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| 1 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 2 | Neuroblastoma:reportof a 21-year experience 显示文摘 | Massad M Slim MS Mansour A | 1986 | J Pediatr Surg1986，21，： | 1 |
| 3 | Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats显示文摘 | Slim R M Robertson D G Albassam M | 2002 | Toxicol Appl Pharmacol2002，183，2： | 1 |
| 4 | Characterization of a novel Vip3-type from Bacillus thuringiensis and evidence of its presence on a large plasmid显示文摘 | Lobna A M Slim To | 2005 | FEMS Microbiology Letters2005，，24： | 1 |
| 5 | An acoustic- structural interaction modelling for the evaluation of a gearbox-radiated noise 显示文摘 | Slim Abbes M Bouaziz S Chaari F | 2008 | International Journal of Me- chanical Sciences2008，50，3： | 1 |
| 6 | Efficient photochemical water splitting by a chemically modified n-TiO~显示文摘 | Khan SLIM AI-Shahry M | 2002 | Science2002，297，： | 1 |
| 7 | Consensus guidelines forenhanced recovery after gastrectomy: Enhanced Recovery After Surgery ( ERAS (~) Society recommendations 显示文摘 | Mortensen K Nilsson M Slim K | 2014 | Br J Surg2014，101，10： | 1 |
| 8 | Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats显示文摘 | Slim RM Robertson DG Albassam M | 2002 | Toxicol Appl Pharmacol2002，183，2： | 1 |
| 9 | Diagnostic imaging in the follow-up of nonoperative management of splenic trauma in children显示文摘 | Minarik L Slim M Rachlin S | 2002 | Pediatr Surg Int2002，18，56： | 1 |
| 10 | Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats显示文摘 | Slim RM Roberstson DG Ajbassam M | 2003 | Toxicol Appl Res2003，183，2： | 1 |
| 11 | The incidence of phlebitis with intravenous amiodarone at guideline dose recommendations显示文摘 | Slim A M Roth J E Duffy B | 2007 | Military Medicine2007，172，： | 1 |
| 12 | Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery ( ERAS ~) Society recommendations 显示文摘 | Mortensen K Nilsson M Slim K | 2014 | Br J Surg2014，101，10： | 1 |
| 13 | Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesionsin rats 显示文摘 | Slim RM Roberstson DG Ajbassam M | 2003 | Toxicol Appl Res2003，183，2： | 1 |
| 14 | The role of radiology in nerve function impairment and its musculoskeletal complications in leprosy 显示文摘 | Slim FJ Faber WR Maas M | 2009 | Lepr Rev2009，80，4： | 1 |
| 15 | Familial imperforate anus显示文摘 | Soussou I Der Kaloustian V Slim M | | 0，，04： | 1 |
| 16 | Consensus guide- lines for enhanced recovery after gastrectomy: Enhanced Re- covery After Surgery ( ERAS) Society recommendations 显示文摘 | Mortensen K Nilsson M Slim K | 2014 | Br J Surg2014，101，10： | 1 |
| 17 | Hepatobiliary and Pancreatic: Peliosis hepatis associated with multiple myeloma显示文摘 | R Slim N Hachem V Smayra C Yaghi F Daniel J Boujaoude K Honein R Sayegh M Ghosn | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 18 | Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats 显示文摘 | Robertson DG Albassam M | 2002 | Toxicol Appl Pharmacol2002，183，2： | 1 |
| 19 | Peginterferonalfa-2a plus ribavirin for HIV-HCV genotype 1co-infected patients: a randomized international trial显示文摘 | Rodriguez-Torres M Slim J Bhatti L et a1 | 2012 | HIV Clin Trials2012，13，3： | 1 |
| 20 | Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery(ERAS) Society recommendations显示文摘 | Mortensen K Nilsson M Slim K | 2014 | Br J Surg2014，101，10： | 1 |
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