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| 1 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 2 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 3 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 4 | Partitioning sparse matrices with eigenvectors of graphs显示文摘 | Pothen A Simon H D Liou K P | 1990 | SIAM Journal on Matrix Analysis and Applications1990，11，3： | 1 |
| 5 | TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘 | Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C | 2009 | Int J Immunopathol Pharmacol2009，22，4： | 1 |
| 6 | Residual-effeeted homogeneous charge compression ignition at a low compression ratio using exhaust reinduetion显示文摘 | Citon P A Simon A J Jerdes J C | 2003 | Int J Engine Res2003，4，3： | 1 |
| 7 | Erroneous measure- ment of haemodynamic parameters by PICCO(TM) monitor in a crit- ically ill patient with renal replacement therapy: a case report 显示文摘 | Martinez Simon A Monedero P Cacho Asenjo E | 2006 | Crit Care2006，10，2： | 1 |
| 8 | Extending and implementing the stable model semantics显示文摘 | Simons P Niemel(A)a I Soininen T | | 0，，1： | 1 |
| 9 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 10 | Pre - B - cell colo- ny - enhancing factor as a potential novel biomarker in acute lung in- jury显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 11 | Symmetry-based re- sistance as a novel means of lower limb rehabilitation 显示文摘 | Simon A M Brent G R Ferris D P | 2007 | Journal of Biomechanics2007，40，6： | 1 |
| 12 | Shear bond testing of concrete repairs 显示文摘 | Simon A Peter R Youguang P | 1999 | Cement and Concrete Research1999，29，7： | 1 |
| 13 | Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice显示文摘 | Simons J P McClenaghan M Clark A J | 1987 | Nature1987，328，： | 1 |
| 14 | Pre-B-cell colony-enhancing factor as a potential novelbiomarker in acute lung injury 显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J RespirCrit Care Med2005，171，4： | 1 |
| 15 | Reduction and internal fixation of displaced intra-articular calcaneal fractures with a locking nail:a prospective study of sixty nine cases显示文摘 | Simon P Goldzak M Eschler A | 2015 | International Orthopaedics2015，39，10： | 1 |
| 16 | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: A randomized phase II trial 显示文摘 | Pascher A De Simone P Pratschke J | 2015 | Am J Transplantation2015，15，5： | 1 |
| 17 | Characterization of as- phaltenes and resins from problematic Mexican crude oils 显示文摘 | Eduardo B G Marcela E P Simon I A | 2001 | Petro- leum Sci Technol2001，19，34： | 1 |
| 18 | Partitioning sparse ma- trices with eigenvectors of graphs 显示文摘 | Pothen A Simon H Liou K P | 1990 | SLAM J Matrix Anal Appl1990，11，3： | 1 |
| 19 | 显示文摘 | DOCKER M P HODGSON A SIMONS J P | 1986 | Faraday Discuss: Chem Soc1986，82，： | 1 |
| 20 | A review of copper cyanide recovery technologies for the cyanidation of copper containing gold ores 显示文摘 | DAI X SIMONS A BREUER P | 2012 | Minerals Engineering2012，25，1： | 1 |
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