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	题名	作者	年代	出处	被引量
1	Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH.	Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong	2022	Stroke & Vascular Neurology2022，7，1：	3
2	Network - based approach to on -line cursive script recognition 显示文摘	SIN B K HA J Y OH S C	1999	IEEE Transaction on System Man and Cybernetics-Part B:Cybernetics1999，29，2：	2
3	Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘	Schaefer N Sinning C Standop J		0，，01：	2
4	Gastric stump carcinoma-epidemiology and current concepts in palhogenesis and treatment 显示文摘	Sinning C Schaefer N Standop J	2007	Eur J Surg Oncol2007，33，2：	1
5	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant tochemotherapy显示文摘	Rosas C Sinning M Ferreira A	2014	Biol Res2014，47，1：	1
6	Pathophysiology,diagnosis and prognostic implications of endothelial dysfunction显示文摘	Munzel T Sinning C Post F	2008	Ann Med2008，40，3：	1
7	Assessment of the air quality in indoor car parks显示文摘	Wong Y C Sin D W M Yeung L L	2002	Indoor and Built Enviment2002，11，3：	1
8	Antitumor therapeutic effects of salmonella typhimurium containing Flt3 ligand expression plasmids in melanoma-bearing mouse 显示文摘	YOON W S CHOI W C SIN J I	2007	Biotechnol Lett2007，29，4：	1
9	Drugs their targets and the nature and number of drug targets显示文摘	IMMING P SINNING C MEYER A	2006	Nat Rev Drug Discov2006，5，10：	1
10	Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry显示文摘	SIN D W M WONG Y C IPB A C		0，，03：	1
11	Trends of ambient carbonyl compounds in the urban environment of Hong Kong显示文摘	Sin D W M Wong Y C Louie P K K	2001	Atmospheric Environment2001，35，34：	1
12	The genesis of friction显示文摘	SUH N P SIN H C	1981	Wear1981，69，1：	1
13	Determination of quinoxaline-2-carboxylic acid, the major metabolite of carbadox, in porcine liver by isotope dilution gas chromatography-electron capture negative ionization mass spectrometry显示文摘	Sin D W M Chung L P K Lai M M C	2004	Anal Chim Acta2004，508，2：	1
14	Antisense approaches for elucidating ranavirus gene function in an infected fish cell line显示文摘	Whitley D S Sample R C Sinning A R	2011	Dev Comp Immunol2011，35，9：	1
15	Nonnasal Lymphoma expressing the natural killer cell marker CD56:A clinico pathologic study of 49 cases of an uncommon aggressive neoplasm显示文摘	CHAN J K SIN V C WONG K F	1997	Blood1997，89，：	1
16	A new one-step synthesis method for coating multi-walled carbon nanotubes with cuprous oxide nanoparticles 显示文摘	Reddy K R Sin B C Yoo C H	2008	Scripta Mater2008，58，11：	1
17	A DNA vaccine against foot-and-mouth disease elicits an immune response in swine which is enhanced by co-administration with interleukin-2显示文摘	Wong H T Cheng S C Sin F W	2002	Vaccine2002，20，2122：	1
18	Determination of quinoxaline-2-carboxylic acid, the major metabolite of carbadox, in porcine liver by isotope dilution gas chromatography - electron capture negative ionization mass spectrometry显示文摘	SIN D W M S CHUNG L P K LAI M M C	2004	Anal Chem Acta2004，508，：	1
19	Treatment andprognosis of gastric stump carcinoma in comparison with primaryproximal gastric cancer显示文摘	SCHAEFER N SINNING C STANDOP J	2007	Am J Surg2007，194，1：	1
20	Relationship Marketing Orientation:Scale Development and Cross-cuhural Validation显示文摘	SIN L Y M TSE A C B YAU O H M	2005	Journal of Business Research2005，58，2：	1

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