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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 3 | Li- pofuscin- and melanin-related fundus autofluorescence in pa- tients with ABCA 4-associated retinal dystrophies 显示文摘 | Simone K Ulrich K Bernhard HF Britta F Silke W Klaus R | 2009 | Am JOphthcdmol2009，147，8： | 1 |
| 4 | Perfluorooctanoic acid and perfluorooetane suffonate in the sediment of the Roter Main River, Bayreuth, Germany 显示文摘 | BECKER A M SILKE G HARTMUT F | 2008 | Environmental Pollution2008，156，3： | 1 |
| 5 | Mechanical thrombectomy in acute occlusion of the carotid-T : a retrospective single centre study in 51 pa- tients显示文摘 | Daniela F Silke W Miriam I | 2016 | Clin Neumradiol2016，26，1： | 1 |
| 6 | The propagation in metal tubing of ultrasonic wave modes equivalent to Lamb waves 显示文摘 | Silk M G Bainton K F | 1979 | Ultrasonics1979，17，1： | 1 |
| 7 | The propagation in metal tubing of ultrasonce wave modes equivalent to lamb waves显示文摘 | Silk M G Bainton K F | 1979 | Ultrasonics1979，17，1： | 1 |
| 8 | Synthesis and structural characterization of new copper-tellurium clusters:TeBu^n (SiMe3) as a source of RTe^- and Te^2- ligands显示文摘 | John F Corrigan Silke Baiter Dieter Fenske | 1996 | J Chem S Da1996，，5： | 1 |
| 9 | The Propagation in Metal Tubing of Ultrasonic Wave Modes Equivalent to Lamb Waves显示文摘 | SILK M G BAINTON K F | 1979 | Ultrasonics1979，17，1： | 1 |
| 10 | Randomised Trial of Volume-Targeted Ventilation versus Pressure-Limited Ventilation in Acute Respiratory Failure in Prematurely Born Infants显示文摘 | Chowdhury Olie Patel Deena-shefali Hannam Simon Lee Silke Rafferty Gerrard F Peacock Janet L Greenough Anne | 2013 | Neonatology2013，，： | 1 |
| 11 | NKT enhance CD4 + and CD8 + T cell responses to soluble antigen in vivo through direct interaction with dendritic cells显示文摘 | Hermans I F Silk J D Gileadi U | 2003 | J Immunol2003，171，10： | 1 |
| 12 | Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT 显示文摘 | Hermans I F Silk J D Gileadi U | 2007 | J Immunol2007，178，5： | 1 |
| 13 | Short and Long-run Elasticities in US Residential Electricity Demand:A Cointegration Approach显示文摘 | Silk J Joust F | | Energy Economics0，19，： | 1 |
| 14 | Determi- nation of HER2 status using both serum HER2 levels and circulating tumor ceils in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status 显示文摘 | Tanja F Sven B Silke DS | 2007 | Breast Cancer Research Bcr2007，9，5： | 1 |
| 15 | Micro-and nanostructured surface morphology on electrospun polymer fibers显示文摘 | Megelski Silke Stephens Jean S Rabolt John F | 2002 | Macromolecules2002，35，22： | 1 |
| 16 | Polymorphisms within the novel type 2 diabetes risk locus MTNR1 B determine 15-cell funetion显示文摘 | Staiger H Machicao F Silke A | 2008 | PLoS One2008，3，12： | 1 |
| 17 | Acrylmide and glycida-mide:genotoxic effects in V79-cells and hμman blood显示文摘 | Matthiaz B Evelyne F Silke F et a1 | | 0，，： | 1 |
| 18 | Karenia : an exceptional dinoflagellate bloom in western Irish wa- ters, summer 2005 显示文摘 | Silke J O' Beirn F Cronin M | 2005 | Marine Environment and Health Series2005，，： | 1 |
| 19 | Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia 显示文摘 | Silke B Dirk H Katrin F | 2006 | Clinical Neurophysiology2006，117，： | 1 |
| 20 | Sulfonamides in dermatology显示文摘 | SILKE M F PETER E | 2004 | Clinics in Dematology2004，50，6： | 1 |
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