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您的检索式：作者名="Simons S.H.P."
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| 1 | 接受人工通气新生儿中吗啡对动脉血压的影响显示文摘Objective: To study the effects of continuous morphine infusion on arterial bl ood pressure in ventilated neonates. Design: Blinded randomised placebo controll ed trial. Setting: Level III neonatal intensive care unit in two centres. Patients: A total of 144 ventilated neonates. Inclusion criteria were postnatal age < 3 days, ventilation < 8 hours, and indwelling arterial line. Exclusion criteria were severe asphyxia, severe intraventricular haemorrhage, major congenital anomalies, neu romuscular blockers. Intervention: Arterial blood pressure was measured before t he start and during the first 48 hours of masked infusion of drug (morphine/plac ebo; 100 μg/kg+10 μg/kg/h). Outcome measures: Arterial blood pressure and blo od pressure variability. Results: There were no significant differences in overa ll mean arterial blood pressure between the morphine group (median (interquartil e range) 36 mm Hg (6) and the placebo group (38 mm Hg (6)) (P=0.11). Although si gnificantly more morphine treated patients (70%) showed hypotension than the pl acebo group (47%) (P=0.004), the use of volume expanders and vasopressor drugs was not significantly different (morphine group, 44%; placebo group, 48%; P=0. 87), indicating the limited clinical significance of this side effect. Blood pre ssure variability was not influenced by routine morphine analgesia (P=0.81) or a dditional morphine (P=0.80). Patients with and without intraventricular haemorrh age showed no differences in blood pressure (Mann-Whitney U test 1953; P=0.14) or incidence of hypotension (χ2 test 1.16; df 1; P=0.28). Conclusions: Overall arterial blood pressure, use of inotropes, and blood pressure variability were n ot influenced by morphine infusion. Therefore the clinical impact of hypotension as a side effect of low dosemorphine treatment in neonates is negligible. | Simons S.H.P. Roofthooft D.W.E. Van Dijk M. D. Tibboel 郭战宏 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，5： | 0 |
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