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| 1 | 一项在欧洲和中国进行的新型胃泌素释放肽前体(ProGRP)免疫检测多中心评估研究显示文摘背景在欧洲和中国进行Elecsys?胃泌素释放肽前体(ProGRP)免疫检测的多中心评估研究。方法在欧洲的3个中心和中国的2个中心,在肺癌中,通过不精密度、稳定性、方法学比较和鉴别诊断能力来评价该检测法。结果 5个分析物浓度的中间不精密度范围为变异系数:2.2%-6.0%。在不同储存条件下,血浆和血清样本均显示出良好的稳定性。在血浆中Elecsys?和ARCHITECT检测(斜率1.02,截距-2.72 pg/m L)之间表现出良好的相关性。同时,Elecsys?检测在血清和血浆样本之间表现出良好的相关性(斜率0.93,截距2.35 pg/m L;相关系数0.97)。ProGRP作为不受种族、年龄、性别或吸烟史相关影响的检测手段,可鉴别小细胞和非小细胞肺癌(NSCLC);截断值为84pg/m L时,曲线下面积为0.90,95%CI:0.87-0.93;敏感性为78.3%,特异性为95%。ProGRP浓度中位数在良性病变(38pg/m L)、其他恶性肿瘤(40 pg/m L)或NSCLC(39 pg/m L)中较低,而在3期以上慢性肾脏疾病中浓度较高(>100pg/m L)。结论 Elecsys?ProGRP检测在血清和血浆中稳定性增加,较现有检测法明显更具优势。ProGRP检测在中国的首次评价在不同种族中显示出相当的鉴别能力。 | Catharina M.KORSE Stefan HOLDENRIEDER Xiuyi ZHI Xiaotong ZAHNG Ling QIU Andrea GEISTANGER Marcus-Rene LISY Birgit WEHNL Daan van den BROEK José M.ESCUDERO Jens STANDOP Mu HU Rafael MOLINA | 2017 | 中国肺癌杂志2017，20，8： | 7 |
| 2 | Gastric stump carcinoma – Epidemiology and current concepts in pathogenesis and treatment显示文摘 | C. Sinning N. Schaefer J. Standop A. Hirner M. Wolff | 2006 | European Journal of Surgical Oncology2006，，2： | 5 |
| 3 | Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘 | Nico Schaefer Christoph Sinning Jens Standop Marcus Overhaus Andreas Hirner Martin Wolff | 2007 | The American Journal of Surgery2007，，1： | 2 |
| 4 | Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘 | Schaefer N Sinning C Standop J | | 0，，01： | 2 |
| 5 | Gastric stump carcinoma-epidemiology and current concepts in palhogenesis and treatment 显示文摘 | Sinning C Schaefer N Standop J | 2007 | Eur J Surg Oncol2007，33，2： | 1 |
| 6 | Treatment andprognosis of gastric stump carcinoma in comparison with primaryproximal gastric cancer显示文摘 | SCHAEFER N SINNING C STANDOP J | 2007 | Am J Surg2007，194，1： | 1 |
| 7 | 5-Lipoxygenase and Leukotriene B 4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue显示文摘 | René Hennig Xian-Zhong Ding Wei-Gang Tong Matthias B. Schneider Jens Standop Helmut Friess Markus W. Büchler Parviz M. Pour Thomas E. Adrian | 2002 | The American Journal of Pathology2002，，2： | 1 |
| 8 | Gastric stump carcinoma epidemiology and current concepts in pathogenesis and treatment(review) 显示文摘 | Sinning C Schaefer N Standop J | 2007 | EJSO2007，33，： | 1 |
| 9 | Expression of nerve growth factors in pancreastic neural tissue and pancreatic cancer显示文摘 | Schneider M B Standop J Ulrich A | 2001 | J Histochem Cytochem2001，49，10： | 1 |
| 10 | Gastric stump carcinoma-epidemiology and current concepts in pathogenesis and treatment显示文摘 | Sinning C Schaefer N Standop J | 2007 | Eur J Surg Oncol2007，33，2： | 1 |
| 11 | Inhibition of neuropilin-1by RNA-interference and its angiostatic potential in the treatment of hepatocellular carcinoma显示文摘 | Raskopf E Vogt A Standop J | 2010 | Z Gastroenterol2010，48，1： | 1 |
| 12 | Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘 | Schaefer N Sinning C Standop J | 2007 | Am J Surg2007，194，1： | 1 |
| 13 | Gastric stump carcinoma-Epidemiology and current concepts in pathogenesis and treatment显示文摘 | Sinning C Schaefer N Standop J | | 0，，02： | 1 |
| 14 | Operative re-intervention following pancreatic head resection: indications and outcome显示文摘 | Standop J Glowka T Schmitz V | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 15 | Treatment and prognosis of gastric stump carcinoma in comparison with proximal gastric cancer显示文摘 | Schaefer N Sinning C Standop J | 2007 | Am J Surg2007，94，1： | 1 |
| 16 | Inhibition of neuropilin-1 by RNA-interferenee and its angiostatie potential in the treatment of hepatocellular carcinoma 显示文摘 | Raskopf E Vogt A Standop J | 2010 | Z Gastroenterol2010，48，1： | 1 |
| 17 | Gastric stump carcinoma-epidemiology and current concepts in pathogenesis and treatment显示文摘 | Sinning C Schaefer N Standop J | 2007 | Eur J Surg Oncol2007，33，2： | 1 |
| 18 | Operative re - interven- tion following pancreatic head resection: indications and outcome 显示文摘 | Standop J Glowka T Schmitz V | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 19 | Gastric stump carcinoma-epidemiology and current concepts in pathogenesis and treatment显示文摘 | Sinning C Schaefer N Standop J | 2007 | Eur J Surg Oncol2007，33，2： | 1 |
| 20 | Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘 | Schaefer N Sinning C Standop J el al | 2007 | Am J Surg2007，194，1： | 1 |
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