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| 1 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 2 | Angiostatic activity of human plasminogen fragments is highly dependent on glycosylation 显示文摘 | Santos I C Silbiger V N Higuchi D A | 2010 | Cancer Sci2010，101，2： | 1 |
| 3 | Anatomy, mechanics, and pathophysiology of the mitral annulus显示文摘 | Silbiger JJ | 2012 | Am Heart J2012，164，： | 1 |
| 4 | The impact of gender on the progression of chronic renal disease显示文摘 | Silbiger SR Neugarten J | 1995 | Am J Kidney Dis1995，25，： | 1 |
| 5 | Effect of gender on the progression of nondiabetic renal disease: a meta-analysis 显示文摘 | Neugarten J Acharya A Silbiger SR | 2000 | J Am Soc Nephml2000，11，2： | 1 |
| 6 | Gender and human chronic renal disease 显示文摘 | Silbiger S Neugarten J | 2008 | Gend Med2008，5，： | 1 |
| 7 | Effect of gender on the progression of nondiabetic renal diseases meta-analysis显示文摘 | Neugarten J Acharya A Silbiger S R | 2000 | J Am Soc Nephrol2000，11，2： | 1 |
| 8 | Protein kinase CK2 mediates TGFbeta1-stimulated type IV collagen gene transcription and its reversal by estradiol显示文摘 | Zdunek M Silbiger S Lei J | 2001 | Kidney Int2001，60，6： | 1 |
| 9 | Determination of genetic diversity and paternity in greytailed vole ( Microtus canicandus ) by RAPD-PCR 显示文摘 | Gordon D A Lattier D L Silbiger R N Torsetla J Wolff J O Smith M K | 1998 | J Mamm1998，79，： | 1 |
| 10 | Coronary angiographic findings and conventional coronary artery disease risk factors of Indo-Guyanese immigrants with stable angina pectoris and acute coronary syndromes显示文摘 | Silbiger JJ Stein R Trost B | 2012 | Ethnicity and Disease2012，22，1： | 1 |
| 11 | miRNAs as biomarkers of atrial fibrillation显示文摘 | Ananí lia Medeiros Gomes da Silva Vivian Nogueira Silbiger | 2014 | Biomarkers2014，，： | 1 |
| 12 | Effect of gender on the pro-gression of nondiabetic renal disease: a meta-analysis 显示文摘 | Neugarten J Achaya A Silbiger SR | 2000 | J AmSoc Nephrol2000，11，2： | 1 |
| 13 | Gender and human chronic renal disease显示文摘 | Silbiger S Neugarten J | | 0，，： | 1 |
| 14 | Effect of gender on the progression of nondiabetic renal disease: a meta-analysis显示文摘 | Neugarten J Acharya A Silbiger SR | 2000 | J Am Soc Nephrol2000，11，： | 1 |
| 15 | Effect of gender on the progression of nondiabetic renal disease:a meta-analysis显示文摘 | Neugarten J Acharya A Silbiger SR | | 0，，02： | 1 |
| 16 | Effect of gender on the progression of non-diabetic renal disease : a meta-analysis 显示文摘 | Neugarten J Acharya A Silbiger SR | 2000 | J Am Soc Nephrol2000，11，6： | 1 |
| 17 | Protein kinase CK2 mediates TGF-β1stimulated type IV collagen gene transcription and its reversal by estradiol显示文摘 | Zdunek M Silbiger S Lei J | 2001 | Kidney Int2001，60，6： | 1 |
| 18 | miRNAs as biomarkers of atri- al fibrillation显示文摘 | Gomes da Silva AM Silbiger VN | 2014 | Biomarkers2014，19，8： | 1 |
| 19 | Raging hormones:gender and renal disease显示文摘 | Silbiger SR | | 0，，04： | 1 |
| 20 | Estradiol upregulates mesangial cell MMP-2 activity via the transcription factor AP-2 显示文摘 | Guccione M Silbiger S Lei J | 2002 | Am J Physiol Renal Physiol2002，282，1： | 1 |
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