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| 1 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction显示文摘 | Sobajima S Shimer AL Chadderdon RC | 2005 | Spine J2005，5，： | 1 |
| 3 | Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction显示文摘 | Satoshi Sobajima Adam L. Shimer Robert C. Chadderdon John F. Kompel Joseph S. Kim Lars G. Gilbertson James D. Kang | 2005 | The Spine Journal2005，，： | 1 |
| 4 | Neonatal sudden death due to LegloneUa pneumonia associated with water birth in a domestic spa bath 显示文摘 | Nagai T Sobajima H Iwasa M | 2003 | J Clin Microbiol2003，41，： | 1 |
| 5 | Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction显示文摘 | SOBAJIMA S SHIMER A L CHADDERDON R C | 2005 | Spine J2005，5，1： | 1 |
| 6 | Quantitative analysis of geue expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction显示文摘 | Shimer AL Chadderdon RC | 2005 | Spine J2005，5，1： | 1 |
| 7 | A Slowly Progressive and Reproducible Animal Model of Intervertebral Disc Degeneration Characterized by MRI, X-Ray, and Histology显示文摘 | Satoshi Sobajima John F. Kompel Joseph S. Kim Corey J. Wallach Douglas D. Robertson Molly T. Vogt James D. Kang Lars G. Gilbertson | 2005 | Spine2005，，： | 1 |
| 8 | Study of the light-trapping effects of textured ZnO:Al/glass structure TCO for improving photoeurrent of a-Si:H solar cells显示文摘 | SOBAJIMA Y KATO S MATSUURA T | 2007 | Journal of Materials Sciences Materials in Electronics2007，18，1： | 1 |
| 9 | Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy显示文摘 | Shikano M Sobajima H Yoshikawa H | 2000 | Nephron2000，85，1： | 1 |
| 10 | Gene therapy for degenerative disc disease 显示文摘 | Sobajima S Kim JS Gilbertson LG | 2004 | Gene Ther2004，11，4： | 1 |
| 11 | Maternity blues and attachment to children in mothers of full-term normal infants显示文摘 | Nagata M Nagai Y Sobajima H | 2000 | Acta Psychiatr Scand2000，101，： | 1 |
| 12 | Feasibility of stem cell therapy for intervertebral disc degeneration显示文摘 | Sobajima S Shimer A Kim J | 2004 | Spine J2004，4，： | 1 |
| 13 | Gene transfer of the catabolic inhi-bitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs显示文摘 | Wallach CJ Sobajima S Watanabe Y | 2003 | Spine2003，28，20： | 1 |
| 14 | Safety assessment of intradiscal gene therapy Ⅱ 显示文摘 | LevicofI EA Kim JS Sobajima S | 2008 | Spine2008，33，14： | 1 |
| 15 | Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropa-thy显示文摘 | Shikano M Sobajima H Yoshikawa H | | 0，，01： | 1 |
| 16 | Implication for melatonin and its receptor in the spinal deformities of hereditary Lordoscoliotic Rabbits 显示文摘 | Sobajima S Kin A Bata I | 2003 | Spine2003，28，6： | 1 |
| 17 | High mobility group (HMG) non - histone chromosomal proteins HMGI and HMG2 are significant target antigens of perinuclear anti - neutrophil cytoplasmic antibodies in autoimmune hepatitis 显示文摘 | Sobajima J Ozaki S Uesugi H | 1999 | Gut1999，44，6： | 1 |
| 18 | Chromosome numbers of Diospyros kald Cultivars显示文摘 | Zhuang D H Kitajima A Ishida M Sobajima Y | 1990 | Journal of Japanese Society Horticulture Science1990，59，2： | 1 |
| 19 | Gene transfer of the catabolic inhibitor TIMP-I increases measured proteoglycans in cells from degenerated human intervertebral discs显示文摘 | Wallach CJ Sobajima S Watanabe Y | 2003 | Spine2003，28，20： | 1 |
| 20 | Expression of thymidine phosphorylase in primary colorectal cancer and liver metastasis- relationship between mRNA levels in cancer cells and protein levels in cancerous tissue显示文摘 | lshibashi K Sobajima J Ishiguro T | 2009 | Gan To Kagaku Ryoho2009，36，3： | 1 |
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