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		题名	作者	年代	出处	被引量
	1	Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis.	Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa	2019	World Journal of Gastroenterology2019，25，1：	7
	2	Drosophila p53 preserves genomic stability by regulating cell death显示文摘	Sogame N Kim M Abrams JM	2003	Proc Natl Acad Sci2003，100，：	1
	3	Solid pseudopapillary tumor as a possible cause of acute pancreatitis 显示文摘	Sakagami J Kataoka K Sogame Y	2004	JOP2004，5，5：	1
	4	Increased QT dispersion in patients with alcoholic pancreatitis显示文摘	Sakagami J Kataoka K Sogame Y	2004	Pancreas2004，28，4：	1
	5	Disposition of 14C pazufloxacin mesilate in rats and mice显示文摘	Hayakawa H Takano Y Sogame Y	1999	Japan J Chemother1999，47，1：	1
	6	Solid pseudopapillary tumor as a possible cause of acute pancreatitis 显示文摘	Sakagami J Kataoka K Sogame Y	2004	JOP2004，5，5：	1
	7	Temporal changes in the incidence and 30-day mortality associated with bacteremia in hospitalized patients from 1992 through 2006: a population-based cohort study显示文摘	Sogam'd M Ncrgam'd M Dethlefsen C	2011	Clin Infect Dis2011，52，1：	1
	8	Incidence and risk factors for postoperative pulmonary complications in elective intracranial surgery显示文摘	Sogame LC Vidotto MC Jardim JR	2008	J Neurosurg2008，109，2：	1
	9	Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membrane显示文摘	Kobayashi K Sogame Y Hara H	1990	J Bio Chem1990，265，：	1
	10	Drosophila p53 preserves ge- nomic stability by regulating cell death显示文摘	Sogame N Kim M Abrams J M	2003	Proe Natl Acad SCi2003，100，8：	1
	11	Solid pseudopapillary tumor as a possible cause of acute pancreatitis显示文摘	Sakagami J Kataoka K Sogame Y	2004	JOP2004，5，5：	1
	12	Disposition of 14C-pazufloxacin mesilate in rats and mice 显示文摘	Hayakawa H Takano Y Sogame Y	1999	Japan J Chemother1999，47，1：	1
	13	A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes显示文摘	Sogame Y Kitamura A Yabuki M	2009	Biopharm Drug Dispos2009，30，8：	1
	14	Solid pseudopapillary tumor as a possible cause of acute pancreatitis显示文摘	Sakagami J Kataoka K Sogame Y	2004	JOP2004，5，5：	1
	15	Drosophila p53 preserves genomic stability by regulating cell death 显示文摘	Sogame N Kim M Abrams JM	2003	Proc Natl Acad Sci U S A2003，100，8：	1
	16	Solid pseudopapillary tumor as a possible cause of acute pancreatitis显示文摘	SAKAGAMI J KATAOKA K SOGAME Y	2004	JOP2004，5，5：	1
	17	The prediction of extubation success of postoperative neurosurgieal patients using frequency tidal volume ratios显示文摘	Vidotto MC Sogame LC Caleiolari CC	2008	Neurocrit Care2008，9，1：	1
	18	Solid pseudopapillary tumor as a possible cause of acute pancreatitis显示文摘	Sakagami J Kataoka K Sogame Y	2004	J Pancreas2004，5，5：	1
	19	Implications of extuba- tion failure and prolonged mechanical ventilation in the postopera- tive period following elective intracranial surgery 显示文摘	Vidotto MC Sogame LC Gazzotti MR	2011	Braz J Med Biol Res2011，44，12：	1

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