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| 1 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 2 | Deficiency of macrophage migration inhibitory factor gene delays healing of the medial collateral ligament: A biomechanical and biological study显示文摘 | Soichiro Kitayama Shin Onodera Eiji Kondo Takumi Kobayashi Shin Miyatake Nobuto Kitamura Harukazu Tohyama Kazunori Yasuda | 2010 | Journal of Biomechanics2010，，3： | 1 |
| 3 | Water-resistant organic thermoelectric generator with >10μW output显示文摘Flexible p–n thermoelectric generator(TEG)technology has rapidly advanced with power enhancement and size reduction.To achieve a stable power supply and highly efficient energy conversion,absolute chemical stability of n-type materials is essential to ensuring large temperature differences between device terminals and ambient stability.With the aim of improving the long-term stability of the n-type operation of carbon nanotubes(CNTs)in air and water,this study uses cationic surfactants,such as octylene-1,8-bis(dimethyldodecylammonium bromide)(12-8-12),a gemini surfactant,to stabilize the nanotubes in a coating,which retains the n-doped state for more than 28 days after exposure to air and water in experiments.TEGs with 10 p-n units of 12-8-12/CNT(n-type)and sodium dodecylbenzene sulfonate/CNT(p-type)layers are manufactured,and their water stability is evaluated.The initial maximum output of 16.1μW(75 K temperature difference)is retained after water immersion for 40 days without using a sealant to prevent TEG module degradation.The excellent stability of these CNT-based TEGs makes them suitable for underwater applications,such as battery-free health monitoring and information gathering systems,and facilitates the development of soft electronics. | Shinichi Hata Kanto Maeshiro Misaki Shiraishi Soichiro Yasuda Yuta Shiozaki Koudai Kametani Yukou Du Yukihide Shiraishi Naoki Toshima | 2023 | Carbon Energy2023，5，4： | 0 |
| 4 | Green Route for Fabrication of Water-Treatable Thermoelectric Generators显示文摘Since future energy harvesting technologies require stable supply and high-efficiency energy conversion,there is an increasing demand for high-performance organic thermoelectric generators(TEGs)based on waterproof thermoelectric materials.The poor stability of n-type organic semiconductors in air and water has proved a roadblock in the development of reliable thermoelectric power generators.We developed a simple green route for preparing n-type carbon nanotubes(CNTs)by doping with cationic surfactants and fabricated films of the doped CNTs using only aqueous media.The thermoelectric properties of the CNT films were investigated in detail.The nanotubes doped using a cationic surfactant(cetyltrimethylammonium chloride(CTAC))retained an n-doped state for at least 28 days when exposed to water and air,indicating higher stability than that for contemporary CNT-based thermoelectric materials.The wrapping of the surfactant molecules around the CNTs is responsible for blocking oxygen and water from attacking the CNT walls,thus,extending the lifetime of the n-doped state of the CNTs.We also fabricated thermoelectric power conversion modules comprising CTAC-doped(n-type)and sodium dodecylbenzenesulfonate-(SDBS-)doped(p-type)CNTs and tested their stabilities in water.The modules retained 80±2:4%of their initial maximum output power(at a temperature difference of 75℃)after being submerged in water for 30 days,even without any sealing fills to prevent device degradation.The remarkable stability of our CNT-based modules can enable the development of reliable soft electronics for underwater applications. | Shinichi Hata Misaki Shiraishi Soichiro Yasuda Gergely Juhasz Yukou Du Yukihide Shiraishi Naoki Toshima | 2022 | Energy Material Advances2022，，1： | 0 |
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