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| 1 | Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord显示文摘The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen score.Mast cells(MC)were identified by histochemistry and quantified.In EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle group.KF also reduced the number of testicular MC compared to vehicle group.Similarly,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial edema.Focal signs of inflammation and fibrosis of seminiferous tubular walls were also observed.In contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated animals.In conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT models.The results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss. | Diego Moreno Cristian M Sobarzo Livia Lustig Marcelo G Rodriguez Pena Vanesa Anabella Guazzone | 2020 | Asian Journal of Andrology2020，22，1： | 3 |
| 2 | Molecular identification and quantification of bacteria from endodontic infections using real-time polymerase chain reaction显示文摘 | Blome B Braun A Sobarzo V | 2008 | Oral Microbiol Immunol2008，23，5： | 1 |
| 3 | Coastal upwelling process on a continental shelf limited by submarine canyons, Concepcion, central Chile显示文摘 | SOBARZO M DJURFELDT L | 2004 | Journal of Geophysical Research2004，109，12： | 1 |
| 4 | Effects of di(2-ethylhexyl)phthalate on gap and tight junction protein expression in the testis of prepubertal rats 显示文摘 | SOBARZO C M LUSTIG L PONZIO R | 2009 | Microsc Res Tech2009，72，11： | 1 |
| 5 | Effects of di (2- ethylhexyl) phthalate on gap and tight junction protein ex- pression in the testis of prepubertal rats显示文摘 | Sobarzo CM Lustig L Ponzio R | 2009 | Microsc Res Tech2009，72，11： | 1 |
| 6 | Persistent immune responses after Ebola virus infection 显示文摘 | Sobarzo A Sobarzo A Ochayon DE | 2013 | N Engl J Med2013，369，5： | 1 |
| 7 | Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis 显示文摘 | Sobarzo CM Lustig L Ponzio R | 2006 | Reprod Toxicol2006，22，1： | 1 |
| 8 | Effect of di-(2-ethylhexyl)phthalate on N-cadherin and catenin protein expression in rat testis显示文摘 | Sobarzo C M Lustig L Ponzio R | 2006 | Reproductive Toxicology2006，22，： | 1 |
| 9 | Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats显示文摘 | Sobarzo C M Lustig L Ponzio R | | 0，，11： | 1 |
| 10 | Effect of di - (2 -ethylhexyl) phthalate on N -cadherin and catenin protein expression in rat testis 显示文摘 | SOBARZO C M LUSTIG L PONZIO R | 2006 | Reprod Toxicol2006，22，1： | 1 |
| 11 | The influence of winds and tides in the formation of circulation layers in a bay a cade study: Concepcion Bay, Chile显示文摘 | Sobarzo M B Figueroa D Arcos D R | 1997 | Estuarine Coastal and Shelf Science1997，45，： | 1 |
| 12 | Matrix metallopro- teinase expression and activity in trophoblast-decidual tis- sues at organogenesis in CF-1 mouse显示文摘 | Fontana V Coll TA Sobarzo CM et a/ | 2012 | J Mol Histol2012，43，5： | 1 |
| 13 | Sperm quality in mice acutely treated with parathion显示文摘Aim: To investigate the toxic effect of a single injection of the organopbospborous agropesticide, parathion, on spermatogenesis in immature male mice. Methods: Seven-day old mice received a single injection of parathion intraperitoneally at a dose of 1/3 LD50. The epididymal sperm count, sperm morphology and chromatin thermal stability were analyzed 28 and 50 days after injection. Results: Sperm counts were decreased and teratozoospermia and thermal denaturation of DNA increased after parathion injection. Sperm parameters were changed to a greater extent in younger animals, denoting a nigher lability of spermatogenic process at its beginning. The damages could recover a long time after parathion administration. Conclusion: Organopbospborous agropesticides are testicular toxicants, eliciting reversible cytotoxic and cytogenetic alterations in germ cells. | Cristian Sobarzo Eduardo Bustos-Obregon | 2000 | Asian Journal of Andrology2000，2，2： | 1 |
| 14 | Molecular identification and quantification of bacteria from endodontic infections using real-time polymerase chain reaction显示文摘 | Blome B Braun A Sobarzo V | 2008 | Oral Microbiol Immunol2008，23，5： | 1 |
| 15 | Profile and persistence of the virus specific neutralizing humoral immune response in human survivors of Sudan ebolavirus (Gulu) 显示文摘 | Sobarzo A Groseth A Dolnik O | 2013 | J Infect Dis2013，208，2： | 1 |
| 16 | Controlled release of nerve growth factor from a polymeric implant 显示文摘 | Powell EM Sobarzo MR Saltzman WM | 1990 | Brain Res1990，515，12： | 1 |
| 17 | Persistent immune responses after Ebola virus infection显示文摘 | Sobarzo A Ochayon DE Lutwama JJ | 2013 | New Engl J Med2013，369，5： | 1 |
| 18 | Profile and persistence of the virus-specific neutralizing humoral immune response in human survivors of Sudan ebola virus (Gulu) 显示文摘 | Sobarzo A Groseth A Dolnik O | 2013 | J Infect Dis2013，208，2： | 1 |
| 19 | Upwelling of Subsurface Water into the Rim of the Biobio Submarine Canyon as a Response to Surface Winds 显示文摘 | Sobarzo M Figueroa M Djurfeldt L | 2001 | Continental Shelf Research2001，21，3： | 1 |
| 20 | Loss of occludin expres- sion and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interieukin 6 on Sertoli cell tight junctions 显示文摘 | P6rez CV Sobarzo CM Jacobo PV | 2012 | Biol Reprod2012，87，5： | 1 |
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