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| 1 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 2 | Iterated Galerkin method for eigenvalue problem 显示文摘 | SLOAN I H | 1976 | SIAM J Numer Anal1976，13，： | 1 |
| 3 | Cathepsin B and its role (s) in cancer progression显示文摘 | POGORSKI I SLOANE B F | 2003 | Biochem Soc Symp2003，70，： | 1 |
| 4 | The Galerkin method for integral equations of the first kind with loga- rithmic kernel: theorem显示文摘 | Sloan I H Spence A | 1988 | IMA J Numer Anal1988，8，1： | 1 |
| 5 | Accrual Reliability, Earnings Persistence and Stock Prices显示文摘 | Richardson S A R G Sloan M T Sohrmn I Tuna | 2005 | Jour- nal of Accounting and Economics2005，，39： | 1 |
| 6 | Piecewise continuous collocation for integral equations显示文摘 | Atkinson K E Graham I Sloan I | 1983 | SIAM Numer Anal1983，20，： | 1 |
| 7 | Cathepsin B and tumor proteolysis : contribution of the tumor microenvironment显示文摘 | SLOANE BF YAN S PODGORSKI I | 2005 | Semin Cancer Biol2005，15，2： | 1 |
| 8 | Disability and the La- bour Market: An Analysis of British Males显示文摘 | Kidd M P Sloane P J Ferko I | 2000 | Journal of Health Economics2000，19，6： | 1 |
| 9 | Piecewise continuous collocation for integral equations显示文摘 | Atkinson K E Graham I Sloan I | 1983 | SIAM J Numer Anal1983，20，： | 1 |
| 10 | Constructive polynomial approxhnation on the sphere显示文摘 | Sloan I H Womersely R S | 2000 | J Appr Theory2000，103，： | 1 |
| 11 | Cathepsin B and its role (s) in cancer progression显示文摘 | PODGORSKI I SLOANE B F | 2003 | Bioehem Soc Syrup2003，70，： | 1 |
| 12 | The Effect of Handwriting on Teachers' Grading of High School Essays显示文摘 | SLOAN C McGINNIS I | 1982 | Jour- nal of the Association for the Study of Perception1982，，2： | 1 |
| 13 | A quadrature based approach to improving the collocation method显示文摘 | Sloan I H | 1988 | Numerische Mathematik1988，54，1： | 1 |
| 14 | A fourth-order cubic spliue method for linear second-order two-point boundary-value problems显示文摘 | Sloan I H | 1993 | IMA Journal of Numerical Analysis1993，13，4： | 1 |
| 15 | Gas hydrate deposition on a cold surface in water-saturated gas systems显示文摘 | RAO I KOH C A SLOAN E D | 2013 | Industrial & Engineering Chemistry Research2013，52，18： | 1 |
| 16 | Labour Market Segmentation: A Local Labour Market Analysis Using Alternative Approaches 显示文摘 | Sloane P J Murphy P D Theodossiou I White M | 1993 | Applied Economics1993，25，5： | 1 |
| 17 | Cathepsin B and its role (s) in cancer progression显示文摘 | Sloane BF | 2003 | Biochem Soc Syrup2003，70，： | 1 |
| 18 | Accrual reliability,earnings persistence,and stock prices显示文摘 | Richardson SA Sloan RG Soliman MT Tuna I | | 0，，03： | 1 |
| 19 | Cathepsin B and tumor proteolysis:contribution of the tumor microenvironment显示文摘 | Sloane BF Yan S Podgorski I | 2005 | Semin Cancer Biol2005，15，2： | 1 |
| 20 | On the numerical solution of a logarithmic integral equation of the first kind for the Helmholtz equation显示文摘 | Kress R Sloan I H | 1993 | Numer Math1993，66，： | 1 |
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