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| 1 | CD74 is a survival receptor on colon epithelial cells显示文摘AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analyzed by (quantitative) qRT-PCR, RTPCR, Western blotting and FACS. RESULTS: CD74 was found to be expressed on normalCEC. Stimulation of CD74 by MIF induced a signaling cascade leading to up-regulation of Bcl-2 expression, resulting in a signif icant increased survival of CEC. CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression. | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar | 2010 | World Journal of Gastroenterology2010，16，26： | 9 |
| 2 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracelluler matrix显示文摘 | Poltorak Z Cohen T Sivan R Kandelis Y | 1997 | Biol Chem1997，272，11： | 1 |
| 3 | VEGF145 ,a secreted vascular endothelial growth factor isoform that binds to extracellularmatrix 显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 4 | VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matri 显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | Biol Chem1997，14，11： | 1 |
| 5 | Meconium Ileus Caused by Mutations in GUCY2C , Encoding the CFTR-Activating Guanylate Cyclase 2C显示文摘 | Hila Romi Idan Cohen Daniella Landau Suliman Alkrinawi Baruch Yerushalmi Reli Hershkovitz Nitza Newman-Heiman Garry R. Cutting Rivka Ofir Sara Sivan Ohad S. Birk | 2012 | The American Journal of Human Genetics2012，，5： | 1 |
| 6 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 7 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Cohen T Sivan R | 1997 | J Biol Chem1997，272，： | 1 |
| 8 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 9 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，： | 1 |
| 10 | VEGF145 ,a secreted vas- cular endothelial growth {actor isoform that binds to extracel lular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，71： | 1 |
| 11 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracelluar matrix显示文摘 | Polterak Z Cohen T Sivan R etal | 1997 | J Biol Chem1997，272，11： | 1 |
| 12 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | POLTORAK Z COHEN T SIVAN R | 1997 | J Biol Chem1997，272，11： | 1 |
| 13 | VEGF145, a secreted VEGF isoform that binds to extra cellular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，172，： | 1 |
| 14 | Serial in utero ultrasonographic measurements of the fetal thyroid: a new complementary tool in the management of maternal hyperthyroidism in pregnancy显示文摘 | Cohen O Pinhas-Hamiel O Sivan E | 2003 | Prenat Diagn2003，23，9： | 1 |
| 15 | VEGF145, a secreted vascular endothelial growth factor isoformthat binds to extracellular matrix 显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 16 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracellar matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 17 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix 显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 18 | VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
| 19 | VEGF145 a secreted vascular endothelial growth factor isoform that binds toextracellalarmatrix显示文摘 | Poltorak I Cohen T Sivan R | 1997 | J Biol chem1997，272，： | 1 |
| 20 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracellular matrix显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
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