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| 1 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 2 | Experimental behavior of a steel structure under natural fire 显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 3 | Experimental behavior of a steel structure under natural fire显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 4 | Para-metric analysis of the latera-l torsional buckling resistance ofsteel beams in case of fire显示文摘 | P M M Vila Real N Lopes L Sim es da Silva | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 5 | Experimental assessment of the ductility of extended end plate connections显示文摘 | Girao Coelho A M Bijlaard F S K Sim~es da Silva L | 2004 | Engineering Structures2004，，： | 1 |
| 6 | An analytical evaluation of the response of steel joints under bending and axial force显示文摘 | L Sim?es da Silva A.M Gir?o Coelho | 2001 | Computers and Structures2001，，8： | 1 |
| 7 | An analytical evaluation of the response of steel joints under bending and axial force显示文摘 | L Sim?es da Silva A.M Gir?o Coelho | 2001 | Computers and Structures2001，，8： | 1 |
| 8 | Experimental behaviour of a steel structure under naturalfire显示文摘 | Wald F Sim es da Silva L Moore D B Lennon T ChladnáM Santiago A Bene M Borges L | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 9 | Behaviour of flush end-plate beam-to-column joints under bending and axial force 显示文摘 | Luís Sim?es da Silva L R O de Lima P C G das Vellasco S A L de Andrade | 2004 | Steel and Composite Structures2004，4，2： | 1 |
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