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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 3 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 4 | Extreme learning machine: Theory and applications 显示文摘 | HUANG G B ZHU Q Y SIEW C K | 2006 | Neurocomputing2006，70，13： | 1 |
| 5 | Extreme learning machine: theory and applications显示文摘 | Huang G B Zhu Q Y Siew C K | 2006 | Neurocomputing2006，70，12： | 1 |
| 6 | Extreme learning machine: theory and applications显示文摘 | Huang G B Zhu Q Y Siew C K | 2006 | Neurocomputing2006，70，： | 1 |
| 7 | Extreme learning machine: theory and applications显示文摘 | Huang G B Zhu Q Y Siew C K | 2006 | Neurocomputing2006，70，13： | 1 |
| 8 | Universal approxima- tion using incremental constructive feedforward networks with random hidden nodes 显示文摘 | Huang Guangbin Chen Lei Siew C K | 2006 | IEEE Trans on Neural Net- works2006，17，4： | 1 |
| 9 | Extreme learning machine:theory and applications显示文摘 | HUANG G B ZHU Q Y SIEW C K | 2006 | Neurocomputing2006，70，1： | 1 |
| 10 | Extreme learning ma-chine: theory and applications显示文摘 | HUANG Guang-bin ZHU Qin-yu SIEW C K | 2006 | Neurocomputing2006，70，13： | 1 |
| 11 | Extreme learning machine with randomly assigned RBF kernels 显示文摘 | Huang G B Siew C K | 2005 | International Journal of Information Technology2005，11，1： | 1 |
| 12 | Extreme learning machine: theory and applications 显示文摘 | Huang Guangbin Zhu Qinyu Siew C K | 2006 | Neurocomputing2006，70，123： | 1 |
| 13 | Extreme learning machine : Theory and applications 显示文摘 | HUANG G B ZHU Q Y SIEW C K | 2006 | Neurocomputing2006，70，： | 1 |
| 14 | Extreme learning ma- chine: theory and application 显示文摘 | Huang Guangbin Zhu Qinyu Siew C K | 2006 | Neuro Computing2006，70，1： | 1 |
| 15 | Extreme learning machine: Theory and applications显示文摘 | Huang G Zhu Q Siew C | 2006 | Neurocomputing2006，70，123： | 1 |
| 16 | The physicochemical properties of spray-dried watermelon powders显示文摘 | Siew Y Q Ngan K C Peter S | 2007 | Chemical Engineering and Processing2007，46，： | 1 |
| 17 | Extreme Learning Machine: Theory and Applications显示文摘 | H UANG G-B ZHU Q-Y SIEW C K | 2006 | Neurocomputing2006，70，13： | 1 |
| 18 | Universal approximationusing incremental constructive feedforward networks with random hid-den nodes显示文摘 | HUANG Guang-bin CHEN Lei SIEW C K | 2006 | IEEE Trans on Neural Networks2006，17，4： | 1 |
| 19 | Extreme learning machine:theory and applications 显示文摘 | Huang G B Zhu Q Y Siew C K | 2006 | Neurocomputing2006，60，： | 1 |
| 20 | Extreme learning machine: theory and applications 显示文摘 | HUANG G B CHEN L SIEW C K | 2006 | Neurocomputing2006，，70： | 1 |
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