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| 1 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 2 | 6min步行试验中不同指令对行走距离的影响显示文摘6min步行试验(6-minwalktest,6MWT)作为测定心肺功能的一种方法,一直以使患者走的尽可能远为目标,然而,特定的步行指令对患者6MWT测定的影响尚不清楚。方法:纳入肺动脉高压(pulmonaryarterialhypertension,PAH)、特发性肺间质纤维化(idiopathicpulmonaryfibrosis,IPF)和其他类型的间质性肺疾病(interstitiallungdisease,ILD)患者, | 刘莉 叶鹏 Weir NA Brown AW Shlobin OA Smith MA Reffett T Battle E Ahmad S Nathan SD | 2014 | 中华高血压杂志2014，22，2： | 13 |
| 3 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 4 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 5 | Neglected Rural Public Health Issue:The Case of Intestinal Roundworms显示文摘Despite increasing institutional and financial support,certain public health issues are still neglected by the Chinese Government.The present paper examines the soil-transmitted helminth(STH)infection and reinfection rates by conducting a survey on 1724 children in Guizhou Province,China.Our results indicate that 37.5 percent of children had been infected with one or more of the three types of tested STH.However,only 50.4 percent of children reported having taken deworming medicine during the 18-month period before the survey.Of those who reported being dewormed,34.6 percent tested positive for STH infections.Poverty and number of siblings are significantly and positively correlated with infection and reinfection,and parental education is significantly and negatively correlated with infection and reinfection.Given the ineffectiveness of treatment in these areas to date,for anthelmintic campaigns to actually succeed,China must pay more attention to locallevel incentives to improve children's health. | Linxiu Zhang Yingping Cai Xiaobing Wang Xiaochen Ma Alexis Medina D.Scott Smith Scott Rozelle | 2013 | China & World Economy2013，21，3： | 2 |
| 6 | Stimulus dependence of neuronal correlation in primary visual cortex of the macaque 显示文摘 | Kohn A Smith MA | 2005 | J Neurosci2005，25，14： | 1 |
| 7 | Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 Caucasian women 显示文摘 | Rodin A Murby B Smith MA Caleffi M Fentiman I Chapman MG Fogelman I | 1990 | Bone1990，，11： | 1 |
| 8 | Greenhouse gases and other airborne pollutants from household stoves in China:a database for emission factors显示文摘 | Smith K R Ma Y | 2000 | Atmospheric Environment2000，34，26： | 1 |
| 9 | Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity显示文摘 | Goulder MA | 2001 | J Fam Pract2001，，50： | 1 |
| 10 | Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons显示文摘 | Wang X Perry G Smith MA | 2010 | Neurodegener Dis2010，7，13： | 1 |
| 11 | Stress and glucocortieoids affect the expression of brain-- derived neurotrophic factor and neurotrophin--3 mRNAs in the hippocampus 显示文摘 | Smith MA Makino S Kvetnansky R | 1995 | J Neurosci1995，15，31： | 1 |
| 12 | Prognosis and outcomes of patients with community-acquired pneumonia显示文摘 | Fine MJ Smith MA Carson CA | 1996 | JAMA1996，275，： | 1 |
| 13 | Effect of atropine on heart rate turbulence显示文摘 | Marine JE Watanabe MA Smith TW | 2002 | AM J Cardiol2002，89，6： | 1 |
| 14 | Juvenile and adult rat neuromuscular junctions:Density,distribution,and morphology显示文摘 | Ma J Smith BP Smith TL | 2002 | Muscle Nerve2002，26，： | 1 |
| 15 | Basic fibrob last growth factor enhances the coupling of intimal hyperplasia andproliferation of vasa vasorum in injured rat arteries 显示文摘 | EDELMAN ER NUGEN MA SMITH LT | 1992 | J Clin Invest1992，89，2： | 1 |
| 16 | Resonant crystal bandgap metamaterials in microwave regime and their exotic amplification of evanescent waves显示文摘 | Ruopeng Liu Tie Jun Off Bo Zhao Xian Qi Lin Hui Feng Ma Da Huang D R Smith | 2007 | Appl Phys Lett2007，90，09： | 1 |
| 17 | Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction 显示文摘 | Huffman JC Smith FA Blais MA | 2008 | Psyehosomaties2008，49，4： | 1 |
| 18 | The level of response to alcohol in daughters of alccoholics and controls 显示文摘 | Eng MY Schuckit MA Smith TL | 2005 | Drug Alcohol Depend2005，79，1： | 1 |
| 19 | Vascular oxidative stress in Alzheimer disease显示文摘 | Zhu X Smith MA Honda K | 2007 | J Neurol Sci2007，257，12： | 1 |
| 20 | Brain and other central nervous system cancers: recent trends in incidence and mortality 显示文摘 | Legler JM Ries LA Smith MA | 1999 | J Nail Cancer Inst1999，91，23： | 1 |
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