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| 1 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 2 | Fecal microbiota in sensitized wheezy and non-sensitized non-wheezy children: a nested case-control study 显示文摘 | Murray CS Tannock GW Simon MA | 2005 | Clin Exp Allergy2005，35，： | 1 |
| 3 | Dexamathason prevent cerebral infarction without affecting cerebral blood flow in neonatal rats显示文摘 | Tour UI Simone CS Barks JDE | 1993 | Stroke1993，24，： | 1 |
| 4 | Permissive hypereapnia with high-frequency oscillatory ventilation and one-lung isolation for intraoperafive management of lung resection in a patient with multiple bronchopleural fistulae显示文摘 | Tietjen CS Simon BA Helfaer MA | 1997 | J Clin Anesth1997，9，1： | 1 |
| 5 | Dexamathason prevent cerebralinfraction without affecting cerebral blood flow in neonatal rats显示文摘 | Tour UI Simone CS Barks JDE | 1993 | Stroke1993，24，： | 1 |
| 6 | A new arenavirus in a cluster of fatal transplant-associated diseases 显示文摘 | Palacios G Druce J DU L Tran T Birch C Colan S Quan PL Hui J Marshall J Simons JF Eqholmn M Paddock CD Shich WJ Goldsmith CS Zaki SR Catton M Lipkin WI | 2008 | N Engl J Med2008，358，10： | 1 |
| 7 | Dexamethasone prevents cerebral infarction without affecting cerebral blood flow in neonatal rats显示文摘 | Simone CS Barks JD | 1993 | Stroke1993，24，3： | 1 |
| 8 | Pemissive hypercapnia with high-frequency oscillatory ventilation and one-lung iso- lation for intraoperative management of lung resection in a patient with multiple bronchopleural firstulate 显示文摘 | Tiejen CS Simon BA Hefaer MA | 1997 | J Cin Anesth1997，9，1： | 1 |
| 9 | Targeting Plasmodium PI4K to eliminate malaria 显示文摘 | McNamara CW Lee MC Lim CS Lim SH Roland J Nagle A Simon O Leung BK Chatterjee AK McCormack SL Manary MJ Zeeman AM Dechering KJ Kumar TR Henrich PP Gagaring K Ibanez M Kato N Kuhen KL Fischli C Rottmann M Plouffe DM Bursulaya B Meister S Rameh L Trappe J Haasen D Timmerman M Sauerwein RW Suwanarusk R Russell B Renia L Nosten F Tully DC Kocken CH Glynne RJ Bodenreider C Fidock DA Diagana TT Winzeler EA | 2013 | Nature2013，504，7479： | 1 |
| 10 | Suberoylanilide hydroxamic acid(SAHA)potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines显示文摘 | Dietrich CS 3rd Greenberg VL De Simone CP Modesitt SC van Nagell JR Craven R | 2010 | Gynecol Oncol2010，116，1： | 1 |
| 11 | Glucocorticoid prevention of neonatal hypoxic-ischemic damage:Role of hyperglycemia and antioxidant enzymed 显示文摘 | Simone CS Arellena R Tanswdl K Post M | 1993 | Brain Res1993，604，12： | 1 |
| 12 | The LRRK2 I2012T, G2019S, and I2020T Mutations are Rare in Taiwanese Patients with Sporadic Parkinson's Disease 显示文摘 | Lu CS Simons EJ Wu-Chou YH | 2005 | Parkinsonism Relat Disord(S1353-8020)2005，11，6： | 1 |
| 13 | Analysis of left ventrieular sys- tolic function using midwall mechanics in patients 60 years of age with hypertensive heart disease and heart failure显示文摘 | Vinch CS Aurigemma GP Simon HU | 2005 | Am J Cardiol2005，96，9： | 1 |
| 14 | Biochemicaland functional characterization of a recombinant GTPase,Rab5,and two of its mutants显示文摘 | Simon H Jack CS Shaobin L | 1995 | JBC1995，270，10： | 1 |
| 15 | The LRRK2 I2012T,G2019S,and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease显示文摘 | Lu CS Simons EJ Wu-Chou YH | 2005 | Parkinsonism Relat Disord2005，11，8： | 1 |
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