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| 1 | Current anti-diabetes mechanisms and clinical trials using Morus alba L.显示文摘Backgrounds:Diabetes mellitus,especially type 2 diabetes,with its fast-rising prevalence,has become a global epidemic.Mulberry(Morus alba L.)leaf has been known to have hypoglycemic effects since ancient times.In Asia mulberry leaf is used as tea to complement the treatment of diabetes mellitus.The methods by which mulberry leaf affects the body and its mechanism when combined with chemical agents have been studied extensively.Conclusions:We summarize the possible mechanisms of the anti-diabetic effects of mulberry leaf based on extraction procedures,in vitro and in vivo experiments,and clinical trials.We also discuss the hypothesis that crosstalk and“critical nodes”may be useful for a deeper molecular understanding of the treatment and prevention of diabetes with mulberry leaf. | Simin Tian Mingmin Tang Baosheng Zhao | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，1： | 4 |
| 2 | Topological electronic states in HfRuP family superconductors显示文摘Based on the first-principles calculations and experimental measurements,we report that the hexagonal phase of ternary transition metal pnictides TT’X(T=Zr,Hf;T’=Ru;X=P,As),which are well-known noncentrosymmetric superconductors with relatively high transition temperatures,host nontrivial bulk topology.Before the superconducting phase transition,we find that HfRuP belongs to a Weyl semimetal phase with 12 pairs of type-II Weyl points,while ZrRuAs,ZrRuP and HfRuAs belong to a topological crystalline insulating phase with trivial Fu-Kane Z_(2) indices but nontrivial mirror Chern numbers.High-quality single crystal samples of the noncentrosymmetric superconductors with these two different topological states have been obtained and the superconductivity is verified experimentally.The wide-range band structures of ZrRuAs have been identified by ARPES and reproduced by theoretical calculations.Combined with intrinsic superconductivity,the nontrivial topology of the normal state may generate unconventional superconductivity in both bulk and surfaces.Our findings could largely inspire the experimental searching for possible topological superconductivity in these compounds. | Yuting Qian Simin Nie Changjiang Yi Lingyuan Kong Chen Fang Tian Qian Hong Ding Youguo Shi Zhijun Wang Hongming Weng Zhong Fang | 2019 | npj Computational Materials2019，，1： | 1 |
| 3 | Intensifying uneven charge distribution via geometric distortion engineering in atomically dispersed M-N_(x)/S sites for efficient oxygen electroreduction显示文摘Fine regulation of geometric structures has great promise to acquire specific electronic structures and improve the catalytic performance of single-atom catalysts,yet it remains a challenge.Herein,a novel seed encapsulation–decomposition strategy is proposed for the geometric distortion engineering and thermal atomization of a series of Cu-N_(x)/S moieties anchored on carbon supports.During pyrolysis,seeds(Cu^(2+),CuO,or Cu_(7)S_(4) nanoparticles)confined in metal organic framework can accommodate single Cu atoms with Cu–N or Cu–S coordination bonds and simultaneously induce C–S or C–N bond cleavage in the second coordination shell of Cu centers,which are identified to manipulate the distortion degree of Cu-N_(x)/S moieties.The severely distorted Cu-N3S molecular structure endows the resultant catalyst with excellent oxygen reduction reaction activity(E_(1/2)=0.885 V)and zinc-air battery performance(peak power density of 210 mW·cm^(−2)),outperforming the asymmetrical and symmetrical Cu-N4 structures.A combined experimental and theoretical study reveals that the geometric distortion of Cu-N_(x)/S moieties creates uneven charge distribution by a unique topological correlation effect,which increases the metal charge and shifts the d-band center toward the Fermi level,thereby optimizing the inter-mediate adsorption energy. | Zhuting Zhang Simin Yang Rui Jiang Tian Sheng Chunfeng Shi Yueguang Chen Leyu Wang | 2022 | Nano Research2022，15，10： | 0 |
| 4 | Mechanisms of high-frequency dinoflagellate blooms of Scrippsiella trochoidea in Daya Bay,South China Sea显示文摘Harmful algal blooms(HABs),such as dinoflagellate blooms,have adverse eff ects on coastal water environments,causing seafood contamination and aquaculture economic losses.Based on historical HAB records data(1983-2017)and phytoplankton data(1982-2008),field investigation and laboratory experiments on frequently bloomed dinoflagellate species,we analyzed the possible mechanisms of high frequency dinoflagellate blooms in Daya Bay,South China Sea.The HAB records data show that the proportion of dinoflagellate blooms increased from 15% before 1994 to 77.27% after 2011.The bloom occurred mostly in summer(57.58%)in Yaling Bay(76.92%).The species inducing dinoflagellate blooms tended to be singular over time,with high proportion of Scrippsiella trochoidea(42.86%-88.88%).Laboratory experiment and field investigation of S.trochoidea bloom showed that this species grew rapidly at 30℃ and 32.1℃(r=0.47,P<0.05),respectively.Results indicate that temperature rise in Yaling Bay was aff ected by nearby nuclear plant effluent,which favored the S.trochoidea bloom.Coincidently,nearly 70% of S.trochoidea blooms occurred in about 7 days after local spring tide and strong wind(wind velocity>7 m/s),which disturbed the resting cysts in the sediment and bring them into surface layer.Taking into account of environmental parameters,algae source,and atmospheric conditions,the probable mechanism of S.trochoidea bloom could be explained.The cysts were resuspended by the spring tide or strong wind,germinated at the bottom layer,reproduced rapidly at higher temperature,and then aggregated in the inner bay(Yaling Bay),resulting the frequent S.trochoidea bloom.Considering the influences of global warming and human activities,it should be taken more attention that dinoflagellate blooms might increase along the coastal waters. | Yuan TIAN Simin HU Xianzhi LIN Hui HUANG Xingyu SONG Yan YAN Xuedong XIE Tao LI Sheng LIU | 2021 | Journal of Oceanology and Limnology2021，39，4： | 0 |
| 5 | Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19显示文摘Dear Editor,The emerging severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant Omicron has rapidly replaced the Delta variant and presents a huge challenge to public health and health care infrastructure.Cytokine-driven hyperinflammation is the leading cause of a series of COVID-19 clinical symptoms.1 Our research attempted to discover an anti-inflammatory or anti-viral small molecule agent capable of treating COVID-19 hyperinflammation. | Ning Lu Tingxuan Gu Xueli Tian Simin Zhao Guoguo Jin Fredimoses Mangaladoss Yan Qiao Kangdong Liu Ran Zhao Zigang Dong | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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