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| 1 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 2 | Elevated cortisol level in blood of patients with unstable coronary disease and acute myocardialinfarction--new approach显示文摘 | Domański L Pietrzak-Nowacka M Szmatloch E | 2000 | Pol Arch Med Wewn2000，104，6： | 1 |
| 3 | Sensitivity to disinfectants of methicillin resistant staphylococcus aureus strains (MRSA) and gentamicin resistant strains显示文摘 | Wi(s)niewska K Galiński J Piechowicz L | | 0，，3： | 1 |
| 4 | Homocysteine, heat shock proteins, genistein and vitamins in ischemic stroke-pathogenic and therapeutic implications显示文摘 | Banecka-Majkutewicz Z Sawula W Kadziński L | | 0，，04： | 1 |
| 5 | Effects of support on hydrogenadsorption/desorption on nickel显示文摘 | Znak L Zielin ski J | 2008 | Applied Catalysis A:General2008，334，12： | 1 |
| 6 | 查看详情显示文摘 | H aber J M atachow ski L Pamin K | | 0，，： | 1 |
| 7 | The effect of anterior cruciate ligament trauma and bracing on knee proprioception显示文摘 | Beynnon BD Ryder Ski Konradsen L | 1999 | Am J Sports Med1999，27，2： | 1 |
| 8 | The basis function regression in pharmaceutical analysis theory and example of appllcation显示文摘 | Komsta L Skibin Ski B Parylo M | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，47，： | 1 |
| 9 | Interfacial characterization of Cu/diamond composites prepared by powder metallurgy for heat sink application 显示文摘 | Schubert T Ciupiski L Zieliński W | 2008 | Scripta Materialia2008，58，： | 1 |
| 10 | Adjustments in gait symmetry with walking speed in trans-femoral and trans-tibial amputees显示文摘 | Nolan L Wit A Dudzi(n)ski K | | 0，，02： | 1 |
| 11 | Aortic stiffness and valvular calcifications in patients with end-stage renal disease 显示文摘 | Zapolski T Wysokin ski A Janicka L | 2008 | PolArch Med Wewn2008，118，3： | 1 |
| 12 | Phenotyping male infertility in the mouse: how to get the most out of a 'non- performer'显示文摘 | Borg C L Wo|ski K M Gibbs G M et a| | 2010 | Human reproduction update2010，16，2： | 1 |
| 13 | Outcomes of primary coronary angioplasty and angioplasty after initial thrombolysis in the treatment of 374 consecutive patients with acute myocardial infarction显示文摘 | Poloński L Gasior M Wasilewski J | 2003 | Am Heart J2003，145，5： | 1 |
| 14 | Application of a linear synthetic polymer to im- proved the properties of cellulose fibers made by the NMMO process 显示文摘 | Ewandow Ski Z L | 2002 | J of Applied Polym Sci2002，83，13： | 1 |
| 15 | Methio- nine and cystine requirements of slow - and fast - feathering broiler males from three to six weeks of age显示文摘 | Kalinow SKI A Moran E T JR Wyatt C L | 2003 | Poultry Science2003，，82： | 1 |
| 16 | Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the { beta }-casein gene in mammary epithelial cells显示文摘 | BUSER A C GASS-HANDEL E K WYSZOMIER- SKI S L | 2007 | Mol Endoerinol2007，21，1： | 1 |
| 17 | Ablation of severe drug-resis- tant tachyarrhythmia during pregnancy显示文摘 | Szumowski L Szufladowicz E Orczykow- ski M | 2010 | J CardiovascElectrophysiol2010，21，8： | 1 |
| 18 | Multi-criteria classification:a new scheme for application of dominance-based decision rules显示文摘 | B(l)aszczyński J Greco S S(l)owiński R | 2007 | European Journal of Operational Research2007，181，3： | 1 |
| 19 | Increased interleukin-18 content and angiogenic activity of sera from diabetic (type 2) patients with background retinopathy显示文摘 | SKOPIN′SKI P ROGALA E DUDA KRO′L B | 2005 | J Diabetes Complicat2005，19，6： | 1 |
| 20 | Rough sets theory for multicriteria decision analysis显示文摘 | Greco S Matarazzo B S(l)owiński R | 2002 | European Journal of Operational Research2002，129，1： | 1 |
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