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| 1 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 2 | New Catalysts for Coal to Ethylene Glycol显示文摘 | Zhiqiao Wang Zhongning Xu Siyan Peng Zhangfeng Zhou Pengbin Pan Lin Lin Yeyan Qin Guocong Guo Yuangen Yao | 2017 | Chinese Journal of Chemistry2017，35，6： | 6 |
| 3 | 满足运载火箭测控需求的Ka频段CTDRSS终端技术显示文摘To meet the application requirements for a Ka-band space-based TT&C terminal for a launch vehicle,this paper proposes the implementation scheme of a space-based TT&C terminal,analyzes and solves the miniaturized design of equipment and the key technology for high-efficiency heat dissipation.The phased array antenna test shows that without external heat dissipation measures,the phased array antenna can work for a long time to meet the working requirements of launch vehicle,which has been verified in the LM-8 mission,and has wide engineering application prospects. | LIAO Yanjie SONG Rui GONG Changhui ZHANG Siyan ZHOU Lin | 2021 | Aerospace China2021，22，2： | 0 |
| 4 | RNF219 interacts with CCR4-NOT in regulating stem cell differentiation显示文摘Regulation of RNA stability plays a crucial role in gene expression control.Deadenylation is the initial rate-limiting step for the majority of RNA decay events.Here,we show that RING finger protein 219(RNF219)interacts with the CCR4-NOT deadenylase complex.RNF219-CCR4-NOT exhibits deadenylation activity in vitro.RNA-seq analyses identify some of the 2-cell-specific genes and the neuronal genes significantly downregulated upon RNF219 knockdown,while upregulated after depletion of the CCR4-NOT subunit CNOTIO in mouse embryonic stem(ES)cells.RNF219 depletion leads to impaired neuronal lineage commitment during ES cell differentiation.Our study suggests that RNF219 is a novel interacting partner of CCR4-NOT and required for maintenance of ES cell pluripotency. | Hao Du Chen Chen Yan Wang Yang Yang Zhuanzhuan Che Xiaoxu Liu Siyan Meng Chenghao Guo Manman Xu Haitong Fang Fengchao Wang Chengqi Lin Zhuojuan Luo | 2020 | Journal of Molecular Cell Biology2020，12，11： | 0 |
| 5 | On‑Ramp Merging for Highway Autonomous Driving:An Application of a New Safety Indicator in Deep Reinforcement Learning显示文摘This paper proposes an improved decision-making method based on deep reinforcement learning to address on-ramp merging challenges in highway autonomous driving.A novel safety indicator,time difference to merging(TDTM),is introduced,which is used in conjunction with the classic time to collision(TTC)indicator to evaluate driving safety and assist the merging vehicle in finding a suitable gap in traffic,thereby enhancing driving safety.The training of an autonomous driving agent is performed using the Deep Deterministic Policy Gradient(DDPG)algorithm.An action-masking mechanism is deployed to prevent unsafe actions during the policy exploration phase.The proposed DDPG+TDTM+TTC solution is tested in on-ramp merging scenarios with different driving speeds in SUMO and achieves a success rate of 99.96%without significantly impacting traffic efficiency on the main road.The results demonstrate that DDPG+TDTM+TTC achieved a higher on-ramp merging success rate of 99.96%compared to DDPG+TTC and DDPG. | Guofa Li Weiyan Zhou Siyan Lin Shen Li Xingda Qu | 2023 | Automotive Innovation2023，6，3： | 0 |
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