |
| 20 | Intermodal group-velocity engineering for broadband nonlinear optics显示文摘Interest in the nonlinear properties of multi-mode optical waveguides has seen a recent resurgence on account of the large dimensionality afforded by the platform. The large volume of modes in these waveguides provides a new spatial degree of freedom for phase matching nonlinear optical processes. However, this spatial dimension is quantized, which narrows the conversion bandwidths of intermodal processes and constrains spectral and temporal tailoring of the light. Here we show that by engineering the relative group velocity within the spatial dimension, we can tailor the phase-matching bandwidth of intermodal parametric nonlinearities. We demonstrate group-velocity-tailored parametric nonlinear mixing between higher-order modes in a multi-mode fiber with gain bandwidths that are more than an order of magnitude larger than that previously thought possible for intermodal four-wave mixing. As evidence of the technological utility of this methodology, we seed this process to generate the first high-peak-power wavelength-tunable all-fiber quasi-CW laser in the Ti:sapphire wavelength regime.More generally, with the combination of intermodal interactions, which dramatically expand the phase-matching degrees of freedom for nonlinear optics, and intermodal group-velocity engineering, which enables tailoring of the bandwidth of such interactions, we showcase a platform for nonlinear optics that can be broadband while being wavelength agnostic. | JEFF DEMAS LARS RISH?J XIAO LIU GAUTAM PRABHAKAR SIDDHARTH RAMACHANDRAN | 2019 | Photonics Research2019，7，1： | 0 |
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