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| 1 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 2 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 3 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 4 | Myocardialnecrosis induced by temporary occlusion of coronary atery in the dog 显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，70，1： | 1 |
| 5 | Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants 显示文摘 | BRAGA O SMYTHE G A FEITZ A J S | 2005 | Environ Sci Technol2005，39，9： | 1 |
| 6 | Nitric oxide production and heart failure显示文摘 | Winlaw D S Smythe G A Keogh A M | 1993 | Lancet1993，341，2： | 1 |
| 7 | Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants 显示文摘 | Braga O Smythe G A Schafer A I | 2005 | Environmental Science Technology2005，39，9： | 1 |
| 8 | An inventory based analy- sis of Canada's managed forest carbon dynamics, 1990 to 2008 显示文摘 | Stinson G Kurz W A Smyth C E | 2011 | Global Change Biology2011，17，6： | 1 |
| 9 | Glucocorticoid pretreatment induces eytokine over expression and nuclear facto-β activation in macrophages显示文摘 | Smyth G P Stapleton P P Freeman T A | 2004 | J Surg Res2004，11，： | 1 |
| 10 | Study of the white-rot fungal degradation of selected phthalocyanine dyes by capillary electrophoresis and liquid chromatography显示文摘 | A Conneely W F Smyth G McMullan | 2002 | Analytica Chimica Acta2002，451，2： | 1 |
| 11 | Nitric oxide production and heart failure显示文摘 | Winlaw D S Smythe G A Keogh A M | 1995 | The Lancet1995，345，11： | 1 |
| 12 | Assessment of hydroxyl radical generation and radical scavenging activity of Chinese medicinal herbs using GC-MS显示文摘 | Wang X Smythe G A | 2003 | Redox report2003，8，4： | 1 |
| 13 | Combining mass spectrometry based electronic nose, visible-near infrared spectroscopy and chemometrics to assess the sensory properties of Australian Riesling wines显示文摘 | Cozzolino D Smyth H E Lattey K A Cynkar W Janik L Damberges R G Francis I L Gishen M | 2006 | Analytica Chimica Acta2006，563，： | 1 |
| 14 | Prevalence of netB among some clini- cal isolates of Clostridium perfringens from animals in the United States 显示文摘 | Martain T G Smyth J A | 2009 | Vet Microbiol2009，136，： | 1 |
| 15 | Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，6，70： | 1 |
| 16 | Specific analysis of nitrate and nitrite by gas chromatography/mass spec- trometry显示文摘 | SMYTHE G A MATANOVIC G | 2002 | Methods Enzymol2002，359，1： | 1 |
| 17 | Molecular characterization of the Smyth chicken sublines and their parental controls by RFLP and DNA fingerprint analysis显示文摘 | SREEKUMAR G P SMYTH J R Jr PONCEDELEON F A | 2001 | Poult Sci2001，80，1： | 1 |
| 18 | Exact and approximate reml for heteroscedastic regression显示文摘 | Smyth G K Huele A F and Verbyla A P | 2001 | Statistical Modeling2001，1，： | 1 |
| 19 | Adjusted likelihood methods for modeling dispersion in generalized linear models显示文摘 | Smyth G K and Verbyla A P | 1999 | Environmetrics1999，10，： | 1 |
| 20 | Steroid estrogens in ocean sediments显示文摘 | Braga O Smythe G A Schafer A I | 2004 | Chemosphere2004，61，6： | 1 |
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