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| 1 | Tuning the mechanosensitivity of a BK channel by changing the linker length显示文摘一些大传导力的 Ca2+ 和激活电压的 K+( 放射性元素) 隧道被膜段激活。然而, BK 隧道的门 mechano 的机制仍然不好被理解。以前的研究导致了连接器门戒指建筑群作为一个被动弹簧工作的建议,力量由细胞内部的 Ca2+ 产生了到门打开隧道的 transducing。这提出膜段是否也被传给 mechanosensitive (MS ) 的门的问题经由连接器门建筑群的放射性元素隧道。学习这,我们在激活段的放射性元素隧道(SAKCaC ) 改变了连接器长度,并且在结果的变异的隧道的 gating 上检验了膜段的效果。弄短而扩大连接器,增加的连接器减少了,隧道 mechanosensitivity 当面并且当细胞内部的 Ca2+ 不在时。然而,电压和 Ca2+ 敏感没被膜段显著地改变。而且, SAKCaC 在相对高的细胞内部的 Ca2+ 集中或膜去极对膜段变得不太敏感。这些观察建议一旦隧道在开状态的符合构造,在春天的紧张部分被释放,膜段是不太有效的。我们的结果与那膜段经由 MS 放射性元素隧道的连接器门戒指建筑群被转移到门的想法一致。 | Hucheng Zhao | 2008 | Cell Research2008，18，8： | 6 |
| 2 | Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice显示文摘This study investigated the effects of progesterone(P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice.The administration of P4(4 mg/kg) for 3 consecutive days beginning on the 0-2 nd day after the first BrdU-injection(BrdU-D0-2) produced an approximately twofold increase in the number of 28-and 56-day-old BrdU(+) cells in comparison to the controls,whereas it did not alter the number of 24 /48-h-old BrdU(+) cells.P4 preferentially promoted the survival of newborn neurons when administered at BrdU-D5-7,but not at BrdU-D10-12 and BrdU-D15-17.Androstenedione(Ad),testosterone(TE),or estradiol(E2) at the same-dose of P4,when administered at BrdU-D0-2,could not replicate the effect of P4,while the inhibition of 5 alpha-reductase by finasteride did not affect the P4-action,indicating that the P4-effect is exerted by P4 itself but not by its metabolites.On the other hand,the P4R antagonist RU486 partially suppressed the P4-effect,while inhibitors for Src,MEK,or PI3K totally suppressed the P4-effect.Finally,the P4-enhanced survival of newborn neurons was accompanied by a potentiation of spatial learning and memory,which was P4R-dependent.These findings suggest that P4 enhances the survival of newborn neurons through P4R and /or the Src-ERK and PI3K pathways independent of its influence on cell proliferation,which is well correlated with the potentiated spatial cognitive function of P4-treated animals. | Sokabe Masahiro | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 5 |
| 3 | DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats显示文摘 | Li, Z. Cui, S. Z. Zhang, Z. Zhou, R. Ge, Y. B. Sokabe, M. Chen, L. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 4 |
| 4 | Strech-activated ion channels and membrane mechanics显示文摘 | Sachs F Sokabe M | 1990 | Neurosci Res1990，12，： | 1 |
| 5 | Effects of tensile and com?pressive strains on response of a chondrocytic cell line embedded in type I collagen gel显示文摘 | Hirano Y Ishiguro N Sokabe M | 2008 | J Biotechnol2008，133，2： | 1 |
| 6 | Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions 显示文摘 | Kobayashi T Sokabe M | 2010 | Curr Opin Cell Biol2010，22，5： | 1 |
| 7 | Actin stress fiberstransmit and focus force to activate mechanosensitive chan-nels 显示文摘 | Hayakawa K Tatsumi H Sokabe M | 2008 | J Cell Sci2008，121，4： | 1 |
| 8 | Evaluation of extensional and torsional stiffness of single actin filaments by molecular dynamics analysis 显示文摘 | Matsushita S Adachi T Inoue Y Hojo M Sokabe M | 2010 | Journal of Biomechan- ics2010，43，16： | 1 |
| 9 | Chronic administration of DHEAS primes for facilitation induction of long-term po- tentiation via sigma 1 receptor:optical imaging study in rat hippocampal slices显示文摘 | Chen L Dai X Sokabe M | 2006 | Neuropharmacology2006，50，3： | 1 |
| 10 | Effect of tensile force on the mechani- cal behavior of actin filaments显示文摘 | Matsushita S Inoue Y Hojo M Sokabe M Adachi T | 2011 | Journal ofBiomechanics2011，44，9： | 1 |
| 11 | Zyxin emerges as a key player in the mechanotransduction at cell adhesive structures显示文摘 | Hirata H Tatsumi H Sokabe M | 2008 | Communicative & Integrative Biology2008，2，1： | 1 |
| 12 | Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro显示文摘 | Yamamoto K Sokabe T Watabe T | 2005 | Am J Physiol Heart Circ Physiol2005，288，4： | 1 |
| 13 | Structural changes in the cytoplasmic domain of the mechanosensitive channel mscs during opening 显示文摘 | Machiyama H Tatsumi H Sokabe M | 2009 | Biophys J2009，97，4： | 1 |
| 14 | Loss-of-function mutations at the rim of the funnel of mechanosensilive channel MscL 显示文摘 | Yoshimura K Nomura T Sokabe M | 2004 | Biophys J2004，86，4： | 1 |
| 15 | Does so-called streptozocin hypertension exist in rats? 显示文摘 | Kusaka M Kishi K Sokabe H | 1987 | Hypertension1987，10，5： | 1 |
| 16 | Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice显示文摘 | Yamamoto K Sokabe T Matsumoto T Yoshimura K Shibata M Ohura N | 2006 | Nat Med2006，12，1： | 1 |
| 17 | Molecular design and synthesis of artificial ion channels based on cyclic peptldes containing unnatural amino acids 显示文摘 | ISHIDA H QI Z SOKABE M | 2001 | J Org Chem2001，66，9： | 1 |
| 18 | Kanamycin induced low-frequency hearing loss in the budgerigar显示文摘 | Hashino E Sokabe M | 1989 | Acoust Soc Am1989，85，： | 1 |
| 19 | Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro显示文摘 | YAMAMOTO K SOKABE T WATABE T | 2005 | American Journal of Physiology-Heart and Circulatory Physiology2005，288，4： | 1 |
| 20 | Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells显示文摘 | SOKABE T YAMAMOTO K OHURA N | 2004 | Am J Physiol Heart Circ Physiol2004，287，5： | 1 |
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